Results 81 to 90 of about 326,550 (210)

β2-Adrenergic Receptor Agonists in Diabetic Kidney Disease: Exploring a New Frontier

Biochemistry Research International
Diabetic kidney disease is a major cause of end-stage kidney disease. Various metabolic, hemodynamic, inflammatory, and profibrotic factors secondary to diabetes mellitus result in complex intracellular signaling, which in turn is responsible for the ...
Shreya Hegde, Bharti Chogtu, Rahul Magazine, Ravindra Prabhu   +3 more
doaj   +1 more source

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Nature Communications, 2019
Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate
Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, Naoto Suzuki, Koki Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, Kei Asaji, Chikahisa Mukawa, Hiroki Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, Tomoyuki Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N. Fukuda, Hsin-Jung HO, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, Shizuko Nagao, Yusuke Ohsaki, Satoshi Shimada, Takehiro Suzuki, Takafumi Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, Mariko Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C. Breeggemann, Jurgen Heymann, Miho Shimizu, Susumu Ogawa, Nobuyuki Takahashi, Takashi Suzuki, Yuji Owada, Shigeo Kure, Nariyasu Mano, Tomoyoshi Soga, Takashi Wada, Jeffrey B. Kopp, Shinji Fukuda, Atsushi Hozawa, Masayuki Yamamoto, Sadayoshi Ito, Jun Wada, Yoshihisa Tomioka, Takaaki Abe   +55 more
doaj   +1 more source

Prevention of Protein Glycation by Natural Compounds [PDF]

, 2015
Non-enzymatic protein glycosylation (glycation) contributes to many diseases and aging of organisms. It can be expected that inhibition of glycation may prolong the lifespan.
Bartosz, Grzegorz, Sadowska-Bartosz, Izabela   +1 more
core   +2 more sources

Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship [PDF]

, 2018
Diabetic nephropathy (DN) is the most frequent cause of chronic renal failure. Until now, the pathophysiological mechanisms that determine its development and progression have not yet been elucidated.
Agüero, Rocio, Ezquer, Eduardo Marcelo, Ezquer, Fernando, Fader Kaiser, Claudio Marcelo, Giraud Billoud, Maximiliano German   +4 more
core  

The role of kidney biopsy in deciphering diabetic versus non-diabetic origin of kidney disease among patients with type 2 diabetes mellitus and nephrotic range proteinuria: A retrospective study

Metabolism Open
Background: Diabetes mellitus (DM) is tightly associated with the increased prevalence of diabetic kidney disease (DKD). Nonetheless, severe renal function impairment and/or nephrotic range-proteinuria could also result from non-diabetic renal disease ...
Efstratios Kardalas, Aggeliki Paikopoulou, Dimitra A. Vassiliadi, Dimitris Kounatidis, Natalia G. Vallianou, Christine Vourlakou, Irene Karampela, Maria Dalamaga, Marinella Tzanela, Theodora Stratigou   +9 more
doaj   +1 more source

Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease [PDF]

, 2000
Allan Flyvbjerg
openalex   +1 more source

Diabetic kidney disease research: Where do we stand at the turn of the century? [PDF]

, 2000
Hi Bahl Lee, Hunjoo Ha, Sung Il Kim, Fuad N. Ziyadeh   +3 more
openalex   +1 more source

The key mediator of diabetic kidney disease: Potassium channel dysfunction

Genes and Diseases
Diabetic kidney disease is a leading cause of end-stage renal disease, making it a global public health concern. The molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex pathogenesis.
Jia Guo, Chaojie Zhang, Hui Zhao, Yufan Yan, Zhangsuo Liu   +4 more
doaj   +1 more source

Orally active, species-independent novel A3 adenosine receptor antagonist protects against kidney injury in db/db mice

Experimental and Molecular Medicine, 2018
Diabetic kidney disease: drug successfully targets key protein A therapeutic treatment targeting a protein involved in the progression of diabetic kidney disease (DKD) shows promise in mouse trials.
Debra Dorotea, Ahreum Cho, Gayoung Lee, Guideock Kwon, Junghwa Lee, Pramod K. Sahu, Lak Shin Jeong, Dae Ryong Cha, Hunjoo Ha   +8 more
doaj   +1 more source

Simultaneous pancreas-kidney transplantation reduces excess mortality in type 1 diabetic patients with end-stage renal disease [PDF]

, 2000
Bryan N. Becker, Peter C. Brazy, Yolanda T. Becker, Jon S. Odorico, Thomas J. Pintar, Bradley H. Collins, J D Pirsch, Glen Leverson, Dennis M. Heisey, Hans W. Sollinger   +9 more
openalex   +1 more source