Results 131 to 140 of about 34,166 (308)

Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

open access: yesChemistryOpen, EarlyView.
Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Mohd Shahnawaz Khan   +3 more
wiley   +1 more source

The Renoprotective Effects of Sodium Valproate as a Histone Deacetylase Inhibitor on Diabetic Nephropathy

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017
BACKGROUND AND OBJECTIVE: Diabetic nephropathy (DN), as the most common cause of end-stage renal failure, caused by protein kinase C pathway and reactive oxygen species.
R Ataee, H Esmaeeli
doaj  

Fibroblast‐specific palladin drives kidney fibrosis via MRTF–SRF signaling

open access: yesThe Journal of Pathology, EarlyView.
Abstract Fibrosis is a common end‐stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin‐related transcription factor (MRTF)–serum response factor (SRF) signaling drives the expression of fibrosis‐related molecules through actin cytoskeleton dynamics in renal fibroblasts.
Naoki Yamamoto   +27 more
wiley   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov   +3 more
wiley   +1 more source

Diabetic Nephropathy [PDF]

open access: hybrid, 1990
Peter Watkins
openalex   +1 more source

Nrf2‐Mediated Ferroptosis Is Involved in Berberine‐Induced Alleviation of Diabetic Kidney Disease

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Diabetic kidney disease (DKD) is the most common and serious complication of diabetes mellitus. Currently, there is a lack of safe and effective preventive strategies for DKD. The study aimed to explore the preventive effects and potential mechanisms of berberine (BBR) against DKD.
Kun Gao   +6 more
wiley   +1 more source

Effect of Consumption of Honey Containing Bacillus coagulans on Inflammatory and Oxidative Stress Factors in Patients with Diabetic Nephropathy

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: Diabetic nephropathy is one of the dangerous complications of diabetes, which has a relatively high incidence in diabetic patients and causes kidney failure.
Navid Mazrouei Arani   +4 more
doaj  

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