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Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation

Journal of Biological Engineering, 2022
Diabetic nephropathy, a kidney complication arising from diabetes, is the leading cause of death in diabetic patients. Unabated, the growing epidemic of diabetes is increasing instances of diabetic nephropathy.
Haryana Y. Thomas, Ashlee N. Ford Versypt   +1 more
doaj   +2 more sources

Oxidative Stress Markers in Chronic Kidney Disease with Emphasis on Diabetic Nephropathy

Antioxidants, 2020
Diabetes prevalence is increasing worldwide, especially through the increase of type 2 diabetes. Diabetic nephropathy occurs in up to 40% of diabetic patients and is the leading cause of end-stage renal disease. Various factors affect the development and
Nina Vodošek Hojs, Sebastjan Bevc, Robert Ekart, Radovan Hojs   +3 more
doaj   +2 more sources

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.

PLoS ONE, 2018
To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs)
Makiko Taira, Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani, Toshimasa Yamauchi, Shin-Ichi Araki, Nobue Tanaka, Natalie R van Zuydam, Emma Ahlqvist, Masao Toyoda, Tomoya Umezono, Koichi Kawai, Masahito Imanishi, Hirotaka Watada, Daisuke Suzuki, Hiroshi Maegawa, Tetsuya Babazono, Kohei Kaku, Ryuzo Kawamori, SUMMIT Consortium, Leif C Groop, Mark I McCarthy, Takashi Kadowaki, Shiro Maeda   +23 more
doaj   +2 more sources

Platelet Indices as Predictors of Diabetic Kidney Disease in Type 2 Diabetes Mellitus [PDF]

International Journal of Medical Arts, 2023
Background: Type 2 diabetes (T2D) is characterized as a complicated and varied group of metabolic conditions. The disorder's defining feature is increased blood sugar level brought on by a malfunction in insulin action and/or secretion.Aim of the Work ...
Ahmed Elsayed, Mahmoud Bazeed, Youssef Nassar, Nesreen Hamdy   +3 more
doaj   +1 more source

Bidirectional association between depression and diabetic nephropathy by meta-analysis

PLoS ONE, 2022
Background Studies suggested that the association between depression and diabetic nephropathy may be bi-directional, but this hypothesis remains investigating.
Tingting Fang, Qiuling Zhang, Zhiguo Wang, Jun-Ping Liu   +3 more
doaj   +2 more sources

Urinary MicroRNA Profiling in the Nephropathy of Type 1 Diabetes [PDF]

, 2013
Background: Patients with Type 1 Diabetes (T1D) are particularly vulnerable to development of Diabetic nephropathy (DN) leading to End Stage Renal Disease.
A Krupa, A Micera, Analysis The Case for Objective Bayesian, AO Phillips, B John, Christos Argyropoulos, D Lunn, D Macconi, D Shan, David Galas, David Huang, Demetrius Ellis, DP Bartel, G Ghosh, G Togliatto, G Wang, G Wang, G Wang, H Guo, H Haller, H Sun, J Hou, JA Weber, JM Lorenzen, John Johnson, Jose Bernardo, K Bhatt, K Heese, K Sharma, Kai Wang, Karin Jandeleit-Dahm, L Denby, L Held, L Mahimainathan, L Matthews, M Ashburner, M Hackl, M Kato, M Kato, M Kato, ME Molitch, MW Pfaffl, O García-Sánchez, P Dentelli, P Kantharidis, P Ruggenenti, PE Pergola, R Bonofiglio, R Liao, RC Friedman, RC Gentleman, RC Lee, RW Carthew, S Fatima, Sara McClarty, SM Titan, SW Shan, T Roweis, Sam, TD Schmittgen, Trevor Orchard, U Tran, VA Valera, W Stacklies, X Wang, X-Y Bai, Y Dai, YS Kanwar, Z Chun-Zhi   +67 more
core   +12 more sources

Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols

Frontiers in Immunology, 2023
Diabetic nephropathy (DN) often leads to end-stage renal disease. Oxidative stress demonstrates a crucial act in the onset and progression of DN, which triggers various pathological processes while promoting the activation of inflammation and forming a ...
Qi Jin, Tongtong Liu, Yuan Qiao, Donghai Liu, Liping Yang, Hui-min Mao, Fang Ma, Yuyang Wang, Liang Peng, Yongli Zhan   +9 more
semanticscholar   +1 more source

Deciphering the role of short-chain fatty acids (SCFAs) in diabetic nephropathy: protective or pathogenic mediators? [PDF]

Ann Med Surg (Lond)
Yaseen K, Khalid M, Asif A, Amin MHJ.
europepmc   +2 more sources

Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice

Nature Communications, 2023
Statins play an important role in the treatment of diabetic nephropathy. Increasing attention has been given to the relationship between statins and insulin resistance, but many randomized controlled trials confirm that the therapeutic effects of statins
Tong-sheng Huang, Teng Wu, Yandi Wu, Xinghui Li, Jing Tan, Cong-hui Shen, Shiquin Xiong, Zi-qi Feng, Sai-fei Gao, Hui Li, W. Cai   +10 more
semanticscholar   +1 more source

Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment

BioMed Research International, 2021
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Chronic hyperglycemia and high blood pressure are the main risk factors for the development of DN.
Nur Samsu
semanticscholar   +1 more source