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Rodent models of diabetic nephropathy: their utility and limitations
Munehiro Kitada,1,2 Yoshio Ogura,2 Daisuke Koya1,2 1Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, 2Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, Japan Abstract:
Kitada M, Ogura Y, Koya D
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Background and objective: Diabetes is the most common cause of chronic renal disease globally. Diabetic nephropathy (DN) is one of the most serious consequences of type 2 diabetes.
Asaad Al-Khafaji +4 more
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Current therapeutic management of diabetic nephropathy [PDF]
Roughly 40% of all patients with insulin-dependent diabetes mellitus (IDDM) develop diabetic nephropathy with proteinuria, hypertension and a decrease in glomerular filtration rate 10 to 20 years after the onset of the disease, and 5 years later most ...
Kohler, S. M., Krämer, Bernhard K.
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Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus [PDF]
BACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality.
Bell Christopher G +30 more
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MicroRNAs in Podocyte Injury in Diabetic Nephropathy
Diabetic nephropathy is one of the major complications of diabetes mellitus and is the leading cause of end-stage renal disease worldwide. Podocyte injury contributes to the development of diabetic nephropathy.
Hiroki Ishii +7 more
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The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]
The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
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CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]
Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Amann, Kerstin Ute +11 more
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MicroRNA and Microvascular Complications of Diabetes
In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have
F. Barutta +4 more
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Perspectives on the News commentaries are part of a free monthly CME activity. The Mount Sinai School of Medicine, New York, New York, designates this activity for 2.0 AMA PRA Category 1 credits. If you wish to participate, review this article and visit www.diabetes.procampus.net to complete a posttest and receive a certificate.
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