Baseline characteristics and enrichment results from the SONAR trial [PDF]
, 2018 Aim: The SONAR trial uses an enrichment design based on the individual response to the selective endothelin receptor antagonist atrasentan on efficacy (the degree of the individual response in the urinary albumin‐to‐creatinine ratio [UACR]) and safety/
Andress, Dennis L. +15 more
core +3 more sources
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
core +1 more source
Disease-a-Month, 1998 Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD) and accounts for 35% of the ESRD population in the United States. It results in considerable morbidity, mortality, and expense. The average cost of managing one diabetic patient with ESRD is approximately $50,000 a year.
openaire +3 more sources
Journal of Biological Engineering, 2022 Diabetic nephropathy, a kidney complication arising from diabetes, is the leading cause of death in diabetic patients. Unabated, the growing epidemic of diabetes is increasing instances of diabetic nephropathy.
Haryana Y. Thomas +1 more
doaj +1 more source
Visfatin reduces gap junction mediated cell-to-cell communication in proximal tubule-derived epithelial cells [PDF]
, 2013 Background/Aims: In the current study we examined if the adipocytokine, visfatin, alters connexin-mediated intercellular communication in proximal tubule-derived epithelial cells.
Hills, Claire E. +3 more
core +2 more sources
The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy
Journal of Diabetes Research, 2013 Diabetic nephropathy is a leading cause of end-stage renal disease worldwide. The multipronged drug approach targeting blood pressure and serum levels of glucose, insulin, and lipids fails to fully prevent the onset and progression of diabetic ...
Kosuke Yamahara +5 more
doaj +1 more source
Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. [PDF]
, 2015 Apolipoprotein L1 gene (APOL1) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans (AAs). Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin ...
Bild, Diane E +14 more
core +1 more source
Recent Advances of Metformin in Treatment of Diabetic Nephropathy [PDF]
Zhongguo quanke yixueDiabetic nephropathy is one of the most common complications of diabetic microangiopathy, which significantly reduces the quality of life of diabetic patients and is the main cause of end-stage renal failure.
DENG Yuxuan, HUANG Xuejun, JIANG Yanxia
doaj +1 more source
Kidney Injury Molecule-1 (Kim-1) sebagai Biomarker Dini Nefropati Diabetik pada Pasien Diabetes Melitus Tipe 2 [PDF]
, 2017 Diabetic nephropathy is a chronic complication of type 2 diabetes mellitus (DM). To prevent the onset or progression of nephropathy, a biomarker is needed that can detect kidney problems at an early stage.
Tangkelangi, M. (Marni)
core +1 more source
Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]
, 2011 Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
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