Results 51 to 60 of about 432,036 (307)

Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes [PDF]

, 2012
Increased renal clearance of thiamine (vitamin B1) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy.
Larkin James R., Guerman Molostvov, Fang Zhang, Naila Rabbani, Thornalley, Paul J., Zhang Fang, Zhang, F. (Fang), Rabbani, Naila, Godfrey Lisa, Molostvov Guerman, James R Larkin, Zehnder Daniel, Paul J. Thornalley, Lisa Godfrey, Zehnder, Daniel, Daniel Zehnder, Godfrey, L. (Lisa), Rabbani Naila, Larkin, James Robert, Thornalley Paul J., Paul J Thornalley, James R. Larkin, Molostvov, Guerman   +22 more
core   +2 more sources

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Effects of physical activity on the development and progression of microvascular complications in type 1 diabetes : retrospective analysis of the DCCT study [PDF]

, 2013
Background: To examine the effects of physical activity on the development and progression of microvascular complications in patients with type 1 diabetes. Methods: A retrospective analysis of data from the Diabetes Control and Complications trial was
Krishnarajah Nirantharakumar, Saravanan, Ponnusamy, Narendran, Parth, Caroline BT Makura, Nirantharakumar, Krishnarajah, Narendran, Partheepan; id_orcid, Parth Narendran, Girling, Alan J, Ponnusamy Saravanan, Makura, Caroline BT, Alan J Girling   +10 more
core   +2 more sources

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

The Clinical Value of Serum Adropin Level in Early Detection of Diabetic Nephropathy

Kidney & Blood Pressure Research, 2021
Background/Aims: Adropin is a metabolic hormone secreted by the liver, brain, and many peripheral tissues and is involved in energy homeostasis and insulin sensitivity.
Ali Es-haghi, Tuqa Al-Abyadh, Hassan Mehrad-Majd   +2 more
doaj   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Recent Progress in Genetics and Epigenetics Research on Diabetic Nephropathy in Malaysia

Journal of Diabetes Research, 2023
Diabetic nephropathy is a multifactorial disease. Gene susceptibility, as well as environmental exposure, plays an important role in disease progression.
Norhashimah Abu Seman, Siti Haslina Othman   +1 more
doaj   +1 more source

Diabetic alteration versus postnatal maturation of rat kidney glycoconjugates — comparative detection by lectin probes [PDF]

, 2013
A panel of ten lectins with different carbohydrate specificities, including three original lectin preparations (MPFA, LABA, and LVA), was used for the investigation of rat kidney glycoconjugate remodeling during postnatal morphogenesis, and the findings ...
Ambarova, Natalya; Department of Histology and Embryology, Lviv National, Medical University, Lviv, Ukraine, Lutsyk, Alexander; Department of Histology and Embryology, Lviv National, Medical University, Lviv, Ukraine, Antonyuk, Volodymyr; Department of Histology and Embryology, Lviv National, Medical University, Lviv, Ukraine; Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine   +2 more
core   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source