Results 11 to 20 of about 845,031 (279)

Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation

open access: yesJournal of Biological Engineering, 2022
Diabetic nephropathy, a kidney complication arising from diabetes, is the leading cause of death in diabetic patients. Unabated, the growing epidemic of diabetes is increasing instances of diabetic nephropathy.
Haryana Y. Thomas   +1 more
doaj   +2 more sources

Oxidative Stress Markers in Chronic Kidney Disease with Emphasis on Diabetic Nephropathy

open access: yesAntioxidants, 2020
Diabetes prevalence is increasing worldwide, especially through the increase of type 2 diabetes. Diabetic nephropathy occurs in up to 40% of diabetic patients and is the leading cause of end-stage renal disease. Various factors affect the development and
Nina Vodošek Hojs   +3 more
doaj   +2 more sources

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.

open access: yesPLoS ONE, 2018
To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs)
Makiko Taira   +23 more
doaj   +2 more sources

Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols

open access: yesFrontiers in Immunology, 2023
Diabetic nephropathy (DN) often leads to end-stage renal disease. Oxidative stress demonstrates a crucial act in the onset and progression of DN, which triggers various pathological processes while promoting the activation of inflammation and forming a ...
Qi Jin   +9 more
semanticscholar   +1 more source

Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice

open access: yesNature Communications, 2023
Statins play an important role in the treatment of diabetic nephropathy. Increasing attention has been given to the relationship between statins and insulin resistance, but many randomized controlled trials confirm that the therapeutic effects of statins
Tong-sheng Huang   +10 more
semanticscholar   +1 more source

Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment

open access: yesBioMed Research International, 2021
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Chronic hyperglycemia and high blood pressure are the main risk factors for the development of DN.
Nur Samsu
semanticscholar   +1 more source

Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy

open access: yesFrontiers in Endocrinology, 2022
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes. Microvascular endothelial cells are thought to be the major targets of hyperglycemic injury.
Jing Yang, Zhangsuo Liu
semanticscholar   +1 more source

Up-Date on Diabetic Nephropathy

open access: yesLife, 2022
Diabetes is one of the leading causes of kidney disease. Diabetic kidney disease (DKD) is a major cause of end-stage kidney disease (ESKD) worldwide, and it is linked to an increase in cardiovascular (CV) risk.
M. Pelle   +6 more
semanticscholar   +1 more source

Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis

open access: yesMedical Science Monitor, 2022
Diabetic nephropathy is a common complication of type I and type II diabetes, in which renal glomeruli are destroyed, resulting in renal damage, proteinuria, and hypertension.
N. Erekat
semanticscholar   +1 more source

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