Results 101 to 110 of about 150,695 (362)

Role of inflammatory biomarkers in diabetic peripheral neuropathy

Journal of Diabetes Investigation, 2018
Inflammatory pathway from hyperglycemia to diabetic peripheral neuropathy is very important in diagnosis and management. Inflammatory cytokine can be used for prediction and progression of diabetic peripheral neuropathy.
H. Jin, T. Park
semanticscholar   +1 more source

Metabolomic signature of type 1 diabetes-induced sensory loss and nerve damage in diabetic neuropathy [PDF]

arXiv, 2018
Diabetic-induced peripheral neuropathy (DPN) is a diabetic late complication. The molecular mechanisms underlying the pathophysiology of nerve damage & sensory loss remain largely unclear. Recently, alterations in metabolic flux have gained attention a basis for organ damage in diabetes; however, peripheral sensory neurons have not been adequately ...
arxiv  

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Role of Inflammation in the Pathogenesis of Diabetic Peripheral Neuropathy

Open Access Macedonian Journal of Medical Sciences, 2019
BACKGROUND: Diabetic peripheral neuropathy (DPN) means the presence of symptoms and/or signs of peripheral nerve damage that occur to people with diabetes, excluding all other causes of neuropathy.
Daniela Ristikj-Stomnaroska, Valentina Risteska-Nejashmikj, M. Papazova   +2 more
semanticscholar   +1 more source

Differential action of TIGIT on islet and peripheral nerve autoimmunity in the NOD mouse [PDF]

arXiv, 2023
We previously demonstrated that the abrogation of the ICOS pathway prevents type 1 diabetes development in the Non Obese Diabetic (NOD) mouse, but results in a CD4+ T-cell dependent autoimmune neuromyopathy in aged mice. Pancreatic islet infiltrates in conventional NOD mice and neuromuscular infiltrates in Icosl-/- NOD mice have in common that they ...
arxiv  

Delays in diagnosis and treatment of ATTR cardiac amyloidosis: A real‐world data analysis

ESC Heart Failure, EarlyView.
Abstract Aims and Background Cardiac amyloidosis leads to functional cardiac impairment and heart failure. Transthyretin amyloid cardiomyopathy (ATTR‐CM) is the most common form. After initial suspicion, diagnosis involves imaging techniques, biopsy and genetic tests, prompting transthyretin stabilizer therapy to slow disease progression.
Julia Vogel, Sophia Jura, Stephan Settelmeier, Florian Buehning, Tobias Lerchner, Alexander Carpinteiro, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

CLINICODIAGNOSTIC SIGNIFICANCE OF CILIARY AND BRAIN-DERIVED NEUROTROPHIC FACTORS IN CHILDREN WITH DIABETIC PERIPHERAL NEUROPATHY

Медицинский вестник Юга России, 2013
Purpose: To investigate the role of ciliary and brain-derived neurotrophic factors in the development of diabetic peripheral neuropathy in children and teenagers with type-1 diabetes (T1D).Materials and methods: The article contains check-up results of ...
A. A. Afonin, G. A. Galkina, M. V. Komkova, N. V. Morozova   +3 more
doaj   +1 more source

Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study

Diabetes Care, 2017
OBJECTIVE We assessed the prevalence of and risk factors for diabetic peripheral neuropathy (DPN) in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) enrolled in the SEARCH for Diabetes in Youth (SEARCH) study.
M. Jaiswal, J. Divers, D. Dabelea, S. Isom, R. Bell, Catherine L. Martin, D. Pettitt, S. Saydah, C. Pihoker, D. Standiford, L. Dolan, S. Marcovina, B. Linder, A. Liese, R. Pop-Busui, E. Feldman   +15 more
semanticscholar   +1 more source

Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type 2 Diabetic Mice

Diabetes, 2020
Schwann cell–derived exosomes communicate with dorsal root ganglia (DRG) neurons. The current study investigated the therapeutic effect of exosomes derived from healthy Schwann cells (SC-Exos) on diabetic peripheral neuropathy (DPN).
Lei Wang, M. Chopp, A. Szalad, Xuerong Lu, Yi Zhang, Xinli Wang, P. Cepparulo, Mei Lu, Chao Li, Zhenggang Zhang   +9 more
semanticscholar   +1 more source