Results 51 to 60 of about 468,347 (281)

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Grading diabetic retinopathy (DR) using the Scottish grading protocol

Community Eye Health Journal, 2016
Although traditionally the features of DR have been identified through direct ophthalmoscopy or slit lamp biomicroscopy, digital photography is more sensitive than direct ophthalmoscopy and is comparable to slit lamp examination by a trained observer.
Sonia Zachariah , William Wykes , David Yorston   +2 more
doaj  

Demographics, Awareness and Pattern of Diabetic Retinopathy among Diabetic Patients

Journal of Nobel Medical College
Background: Diabetic retinopathy is one of the emerging causes of blindness in developing countries. This study was carried out among diabetic patients to determine the demographics, severity of diabetic retinopathy and also to assess the level of ...
Anjila Basnet, Raghunandan Byanju, Samir Thapa, Sanjit Kumar Shah, Suman Simkhada   +4 more
doaj   +1 more source

Pharmacological mydriasis in patients with type 2 diabetes. A comparative study among different levels of diabetic retinopathy [PDF]

Revista Brasileira de Oftalmologia
Objective: To analyze the diabetic autonomic neuropathy through the comparison between the pharmacological mydriasis in patients without diabetes and with type 2 diabetes. Methods: This is an observational, cross-sectional, case-control study.
Felipe Bekman Rocha, Nadyr Antonia Damasceno, Luziane Herzog de Azeredo Ramalho, Adroaldo de Alencar Costa Filho, Marcio Penha Morterá Rodrigues, Maria Luiza Gois da Fonseca, Raphael Boechat, Rubens Antunes da Cruz Filho, Eduardo de França Damasceno   +8 more
doaj   +1 more source

Injectable Peptide‐Based Functional Amyloid Hydrogels as Tunable Depots for Sustained Drug Delivery

Advanced Science, EarlyView.
An injectable and tunable peptide‐based functional amyloid hydrogel provides sustained insulin release while preserving insulin stability and bioactivity. The hydrogel enables prolonged glycemic regulation in vivo, exhibits excellent biocompatibility, and shows no detectable IAPP and α‐Syn heterologous cross‐seeding, highlighting its potential as a ...
Ranjit Shaw, Niyamat M. A. Chimthanawala, Shouvik Manna, Sadhana Sathaye, Samir K. Maji   +4 more
wiley   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Cost–benefit analysis of screening programme for diabetic retinopathy in Bulgaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Late‐diagnosed diabetic retinopathy (DR) is difficult and expensive to treat. Screening programmes can identify the disease early and reduce the costs of its future treatment. This study aims to analyse the cost–benefit of screening programmes for DR.
Iva Nenkova, Yoana Lilova, Alexander Oscar, Alina Levi, Maria Kamusheva, Guenka Petrova   +5 more
wiley   +1 more source

Systemic Diseases and the Eye: A Translational Perspective on Diabetes

Chronic Diseases and Translational Medicine, EarlyView.
The eye–brain–cardiometabolic axis in diabetes: retinal biomarkers as indicators of systemic disease. ABSTRACT Diabetes mellitus is a global chronic disease that affects the whole body and not just glucose metabolism. In diabetes, non‐invasive ocular changes can help understand microvascular, neurodegenerative, and inflammatory processes. This analysis
Matteo Capobianco, Marco Zeppieri, Simonetta Gaia Nicolosi, Niccolò Castellino, Francesco Cappellani, Irene Gattazzo, Caterina Gagliano   +6 more
wiley   +1 more source