Results 101 to 110 of about 128,436 (385)

Comprehensive Genetic Map of Muscle Lipidome Reveals Novel Insights Into Flavor Variation in Ruminant Meat

open access: yesAdvanced Science, EarlyView.
Ruminant meat is widely appreciated for its distinctive flavor. Lipids play a central role in influencing meat flavor, yet their genetic and biochemical basis remains largely unexplored. Here, a comprehensive lipid genetic map of sheep muscle is constructed and 20 candidate genes potentially modulating lipid levels are identified to provide a roadmap ...
Xueying Zhang   +17 more
wiley   +1 more source

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. [PDF]

open access: yes, 2011
Clonal deletion of autoreactive B cells is crucial for the prevention of autoimmunity, but the signaling mechanisms that regulate this checkpoint remain undefined. Here we characterize a previously unrecognized Ca(2+)-driven pathway for activation of the
Depeille, Philippe   +7 more
core  

Improvement of Neutral Lipid and Polyunsaturated Fatty Acid Biosynthesis by Overexpressing a Type 2 Diacylglycerol Acyltransferase in Marine Diatom Phaeodactylum tricornutum

open access: yesMarine Drugs, 2013
Microalgae have been emerging as an important source for the production of bioactive compounds. Marine diatoms can store high amounts of lipid and grow quite quickly.
Y. Niu   +6 more
semanticscholar   +1 more source

A role for diacylglycerol in antibacterial autophagy [PDF]

open access: yesAutophagy, 2011
Antibacterial autophagy is understood to be a key cellular immune response to invading microbes. However, the mechanism(s) by which bacteria are selected as targets of autophagy remain unclear. We recently identified diacylglycerol as a novel signaling molecule that targets bacteria to the autophagy pathway, and show that it acts via protein kinase C ...
John H. Brumell   +3 more
openaire   +3 more sources

Xylose Metabolism Perturbation in Yarrowia lipolytica for Efficient Succinic Acid Bioproduction from Lignocellulosic Biomass

open access: yesAdvanced Science, EarlyView.
This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong   +7 more
wiley   +1 more source

How to switch a master switch

open access: yeseLife, 2013
The crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras.
Christopher Hein   +2 more
doaj   +1 more source

Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans

open access: yesAging Cell, 2014
Target of rapamycin (TOR) signaling is a nutrient‐sensing pathway controlling metabolism and lifespan. Although TOR signaling can be activated by a metabolite of diacylglycerol (DAG), phosphatidic acid (PA), the precise genetic mechanism through which ...
Yen-Hung Lin   +14 more
semanticscholar   +1 more source

The biology and biochemistry of diacylglycerol signalling [PDF]

open access: yesEMBO reports, 2005
A few bottles of Rioja and some late‐evening dinners in the beautiful city of Madrid provided the setting for a workshop on Molecular Advances in Diacylglycerol Signalling. The participants were greeted by the impressive surroundings of the Juan March Institute with a concurrent exhibition of nineteenth‐century French paintings on the human body.
openaire   +3 more sources

A molecular mechanism for diacylglycerol-mediated promotion of negative caloric balance

open access: yesDiabetes, Metabolic Syndrome and Obesity, 2009
Hidekatsu Yanai1,2, Yoshiharu Tomono3, Kumie Ito1,2, Yuji Hirowatari4, Hiroshi Yoshida1,5, Norio Tada1,21Department of Internal Medicine, 2Institute of Clinical Medicine and Research, 3Department of Nutrition, 5Department of Laboratory Medicine, Jikei ...
Yanai H
doaj  

Diacylglycerols in the evaluation of virgin olive oil quality

open access: yesGrasas y Aceites, 1994
Virgin olive oil samples were analyzed within one month after extraction and after one year; edible and lampante olive oil samples were analyzed before and after neutralization of free acids.
M. Catalano, T. De Leonardis, S. Comes
doaj   +1 more source

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