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Inhibition of diacylglycerol kinases as a physiological way to promote diacylglycerol signaling
Advances in Biological Regulation, 2014Diacylglycerol is a key regulator of cell physiology, controlling the membrane recruitment and activation of signaling molecules. Accordingly, diacylglycerol generation and metabolism are strictly controlled, allowing for localized regulation of its concentration.
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Properties and functions of diacylglycerol kinases
Cellular Signalling, 2000Diacylglycerol kinases (DGKs) phosphorylate the second-messenger diacylglycerol (DAG) to phosphatidic acid (PA). The family of DGKs is well conserved among most species. Nine mammalian isotypes have been identified, and are classified into five subgroups based on their primary structure.
W J, van Blitterswijk, B, Houssa
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1996
Abstract Diacylglycerol kinase (DGK) reverses the normal flow of phospholipid biosynthesis by phosphory/ating diacylglycerol back to phosphatidic acid. DGK consists of a number of isozymes with different enzymological properties. The three isozymes so far sequenced, however, share highly conserved regions including two sets each of EF-
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Abstract Diacylglycerol kinase (DGK) reverses the normal flow of phospholipid biosynthesis by phosphory/ating diacylglycerol back to phosphatidic acid. DGK consists of a number of isozymes with different enzymological properties. The three isozymes so far sequenced, however, share highly conserved regions including two sets each of EF-
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Regulation of ‘signalling diacylglycerol’ in cells: the importance of diacylglycerol kinase
Biochemical Society Transactions, 1996M N, Hodgkin +3 more
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Measurement of Diacylglycerol: Origins of Receptor-Stimulated Diacylglycerol Accumulation
2003M R, Boarder, J R, Purkiss
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The International Journal of Biochemistry & Cell Biology, 1997
Fumio Sakane, Hideo Kanoh
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Fumio Sakane, Hideo Kanoh
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