Results 121 to 130 of about 73,981 (291)

SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling

, 2011
Diacylglycerol kinases (DGKs) metabolize diacylglycerol to phosphatidic acid. In T lymphocytes, DGKα acts as a negative regulator of TCR signaling by decreasing diacylglycerol levels and inducing anergy.
Bettio, V, Chianale, F., Baldari, Cosima T., Zhong, X. P., van Blitterswijk, Wim J., Patrussi L, Parolini, Ornella, Zhong, Xiao-Ping, Kim E. Nichols, Bettio V, Baldanzi, G., Nichols KE, Baldari, Cosima, Traini S, Andrea Pighini, Patrussi, Laura, Wim J. van Blitterswijk, Mesturini R, Schweighoffer, Tamas, Zhong XP, Bettio, Valentina, Ornella Parolini, Pighini, Andrea, Graziani, Andrea, Song, S., Fabiola Sinigaglia, Porporato PE, Mesturini, R., Sinigaglia, F., Nicoletta Filigheddu, Andrea Graziani, Bettio, V., Nichols, K. E., Parolini, O., Sara Traini, Chianale, Federica, Paolo E. Porporato, Xiao-Ping Zhong, Ignacio Rubio, Nichols, Kim E., Rubio, Ignacio, van Blitterswijk WJ, Filigheddu, Nicoletta, Zhong, Xiao Ping, Schweighoffer T, Rubio I, Gianluca Baldanzi, Traini, S., Schweighoffer, T., Pighini A, Baldari CT, Porporato, Paolo E., Porporato, Paolo, Rainero, Elena, Rainero, E., Elena Rainero, van Blitterswijk W. J., Traini, Sara, Song SP, Graziani A., Laura Patrussi, Tamas Schweighoffer, Baldanzi, Gianluca, Rubio, I., Filigheddu, N., Graziani, A., Pighini, A., Rainero, E, Chianale F, Porporato, P. E., Parolini O, Valentina Bettio, Rainero E, Song, Shuping, Mesturini, Riccardo, Riccardo Mesturini, Shuping Song, Cosima T. Baldari, Sinigaglia, Fabiola, Federica Chianale   +79 more
core   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networks. [PDF]

, 2007
There exists an active lipid metabolism in the nucleus, which is regulated differentially from the lipid metabolism taking place elsewhere in the cell. Evidence has been accumulated that nuclear lipid metabolism is closely involved in a variety of cell ...
Martelli AM, Evangelisti C, Tabellini G, Goto K, Falà F, Bortul R   +5 more
core   +1 more source

Negative regulation of diacylglycerol kinase mediates adenosine-dependent hepatocyte preconditioning

, 2010
In liver ischemic preconditioning (IP), stimulation of adenosine A2a receptors (A2aR) prevents ischemia/reperfusion injury by promoting diacylglycerol-mediated activation of protein kinase C (PKC).
Carini R., Baldanzi G., Gaggianesi M., Graziani A., Dal Ponte C., DOMENICOTTI, CINZIA MARIA, Alchera E., Domenicotti C., Van Blitterswijk W. J., Imarisio C., NITTI, MARIAPAOLA, Albano E., Nitti M.   +12 more
core   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Method of modifying physical properties of palm-based diacylglycerol oil

, 2013
The present invention discloses a method to modify the physical properties of palm-based diacylglycerol oil. Accordingly, the method, which provides a palm-based diacylglycerol oil composition having improved physical properties of pourability, flow ...
Linm, Hong Kwong, Ng, Siou Pei, Tan, Chin Ping, Lai, Oi Ming   +3 more
core   +1 more source

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine

Small, EarlyView.
Hypotonic lysis in bidistilled water is used to remodel B lymphocyte–derived extracellular vesicles into cargo‐depleted, structurally preserved nanovesicles. The process reduces intraluminal proteins and nucleic acids, reshapes membrane composition, and enhances tumor‐cell uptake in vitro, while allowing proof‐of‐concept reloading with exogenous agents,
Francesca Susa, Lorenzo Arnaboldi, Veronica De Giorgis, Marco Ghirimoldi, Elettra Barberis, Marco Brucale, Francesco Valle, Mario Malerba, Marta Vallino, Angelo Musicò, Roberto Frigerio, Alessandro Gori, Vera Mugoni, Claudia Voena, Roberto Pisano, Fabrizio Pirri, Silvia Arpicco, Marcello Manfredi, Tania Limongi   +18 more
wiley   +1 more source