Diacylglycerol kinase η colocalizes and interacts with apoptosis signal-regulating kinase 3 in response to osmotic shock [PDF]
Biochemistry and Biophysics Reports, 2021 Diacylglycerol kinase (DGK) η translocates from the cytoplasm to punctate vehicles via osmotic shock. Apoptosis signal-regulating kinase (ASK) 3 (MAP kinase kinase kinase (MAPKKK) 15) is also reported to respond to osmotic shock.
Yuji Suzuki +3 more
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Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol [PDF]
FEBS Letters, 2015 Diacylglycerol kinase (DGK) η plays important roles in various patho-physiological events such as oncogenesis. In this study, we performed an enzymological characterization of DGKη splice variant 1 (DGKη1).
Hiromichi Sakai, Fumio Sakane
exaly +4 more sources
Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness [PDF]
Frontiers in Immunology, 2021 The diacylglycerol kinases (DGKs) are a family of enzymes responsible for the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). In addition to their primary function in lipid metabolism, DGKs have recently been identified as potential ...
Laryssa C. Manigat +7 more
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Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration [PDF]
Scientific ReportsDiacylglycerol kinases (DGKs) phosphorylate diacylglycerol to generate phosphatidic acid, which plays important roles in intracellular signal transduction. DGKα is reportedly associated with progression of tumors, including hepatocellular carcinomas, but
Hiroki Nakamoto +5 more
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Structure of membrane diacylglycerol kinase in lipid bilayers [PDF]
Communications Biology, 2021 Jianping Li et al. present the homo-trimeric structure of the small integral membrane protein diacylglycerol kinase (DgkA) in phospholipid bilayers determined by magic angle spinning solid-state NMR spectroscopy.
Jianping Li +9 more
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A dual diacylglycerol kinase (DGK) alpha/zeta inhibitor augments the activity of human tumor infiltrating lymphocytes in in vivo and ex vivo models [PDF]
OncoImmunologyEndogenous or adoptively transferred tumor-infiltrating lymphocytes (TILs) often lose their functional capacity due to the activation of intrinsic inhibitory pathways, which then limits their ability to control tumor growth.
Phurin Areesawangkit +20 more
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Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3 [PDF]
Thoracic Cancer, 2023 Background Diacylglycerol kinase α (DGKA) is the first member discovered from the diacylglycerol kinase family, and it has been linked to the progression of various types of tumors. However, it is unclear whether DGKA is linked to the development of lung
Dong Zhou +9 more
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Phosphorylation of pig brain diacylglycerol kinase by endogenous protein kinase
FEBS Letters, 1986 Pig brain diacylglycerol kinase did not catalyze autophosphorylation. However, the kinase was phosphorylated on serine, when immunoprecipitated from the partially purified enzyme preparation preincubated with Mg2+ and [γ-32P]ATP.
Hideo Kanoh
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Diacylglycerol Kinase alpha in X Linked Lymphoproliferative Disease Type 1 [PDF]
Int J Mol Sci, 2021 Diacylglycerol kinases are intracellular enzymes that control the balance between the secondary messengers diacylglycerol and phosphatidic acid. DGKα and DGKζ are the prominent isoforms that restrain the intensity of T cell receptor signalling by ...
Sara Centonze +7 more
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Diacylglycerol directly stimulates the insulin receptor tyrosine kinase
FEBS Letters, 1996 Studies with detergent: lipid mixed micelles reveal that diacylglycerol directly stimulates the intrinsic tyrosine kinase activity of the insulin receptor. Kinetic analyses indicate that diacylglycerol activates the kinase by causing a marked increase in
Rebecca S Arnold, Alexandra C Newton
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