Results 1 to 10 of about 441 (94)
Prokaryotic Diacylglycerol Kinase and Undecaprenol Kinase [PDF]
Annual Review of Biophysics, 2012 Prokaryotic diacylglycerol kinase (DAGK) and undecaprenol kinase (UDPK) are the lone members of a family of multispan membrane enzymes that are very small, lack relationships to any other family of proteins—including water soluble kinases—and exhibit an unusual structure and active site architecture.
Wade D, Van Horn, Charles R, Sanders
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Diacylglycerol Kinases in Signal Transduction
International Journal of Molecular Sciences, 2022 In recent years, the significant research efforts put into the clarification of the PI3K/AKT/mTOR pathway resulted in the approval of the first targeted therapies based on lipid kinase inhibitors [...]
Sara Centonze, Gianluca Baldanzi
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Diacylglycerol kinases in membrane trafficking [PDF]
Cellular Logistics, 2015 Diacylglycerol kinases (DGKs) belong to a family of cytosolic kinases that regulate the phosphorylation of diacylglycerol (DAG), converting it into phosphatidic acid (PA). There are 10 known mammalian DGK isoforms, each with a different tissue distribution and substrate specificity.
Shuwei, Xie +2 more
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Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol [PDF]
FEBS Letters, 2015 Diacylglycerol kinase (DGK) η plays important roles in various patho‐physiological events such as oncogenesis. In this study, we performed an enzymological characterization of DGKη splice variant 1 (DGKη1). The K m value for diacylglycerol was 0.14 mol%.
Komenoi, Suguru +3 more
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Diacylglycerol kinases: Relationship to other lipid kinases [PDF]
Advances in Biological Regulation, 2019 Lipid kinases regulate a wide variety of cellular functions and have emerged as one the most promising targets for drug design. Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the ATP-dependent phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PtdOH).
Qianqian, Ma +2 more
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Diacylglycerol Kinases in the Coordination of Synaptic Plasticity [PDF]
Frontiers in Cell and Developmental Biology, 2016 Synaptic plasticity is activity-dependent modification of the efficacy of synaptic transmission. Although, detailed mechanisms underlying synaptic plasticity are diverse and vary at different types of synapses, diacylglycerol (DAG)-associated signaling has been considered as an important regulator of many forms of synaptic plasticity, including long ...
Dongwon Lee +3 more
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Cochlioquinone A, an Inhibitor of Diacylglycerol Kinase.
The Journal of Antibiotics, 1995 The effects of cochlioquinone A, isolated from Drechslera sacchari, were studied in vitro and in vivo. This compound specifically inhibited diacylglycerol kinase activity with Ki = 3.1 microM. The kinetics revealed that cochlioquinone A inhibited diacylglycerol kinase in competition with ATP, and non-competitively with diacylglycerol.
T, Machida, K, Higashi, H, Ogawara
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Signaling roles of diacylglycerol kinases [PDF]
Journal of Cellular Biochemistry, 2005 AbstractDiacylglycerol kinases (DGKs) attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid (PA). The nine mammalian DGKs that have been identified are widely expressed, but each isoform has a unique tissue and subcellular distribution.
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Endocannabinoids and diacylglycerol kinase activity
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011 Mammalian diacylglycerol kinases are a family of enzymes that catalyze the phosphorylation of diacylglycerol to produce phosphatidic acid. The extent of interaction of these enzymes with monoacylglycerols is the focus of the present study. Because of the structural relationship between mono- and diacylglycerols, one might expect the monoacylglycerols ...
Gantayet, Arpita +4 more
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Diacylglycerol Kinase Delta Promotes Lipogenesis [PDF]
Biochemistry, 2013 We have studied the relationship between diacylglycerol kinase delta (DGKδ) and lipogenesis. There is a marked increase in the expression of DGKδ during the differentiation of 3T3-L1 cells to adipocytes, as well as in the synthesis of neutral and polar lipids.
Yulia V, Shulga +12 more
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