Results 1 to 10 of about 539,017 (238)

Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis

Biological Research, 2002
Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous.
MARCIA M. WRIGHT, CHRISTOPHER R. MCMASTER   +1 more
doaj  

Diglyceride kinase in human platelets

Journal of Lipid Research, 1973
Human platelets contain diglyceride kinase, an enzyme that catalyzes the phosphorylation of diacylglycerol by adenosine 5′-triphosphate to yield phosphatidic acid.
Frank L. Call, II, Mary Rubert
doaj   +1 more source

Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity

Frontiers in Synaptic Neuroscience, 2022
Lipids and their metabolic enzymes are a critical point of regulation for the membrane curvature required to induce membrane fusion during synaptic vesicle recycling.
Casey N. Barber, Casey N. Barber, Hana L. Goldschmidt, Qianqian Ma, Lauren R. Devine, Robert N. Cole, Richard L. Huganir, Daniel M. Raben   +7 more
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Diacylglycerol kinases (DGKs): novel targets for improving T cell activity in cancer

Frontiers in Cell and Developmental Biology, 2016
Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the metabolism of diacylglycerol (DAG). Two isoforms of DGK, DGKα and DGKζ, specifically regulate the pool of DAG that is generated as a second messenger after stimulation of the T cell ...
Matthew Riese, Matthew Riese, Edmund Moon, Bryon Johnson, Steven Albelda   +4 more
doaj   +1 more source

Nuclear inositides

European Journal of Histochemistry, 2009
DAG, 1,2-diacylglycerol; EGF, epidermal growth factor; TNF, tumour necrosis factor; IGF-I, insulinlike growth factor I; Ins(n)P, inositol phosphate; Ins(n,n)P2, inositol bisphosphate; Ins(n,n,n)P3, inositol trisphosphate; MEL, murine erythroleukemia ...
C D'Santos, JH Clarke, M Roefs, JR Halstead, N Divecha   +4 more
doaj   +3 more sources

A protocol for measuring the activity of protein kinase C-delta in murine bone-marrow-derived dendritic cells

STAR Protocols
Summary: Protein kinase C-δ (PKC-δ) is a key enzyme controlling growth, differentiation, and apoptosis in various cells, including immune cells.
Seyedeh Mahdiye Mohati, Arash Mohammadi Matak, Stephanie Makdissi, Francesca Di Cara   +3 more
doaj   +1 more source

cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1

Journal of Lipid Research, 2013
Diacylglycerol kinase (DGK)θ is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid (PA). We have previously shown that PA is a ligand for the nuclear receptor steroidogenic factor 1 (SF1) and that cAMP-stimulated expression of ...
Kai Cai, Marion B. Sewer
doaj   +1 more source

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

Lipids in Health and Disease, 2020
Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes.
Katarzyna Kolczynska, Angel Loza-Valdes, Izabela Hawro, Grzegorz Sumara   +3 more
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Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.

PLoS ONE, 2019
Subsets of small-diameter dorsal root ganglia (DRG) neurons detect pruritogenic (itch-causing) and algogenic (pain-causing) stimuli and can be activated or sensitized by chemical mediators.
Victoria Brings Bartsch, Jesse K Niehaus, Bonnie Taylor-Blake, Mark J Zylka   +3 more
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Signaling at the membrane interface by the DGK/SK enzyme family

Journal of Lipid Research, 2009
The sphingosine (SK) and diacylglycerol (DGK) kinases have become the subject of considerable focus recently due to their involvement as signaling enzymes in a variety of important biological processes.
Daniel M. Raben, Binks W. Wattenberg
doaj   +1 more source