Diacylglycerol kinase η colocalizes and interacts with apoptosis signal-regulating kinase 3 in response to osmotic shock [PDF]
Biochemistry and Biophysics Reports, 2021 Diacylglycerol kinase (DGK) η translocates from the cytoplasm to punctate vehicles via osmotic shock. Apoptosis signal-regulating kinase (ASK) 3 (MAP kinase kinase kinase (MAPKKK) 15) is also reported to respond to osmotic shock.
Yuji Suzuki +3 more
doaj +2 more sources
Editorial: Diacylglycerol Kinase Signalling [PDF]
Frontiers in Cell and Developmental Biology, 2017 Isabel Merida +3 more
doaj +5 more sources
Diacylglycerol kinase δ is required for skeletal muscle development and regeneration [PDF]
FASEB BioAdvancesDiacylglycerol kinase δ (DGKδ) phosphorylates diacylglycerol to produce phosphatidic acid. Previously, we demonstrated that down‐regulation of DGKδ suppresses the myogenic differentiation of C2C12 myoblasts.
Hiromichi Sakai +4 more
doaj +2 more sources
Lipid phosphorylation by a diacylglycerol kinase suppresses ABA biosynthesis to regulate plant stress responses [PDF]
Molecular PlantSang-Chul Kim +2 more
exaly +2 more sources
DGKζ exerts greater control than DGKα over CD8+ T cell activity and tumor inhibition
OncoImmunology, 2021 Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T cells.
Junchen Gu +11 more
doaj +1 more source
SEC14 phospholipid transfer protein is involved in lipid signaling-mediated plant immune responses in Nicotiana benthamiana. [PDF]
PLoS ONE, 2014 We previously identified a gene related to the SEC14-gene phospholipid transfer protein superfamily that is induced in Nicotiana benthamiana (NbSEC14) in response to infection with Ralstonia solanacearum. We here report that NbSEC14 plays a role in plant
Akinori Kiba +5 more
doaj +1 more source
Prokaryotic Diacylglycerol Kinase and Undecaprenol Kinase [PDF]
Annual Review of Biophysics, 2012 Prokaryotic diacylglycerol kinase (DAGK) and undecaprenol kinase (UDPK) are the lone members of a family of multispan membrane enzymes that are very small, lack relationships to any other family of proteins—including water soluble kinases—and exhibit an unusual structure and active site architecture.
Wade D, Van Horn, Charles R, Sanders
openaire +2 more sources
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Diacylglycerol Kinases in Signal Transduction
International Journal of Molecular Sciences, 2022 In recent years, the significant research efforts put into the clarification of the PI3K/AKT/mTOR pathway resulted in the approval of the first targeted therapies based on lipid kinase inhibitors [...]
Sara Centonze, Gianluca Baldanzi
openaire +3 more sources
Scientific Reports, 2023 Stimulation of glucose uptake in response to ischemic metabolic stress is important for cardiomyocyte function and survival. Chronic exposure of cardiomyocytes to fatty acids (FA) impairs the stimulation of glucose uptake, whereas induction of lipid ...
Ettore Vanni +3 more
doaj +1 more source