Results 21 to 30 of about 441 (94)

Diacylglycerol generated in CHO cell plasma membrane by phospholipase C is used for triacylglycerol synthesis

Journal of Lipid Research, 2001
The diacylglycerol (DAG) signal generated from membrane phospholipids by hormone-activated phospholipases is attenuated by mechanisms that include lipolysis or phospholipid resynthesis.
R. Ariel Igal, J. Matías Caviglia, I. Nelva T. de Gómez Dumm, Rosalind A. Coleman   +3 more
doaj   +1 more source

Structure of membrane diacylglycerol kinase in lipid bilayers

Communications Biology, 2021
Jianping Li et al. present the homo-trimeric structure of the small integral membrane protein diacylglycerol kinase (DgkA) in phospholipid bilayers determined by magic angle spinning solid-state NMR spectroscopy.
Jianping Li, Yang Shen, Yanke Chen, Zhengfeng Zhang, Shaojie Ma, Qianfen Wan, Qiong Tong, Clemens Glaubitz, Maili Liu, Jun Yang   +9 more
doaj   +1 more source

Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver.

Journal of Lipid Research, 1986
The stereospecificity of monoacylglycerol acyltransferase from rat intestinal mucosa and suckling rat liver microsomes was examined using sn-1,2-diacylglycerol kinase from Escherichia coli.
R A Coleman, J P Walsh, D S Millington, D A Maltby   +3 more
doaj   +1 more source

Quantitative Analysis of Cellular Diacylglycerol Content

Bio-Protocol, 2014
Diacylglycerol (DAG) is a bioactive lipid with diverse biological roles. DAG transiently accumulates in a membrane upon receipt of an appropriate stimulus that activates phospholipase C to cleave phospholipids.
Fikadu Tafesse, Karin Strijbis, Hidde Ploegh   +2 more
doaj   +1 more source

DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2

Cell Death and Disease, 2022
Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening of a CRISPR-Cas9 knockout library containing
Yuanyuan Zhao, Hefen Sun, Xuan Li, Qiqi Liu, Yang Liu, Yifeng Hou, Wei Jin   +6 more
doaj   +1 more source

Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. [PDF]

PLoS ONE, 2010
Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKβ is widely distributed in the central nervous system, such as the olfactory bulb, cerebral cortex, striatum, and hippocampus.
Kenichi Kakefuda, Atsushi Oyagi, Mitsue Ishisaka, Kazuhiro Tsuruma, Masamitsu Shimazawa, Koichi Yokota, Yasuhito Shirai, Kyoji Horie, Naoaki Saito, Junji Takeda, Hideaki Hara   +10 more
doaj   +1 more source

Dual effect of reduced type I diacylglycerol kinase activity on insulin secretion from MIN6 β-cells

Journal of Pharmacological Sciences, 2019
The role of type I diacylglycerol kinases (DGKs) in the regulation of insulin secretion was investigated in MIN6 β-cells. In intracellular Ca2+ concentration ([Ca2+]i) measurement experiments, 1 μM R59949, a type I DGK inhibitor, and 10 μM DiC8, a ...
Toshiaki Sawatani, Yukiko K. Kaneko, Tomohisa Ishikawa   +2 more
doaj   +1 more source

Lipid second messengers and related enzymes in vertebrate rod outer segments

Journal of Lipid Research, 2010
Rod outer segments (ROSs) are specialized light-sensitive organelles in vertebrate photoreceptor cells. Lipids in ROS are of considerable importance, not only in providing an adequate environment for efficient phototransduction, but also in originating ...
Norma M. Giusto, Susana J. Pasquaré, Gabriela A. Salvador, Mónica G. Ilincheta de Boschero   +3 more
doaj   +1 more source

Diacylglycerol Kinase-ε: Properties and Biological Roles

Frontiers in Cell and Developmental Biology, 2016
In mammals there are at least 10 isoforms of diacylglycerol kinases (DGK). All catalyze the phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PA). Among DGK isoforms, DGKε has several unique features.
Richard M Epand, Vincent So, Vincent So, William Jennings, Bijendra Khadka, Radhey S. Gupta, Mathieu Lemaire, Mathieu Lemaire   +7 more
doaj   +1 more source

Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. [PDF]

PLoS ONE, 2013
Invariant natural killer T (iNKT) cells play important roles in bridging innate and adaptive immunity via rapidly producing a variety of cytokines. A small subset of iNKT cells produces IL-17 and is generated in the thymus during iNKT-cell ontogeny.
Jinhong Wu, Shudan Shen, Jialong Yang, Zhenwei Xia, Xiao-Ping Zhong   +4 more
doaj   +1 more source