DGKζ exerts greater control than DGKα over CD8+ T cell activity and tumor inhibition
OncoImmunology, 2021 Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T cells.
Junchen Gu +11 more
doaj +1 more source
Lipid phosphorylation by a diacylglycerol kinase suppresses ABA biosynthesis to regulate plant stress responses [PDF]
Molecular PlantJianwu Li, Sang-Chul Kim, Xuemin Wang
exaly +2 more sources
Prokaryotic Diacylglycerol Kinase and Undecaprenol Kinase [PDF]
Annual Review of Biophysics, 2012 Prokaryotic diacylglycerol kinase (DAGK) and undecaprenol kinase (UDPK) are the lone members of a family of multispan membrane enzymes that are very small, lack relationships to any other family of proteins—including water soluble kinases—and exhibit an unusual structure and active site architecture.
Wade D, Van Horn, Charles R, Sanders
openaire +2 more sources
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Diacylglycerol Kinases in Signal Transduction
International Journal of Molecular Sciences, 2022 In recent years, the significant research efforts put into the clarification of the PI3K/AKT/mTOR pathway resulted in the approval of the first targeted therapies based on lipid kinase inhibitors [...]
Sara Centonze, Gianluca Baldanzi
openaire +3 more sources
Scientific Reports, 2023 Stimulation of glucose uptake in response to ischemic metabolic stress is important for cardiomyocyte function and survival. Chronic exposure of cardiomyocytes to fatty acids (FA) impairs the stimulation of glucose uptake, whereas induction of lipid ...
Ettore Vanni +3 more
doaj +1 more source
RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth
Biomolecules, 2021 Diacylglycerol kinase β (DGKβ) is an enzyme that converts diacylglycerol to phosphatidic acid and is mainly expressed in the cerebral cortex, hippocampus and striatum.
Takuya Kano +7 more
doaj +1 more source
The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei [PDF]
, 2014 Funded by Wellcome Trust: Senior Research Fellowship, Grant Number: 067441 and Wellcome Trust, Grant Numbers: 082596, 093228.Lipid metabolism in Trypanosoma brucei, the causative agent of African sleeping sickness, differs from its human host in several ...
Lilley, Alison C. +7 more
core +1 more source
The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice
Journal of Pharmacological Sciences, 2014 Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. To date, 10 isoforms of DGKs (α, β, γ, δ, ε, ζ, η, θ, ι, and κ) have been identified in mammals, and these DGKs show characteristic expression patterns and roles.
Mitsue Ishisaka, Hideaki Hara
doaj +1 more source
Phosphatidic acid production regulated by receptors with liganddependent tyrosine kinase activity
Grasas y Aceites, 1995 The present study deals with the most recent and important studies on the relationship between transmembrane receptors with ligand-dependent tyrosine kinase activity and cellular lipid metabolism, predominantly in generating phosphatidic acid (PA) as a ...
Fco. J. G. Muriana, V. Ruiz-Gutiérrez
doaj +1 more source