The Immunomodulatory Functions of Diacylglycerol Kinase ζ [PDF]
Frontiers in Cell and Developmental Biology, 2016 The generation of diacylglycerol (DAG) is critical for promoting immune cell activation, regulation, and function. Diacylglycerol kinase ζ (DGKζ) serves as an important negative regulator of DAG by enzymatically converting DAG into phosphatidic acid (PA) to shut down DAG-mediated signaling.
Singh, Brenal K., Kambayashi, Taku
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Editorial: Diacylglycerol Kinase Signalling [PDF]
Frontiers in Cell and Developmental Biology, 2017 Isabel Merida +3 more
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Regulation of Macropinocytosis by Diacylglycerol Kinase ζ
PLOS ONE, 2015 Macropinosomes arise from the closure of plasma membrane ruffles to bring about the non-selective uptake of nutrients and solutes into cells. The morphological changes underlying ruffle formation and macropinosome biogenesis are driven by actin cytoskeleton rearrangements under the control of the Rho GTPase Rac1.
Ryan Ard +6 more
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DGKζ exerts greater control than DGKα over CD8+ T cell activity and tumor inhibition
OncoImmunology, 2021 Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T cells.
Junchen Gu +11 more
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SEC14 phospholipid transfer protein is involved in lipid signaling-mediated plant immune responses in Nicotiana benthamiana. [PDF]
PLoS ONE, 2014 We previously identified a gene related to the SEC14-gene phospholipid transfer protein superfamily that is induced in Nicotiana benthamiana (NbSEC14) in response to infection with Ralstonia solanacearum. We here report that NbSEC14 plays a role in plant
Akinori Kiba +5 more
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Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness
Frontiers in Immunology, 2021 The diacylglycerol kinases (DGKs) are a family of enzymes responsible for the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). In addition to their primary function in lipid metabolism, DGKs have recently been identified as potential ...
Laryssa C. Manigat +7 more
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Scientific Reports, 2023 Stimulation of glucose uptake in response to ischemic metabolic stress is important for cardiomyocyte function and survival. Chronic exposure of cardiomyocytes to fatty acids (FA) impairs the stimulation of glucose uptake, whereas induction of lipid ...
Ettore Vanni +3 more
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RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth
Biomolecules, 2021 Diacylglycerol kinase β (DGKβ) is an enzyme that converts diacylglycerol to phosphatidic acid and is mainly expressed in the cerebral cortex, hippocampus and striatum.
Takuya Kano +7 more
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The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice
Journal of Pharmacological Sciences, 2014 Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. To date, 10 isoforms of DGKs (α, β, γ, δ, ε, ζ, η, θ, ι, and κ) have been identified in mammals, and these DGKs show characteristic expression patterns and roles.
Mitsue Ishisaka, Hideaki Hara
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Phosphatidic acid production regulated by receptors with liganddependent tyrosine kinase activity
Grasas y Aceites, 1995 The present study deals with the most recent and important studies on the relationship between transmembrane receptors with ligand-dependent tyrosine kinase activity and cellular lipid metabolism, predominantly in generating phosphatidic acid (PA) as a ...
Fco. J. G. Muriana, V. Ruiz-Gutiérrez
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