Results 11 to 20 of about 539,017 (238)

The Immunomodulatory Functions of Diacylglycerol Kinase ζ [PDF]

Frontiers in Cell and Developmental Biology, 2016
The generation of diacylglycerol (DAG) is critical for promoting immune cell activation, regulation, and function. Diacylglycerol kinase ζ (DGKζ) serves as an important negative regulator of DAG by enzymatically converting DAG into phosphatidic acid (PA)
Brenal Singh, Taku Kambayashi
doaj   +5 more sources

Endocannabinoids and diacylglycerol kinase activity [PDF]

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
Mammalian diacylglycerol kinases are a family of enzymes that catalyze the phosphorylation of diacylglycerol to produce phosphatidic acid. The extent of interaction of these enzymes with monoacylglycerols is the focus of the present study. Because of the
Arpita Gantayet, Jayakumaran, Gowtham, Gowtham Jayakumaran, Richard M. Epand, Topham, Matthew K., Gantayet, Arpita, Jegatheswaran, Januvi, Matthew K. Topham, Januvi Jegatheswaran, Epand, Richard M.   +9 more
core   +3 more sources

Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness [PDF]

Frontiers in Immunology, 2021
The diacylglycerol kinases (DGKs) are a family of enzymes responsible for the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). In addition to their primary function in lipid metabolism, DGKs have recently been identified as potential ...
Laryssa C. Manigat, Mitchell E. Granade, Suchet Taori, Charlotte Anne Miller, Luke R. Vass, Xiao-Ping Zhong, Thurl E. Harris, Benjamin W. Purow   +7 more
doaj   +2 more sources

Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration [PDF]

Scientific Reports
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to generate phosphatidic acid, which plays important roles in intracellular signal transduction. DGKα is reportedly associated with progression of tumors, including hepatocellular carcinomas, but
Hiroki Nakamoto, Shunsuke Shichi, Chisato Shirakawa, Takuto Suzuki, Hidemitsu Kitamura, Akinobu Taketomi   +5 more
doaj   +2 more sources

Diacylglycerol kinase

, 2010
Diacylglycerol kinase (DGK, EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). DGK belongs to a well-conserved family of proteins found in diverse species, such as Saccharomyces cerevisiae ...
Munnik, T., Arisz, S.A.
core   +3 more sources

Structure of membrane diacylglycerol kinase in lipid bilayers [PDF]

Communications Biology, 2021
Jianping Li et al. present the homo-trimeric structure of the small integral membrane protein diacylglycerol kinase (DgkA) in phospholipid bilayers determined by magic angle spinning solid-state NMR spectroscopy.
Jianping Li, Yang Shen, Yanke Chen, Zhengfeng Zhang, Shaojie Ma, Qianfen Wan, Qiong Tong, Clemens Glaubitz, Maili Liu, Jun Yang   +9 more
doaj   +2 more sources

Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3 [PDF]

Thoracic Cancer, 2023
Background Diacylglycerol kinase α (DGKA) is the first member discovered from the diacylglycerol kinase family, and it has been linked to the progression of various types of tumors. However, it is unclear whether DGKA is linked to the development of lung
Dong Zhou, Tao Liu, Xinrui Rao, Xiaohua Jie, Yunshang Chen, Zilong Wu, Huilin Deng, Dan Zhang, Jian Wang, Gang Wu   +9 more
doaj   +2 more sources

A dual diacylglycerol kinase (DGK) alpha/zeta inhibitor augments the activity of human tumor infiltrating lymphocytes in in vivo and ex vivo models [PDF]

OncoImmunology
Endogenous or adoptively transferred tumor-infiltrating lymphocytes (TILs) often lose their functional capacity due to the activation of intrinsic inhibitory pathways, which then limits their ability to control tumor growth.
Phurin Areesawangkit, Karen Pei-Yi Fong, Emma Niemeyer, Yan Li, Kelly Markowitz, Devora Delman, Ryan Krause, Justine Carl, Pat Feldman, Lisa Troung, Rodrigo Hess, Xiaodi Ren, Cynthia Timmers, Sunkyu Kim, Robert Brody, Sunil Singhal, Jarrod Predina, Evgeniy Eruslanov, Gregory Beatty, Bihui Melidosian, Steven M. Albelda   +20 more
doaj   +2 more sources

Diacylglycerol Kinase ζ Attenuates Doxorubicin‐Induced Cardiotoxicity Through p53 Degradation [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Doxorubicin‐induced cardiotoxicity is still an important medical problem associated with a high mortality rate in cancer survivors. p53 plays a key role in doxorubicin‐induced cardiotoxicity.
Shingo Tachibana, Yoichiro Otaki, Tetsu Watanabe, Jun Goto, Haruki Ochi, Toshiaki Tanaka, Hiroe Ono, Ryuhei Yamaguchi, Junya Sato, Hiroki Takahashi, Takanori Arimoto, Kaoru Goto, Masafumi Watanabe   +12 more
doaj   +2 more sources

Regulation of Macropinocytosis by Diacylglycerol Kinase ζ.

PLoS ONE, 2015
Macropinosomes arise from the closure of plasma membrane ruffles to bring about the non-selective uptake of nutrients and solutes into cells. The morphological changes underlying ruffle formation and macropinosome biogenesis are driven by actin ...
Ryan Ard, Kirk Mulatz, Julia L Pomoransky, Robin J Parks, Laura Trinkle-Mulcahy, John C Bell, Stephen H Gee   +6 more
doaj   +3 more sources