Results 11 to 20 of about 45,123 (293)

The Immunomodulatory Functions of Diacylglycerol Kinase ζ [PDF]

Frontiers in Cell and Developmental Biology, 2016
The generation of diacylglycerol (DAG) is critical for promoting immune cell activation, regulation, and function. Diacylglycerol kinase ζ (DGKζ) serves as an important negative regulator of DAG by enzymatically converting DAG into phosphatidic acid (PA)
Brenal Singh, Taku Kambayashi
doaj   +4 more sources

Diacylglycerol kinase

, 2010
Diacylglycerol kinase (DGK, EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). DGK belongs to a well-conserved family of proteins found in diverse species, such as Saccharomyces cerevisiae ...
Munnik, T., Arisz, S.A.
core   +3 more sources

Endocannabinoids and diacylglycerol kinase activity

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
Mammalian diacylglycerol kinases are a family of enzymes that catalyze the phosphorylation of diacylglycerol to produce phosphatidic acid. The extent of interaction of these enzymes with monoacylglycerols is the focus of the present study. Because of the
Arpita Gantayet, Jayakumaran, Gowtham, Gowtham Jayakumaran, Richard M. Epand, Topham, Matthew K., Gantayet, Arpita, Jegatheswaran, Januvi, Matthew K. Topham, Januvi Jegatheswaran, Epand, Richard M.   +9 more
core   +3 more sources

Molecular analysis of a novel Drosophila diacylglycerol kinase, DGKϵ

Biochimica Et Biophysica Acta - Molecular Cell Research, 2001
Diacylglycerol kinase plays a central role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid thus initiating resynthesis of phosphatidylinositols.
James A Birchler
exaly   +2 more sources

Diacylglycerol kinase control of protein kinase C

Biochemical Journal, 2021
The diacylglycerol kinases (DGK) are lipid kinases that transform diacylglycerol (DAG) into phosphatidic acid (PA) in a reaction that terminates DAG-based signals.
Arranz Nicolás, Javier, Ávila-Flores, Antonia, Mérida, Isabel, Rodríguez-Rodríguez, Cristina   +3 more
core   +4 more sources

Regulation of Macropinocytosis by Diacylglycerol Kinase ζ.

PLoS ONE, 2015
Macropinosomes arise from the closure of plasma membrane ruffles to bring about the non-selective uptake of nutrients and solutes into cells. The morphological changes underlying ruffle formation and macropinosome biogenesis are driven by actin ...
Ryan Ard, Kirk Mulatz, Julia L Pomoransky, Robin J Parks, Laura Trinkle-Mulcahy, John C Bell, Stephen H Gee   +6 more
doaj   +3 more sources

Editorial: Diacylglycerol Kinase Signalling [PDF]

Frontiers in Cell and Developmental Biology, 2017
Isabel Merida, Andrea Graziani, Andrea Graziani, Fumio Sakane   +3 more
doaj   +4 more sources

<i>Staphylococcus aureus</i> uses a GGDEF protein to recruit diacylglycerol kinase to the membrane for lipid recycling. [PDF]

Proc Natl Acad Sci U S A
Mychack A, Evans D, Gilles T, James MJ, Walker S.   +4 more
europepmc   +3 more sources

Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis

Biological Research, 2002
Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous.
MARCIA M. WRIGHT, CHRISTOPHER R. MCMASTER   +1 more
doaj   +1 more source

SEC14 phospholipid transfer protein is involved in lipid signaling-mediated plant immune responses in Nicotiana benthamiana. [PDF]

PLoS ONE, 2014
We previously identified a gene related to the SEC14-gene phospholipid transfer protein superfamily that is induced in Nicotiana benthamiana (NbSEC14) in response to infection with Ralstonia solanacearum. We here report that NbSEC14 plays a role in plant
Akinori Kiba, Ivan Galis, Yuko Hojo, Kouhei Ohnishi, Hirofumi Yoshioka, Yasufumi Hikichi   +5 more
doaj   +1 more source