Results 41 to 50 of about 441 (94)
The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy
Molecules, 2022 The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients’ quality of life and medical expenses.
Daiki Hayashi, Yasuhito Shirai
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European Journal of Histochemistry, 2009 DAG, 1,2-diacylglycerol; EGF, epidermal growth factor; TNF, tumour necrosis factor; IGF-I, insulinlike growth factor I; Ins(n)P, inositol phosphate; Ins(n,n)P2, inositol bisphosphate; Ins(n,n,n)P3, inositol trisphosphate; MEL, murine erythroleukemia ...
C D'Santos +4 more
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Diacylglycerol kinases in the regulation of dendritic spines [PDF]
Journal of Neurochemistry, 2010 J. Neurochem. (2010) 112, 577–587.AbstractDiacylglycerol (DAG) is an important lipid‐signaling molecule that binds and activates various downstream effectors. Tight control over the production and removal of DAG is important in maintaining the dynamic responses of the DAG signaling system to a changing environment.
Kim, K, Yang, J, Kim, E Kim, Eunjoon
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Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3
Thoracic Cancer, 2023 Background Diacylglycerol kinase α (DGKA) is the first member discovered from the diacylglycerol kinase family, and it has been linked to the progression of various types of tumors. However, it is unclear whether DGKA is linked to the development of lung
Dong Zhou +9 more
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Diacylglycerol kinase θ: Regulation and stability [PDF]
Advances in Biological Regulation, 2013 Given the well-established roles of diacylglycerol (DAG) and phosphatidic acid (PtdOH) in a variety of signaling cascades, it is not surprising that there is an increasing interest in understanding their physiological roles and mechanisms that regulate their cellular levels.
Becky, Tu-Sekine +3 more
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Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration
Scientific ReportsDiacylglycerol kinases (DGKs) phosphorylate diacylglycerol to generate phosphatidic acid, which plays important roles in intracellular signal transduction. DGKα is reportedly associated with progression of tumors, including hepatocellular carcinomas, but
Hiroki Nakamoto +5 more
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The Ligand Binding Landscape of Diacylglycerol Kinases [PDF]
Cell Chemical Biology, 2017 Diacylglycerol kinases (DGKs) are integral components of signal transduction cascades that regulate cell biology through ATP-dependent phosphorylation of the lipid messenger diacylglycerol. Methods for direct evaluation of DGK activity in native biological systems are lacking and needed to study isoform-specific functions of these multidomain lipid ...
Caroline E, Franks +4 more
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STAR ProtocolsSummary: Protein kinase C-δ (PKC-δ) is a key enzyme controlling growth, differentiation, and apoptosis in various cells, including immune cells.
Seyedeh Mahdiye Mohati +3 more
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Journal of Lipid Research, 2013 Diacylglycerol kinase (DGK)θ is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid (PA). We have previously shown that PA is a ligand for the nuclear receptor steroidogenic factor 1 (SF1) and that cAMP-stimulated expression of ...
Kai Cai, Marion B. Sewer
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Lipids in Health and Disease, 2020 Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes.
Katarzyna Kolczynska +3 more
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