Results 41 to 50 of about 539,017 (238)
Journal of Lipid Research, 1986 The stereospecificity of monoacylglycerol acyltransferase from rat intestinal mucosa and suckling rat liver microsomes was examined using sn-1,2-diacylglycerol kinase from Escherichia coli.
R A Coleman +3 more
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Quantitative Analysis of Cellular Diacylglycerol Content
Bio-Protocol, 2014 Diacylglycerol (DAG) is a bioactive lipid with diverse biological roles. DAG transiently accumulates in a membrane upon receipt of an appropriate stimulus that activates phospholipase C to cleave phospholipids.
Fikadu Tafesse +2 more
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Cell Death and Disease, 2022 Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening of a CRISPR-Cas9 knockout library containing
Yuanyuan Zhao +6 more
doaj +1 more source
Molecular analysis of a novel Drosophila diacylglycerol kinase, DGKϵ [PDF]
, 2001 Diacylglycerol kinase plays a central role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid thus initiating resynthesis of phosphatidylinositols.
Birchler, James A +5 more
core +1 more source
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. [PDF]
PLoS ONE, 2010 Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKβ is widely distributed in the central nervous system, such as the olfactory bulb, cerebral cortex, striatum, and hippocampus.
Kenichi Kakefuda +10 more
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Diacylglycerol kinases: Relationship to other lipid kinases [PDF]
Advances in Biological Regulation, 2019 Lipid kinases regulate a wide variety of cellular functions and have emerged as one the most promising targets for drug design. Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the ATP-dependent phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PtdOH).
Qianqian, Ma +2 more
openaire +2 more sources
Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks [PDF]
, 2014 The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population.
Goebel, Juergen +3 more
core +1 more source
Dual effect of reduced type I diacylglycerol kinase activity on insulin secretion from MIN6 β-cells
Journal of Pharmacological Sciences, 2019 The role of type I diacylglycerol kinases (DGKs) in the regulation of insulin secretion was investigated in MIN6 β-cells. In intracellular Ca2+ concentration ([Ca2+]i) measurement experiments, 1 μM R59949, a type I DGK inhibitor, and 10 μM DiC8, a ...
Toshiaki Sawatani +2 more
doaj +1 more source
Diacylglycerol Kinases in the Coordination of Synaptic Plasticity [PDF]
Frontiers in Cell and Developmental Biology, 2016 Synaptic plasticity is activity-dependent modification of the efficacy of synaptic transmission. Although, detailed mechanisms underlying synaptic plasticity are diverse and vary at different types of synapses, diacylglycerol (DAG)-associated signaling has been considered as an important regulator of many forms of synaptic plasticity, including long ...
Dongwon Lee +3 more
openaire +3 more sources
Lipid second messengers and related enzymes in vertebrate rod outer segments
Journal of Lipid Research, 2010 Rod outer segments (ROSs) are specialized light-sensitive organelles in vertebrate photoreceptor cells. Lipids in ROS are of considerable importance, not only in providing an adequate environment for efficient phototransduction, but also in originating ...
Norma M. Giusto +3 more
doaj +1 more source