Results 41 to 50 of about 45,123 (293)
Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks [PDF]
, 2014 The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population.
Goebel, Juergen +3 more
core +1 more source
Lipid second messengers and related enzymes in vertebrate rod outer segments
Journal of Lipid Research, 2010 Rod outer segments (ROSs) are specialized light-sensitive organelles in vertebrate photoreceptor cells. Lipids in ROS are of considerable importance, not only in providing an adequate environment for efficient phototransduction, but also in originating ...
Norma M. Giusto +3 more
doaj +1 more source
Role of protein kinase C in renal vasoconstriction caused by angiotensin II [PDF]
, 1990 In this study we have examined the subcellar pathways along which angiotensin II (ANG II) causes renal vasoconstriction. Using the isolated perfused rat kidney model, we found that renal vasoconstriction produced by ANG II (100 pM) was not altered by the
Kurtz, Armin +3 more
core +1 more source
Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis [PDF]
, 2012 Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes.
Zangemeister-Wittke, Uwe +15 more
core +1 more source
Cochlioquinone A, an Inhibitor of Diacylglycerol Kinase.
The Journal of Antibiotics, 1995 The effects of cochlioquinone A, isolated from Drechslera sacchari, were studied in vitro and in vivo. This compound specifically inhibited diacylglycerol kinase activity with Ki = 3.1 microM. The kinetics revealed that cochlioquinone A inhibited diacylglycerol kinase in competition with ATP, and non-competitively with diacylglycerol.
T, Machida, K, Higashi, H, Ogawara
openaire +3 more sources
Signaling roles of diacylglycerol kinases [PDF]
Journal of Cellular Biochemistry, 2005 AbstractDiacylglycerol kinases (DGKs) attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid (PA). The nine mammalian DGKs that have been identified are widely expressed, but each isoform has a unique tissue and subcellular distribution.
openaire +2 more sources
Diacylglycerol Kinase-ε: Properties and Biological Roles
Frontiers in Cell and Developmental Biology, 2016 In mammals there are at least 10 isoforms of diacylglycerol kinases (DGK). All catalyze the phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PA). Among DGK isoforms, DGKε has several unique features.
Richard M Epand +7 more
doaj +1 more source
Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. [PDF]
PLoS ONE, 2013 Invariant natural killer T (iNKT) cells play important roles in bridging innate and adaptive immunity via rapidly producing a variety of cytokines. A small subset of iNKT cells produces IL-17 and is generated in the thymus during iNKT-cell ontogeny.
Jinhong Wu +4 more
doaj +1 more source
Nuclear diacylglycerol kinases: regulation and roles [PDF]
Frontiers in Bioscience, 2007 The diacylglycerol-kinases are a family of related lipid kinases. There are currently 10 known isoforms of diacylglycerol kinases that are categorized into five groups based on similarities in their primary sequence. All of these enzymes catalyze the transfer of the gamma-phosphate of ATP to one lipid second messenger, diacylglycerol, thereby ...
M. Raben Daniel
openalex +3 more sources
MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ. [PDF]
PLoS ONE, 2013 The engagement of the T cell receptor (TCR) induces the generation of diacylglycerol (DAG), an important second messenger activating both the Ras/Erk and PKCθ/NFκB pathways.
Jinwook Shin, Danli Xie, Xiao-Ping Zhong
doaj +1 more source