Results 31 to 40 of about 441 (94)
Cell Reports, 2016 Synaptic transmission relies on coordinated coupling of synaptic vesicle (SV) exocytosis and endocytosis. While much attention has focused on characterizing proteins involved in SV recycling, the roles of membrane lipids and their metabolism remain ...
Hana L. Goldschmidt +5 more
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MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ. [PDF]
PLoS ONE, 2013 The engagement of the T cell receptor (TCR) induces the generation of diacylglycerol (DAG), an important second messenger activating both the Ras/Erk and PKCθ/NFκB pathways.
Jinwook Shin, Danli Xie, Xiao-Ping Zhong
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Arachidonoyl-specific diacylglycerol kinase ε and the endoplasmic reticulum
Frontiers in Cell and Developmental Biology, 2016 The endoplasmic reticulum (ER) comprises an interconnected membrane network, which is made up of lipid bilayer and associated proteins. This organelle plays a central role in the protein synthesis and sorting.
Tomoyuki Nakano +6 more
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Lipid activation of protein kinases
Journal of Lipid Research, 2009 Lipids acutely control the amplitude, duration, and subcellular location of signaling by lipid second messenger-responsive kinases. Typically, this activation is controlled by membrane-targeting modules that allosterically control the function of kinase ...
Alexandra C. Newton
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Biochemistry and Biophysics Reports, 2021 Diacylglycerol kinase (DGK) η translocates from the cytoplasm to punctate vehicles via osmotic shock. Apoptosis signal-regulating kinase (ASK) 3 (MAP kinase kinase kinase (MAPKKK) 15) is also reported to respond to osmotic shock.
Yuji Suzuki +3 more
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Diacylglycerol Kinase Inhibition and Vascular Function [PDF]
Current Enzyme Inhibition, 2009 Diacylglycerol kinases (DGKs), a family of lipid kinases, convert diacylglycerol (DG) to phosphatidic acid (PA). Acting as a second messenger, DG activates protein kinase C (PKC). PA, a signaling lipid, regulates diverse functions involved in physiological responses.
Hyehun, Choi +3 more
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Diacylglycerol kinases as sources of phosphatidic acid [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009 There are ten mammalian diacylglycerol kinases (DGKs) whose primary role is to terminate diacylglycerol (DAG) signaling. However, it is becoming increasingly apparent that DGKs also influence signaling events through their product, phosphatidic acid (PA).
Jinjin, Cai +3 more
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Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis
Biological Research, 2002 Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous.
MARCIA M. WRIGHT +1 more
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Diglyceride kinase in human platelets
Journal of Lipid Research, 1973 Human platelets contain diglyceride kinase, an enzyme that catalyzes the phosphorylation of diacylglycerol by adenosine 5′-triphosphate to yield phosphatidic acid.
Frank L. Call, II, Mary Rubert
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Diacylglycerol kinases (DGKs): novel targets for improving T cell activity in cancer
Frontiers in Cell and Developmental Biology, 2016 Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the metabolism of diacylglycerol (DAG). Two isoforms of DGK, DGKα and DGKζ, specifically regulate the pool of DAG that is generated as a second messenger after stimulation of the T cell ...
Matthew Riese +4 more
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