Results 31 to 40 of about 539,017 (238)

RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth

Biomolecules, 2021
Diacylglycerol kinase β (DGKβ) is an enzyme that converts diacylglycerol to phosphatidic acid and is mainly expressed in the cerebral cortex, hippocampus and striatum.
Takuya Kano, Ryosuke Tsumagari, Akio Nakashima, Ushio Kikkawa, Shuji Ueda, Minoru Yamanoue, Nobuyuki Takei, Yasuhito Shirai   +7 more
doaj   +1 more source

The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei [PDF]

, 2014
Funded by Wellcome Trust: Senior Research Fellowship, Grant Number: 067441 and Wellcome Trust, Grant Numbers: 082596, 093228.Lipid metabolism in Trypanosoma brucei, the causative agent of African sleeping sickness, differs from its human host in several ...
Lilley, Alison C., Smith, Terry K., Smith, Terry K, Young, Simon, Stark, Michael J. R., Lilley, Alison Catherine, Major, Louise Laura, Major, Louise   +7 more
core   +1 more source

The effects of a diacylglycerol kinase inhibitor at mammalian and amphibian neuromuscular junctions in vitro

, 1991
Miniature endplate potentials were studied in mouse phrenic nerve-hemidiaphragm and frog pectoris-cutaneous neuromuscular preparations. The diacylglycerol kinase inhibitor R59022 increased the frequency of miniature endplate potentials in both ...
Publicover, S J, Light, P E, Murphy, R L, Smith, M E   +3 more
core   +6 more sources

Diacylglycerol Kinase alpha in X Linked Lymphoproliferative Disease Type 1. [PDF]

Int J Mol Sci, 2021
Diacylglycerol kinases are intracellular enzymes that control the balance between the secondary messengers diacylglycerol and phosphatidic acid. DGKα and DGKζ are the prominent isoforms that restrain the intensity of T cell receptor signalling by ...
Velnati S, Centonze S, Girivetto F, Baldanzi G.   +3 more
europepmc   +2 more sources

The Roles of Diacylglycerol Kinases in the Central Nervous System: Review of Genetic Studies in Mice

Journal of Pharmacological Sciences, 2014
Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. To date, 10 isoforms of DGKs (α, β, γ, δ, ε, ζ, η, θ, ι, and κ) have been identified in mammals, and these DGKs show characteristic expression patterns and roles.
Mitsue Ishisaka, Hideaki Hara
doaj   +1 more source

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice [PDF]

, 2012
Lung ischaemia–reperfusion-induced oedema (LIRE) is a life-threatening condition that causes pulmonary oedema induced by endothelial dysfunction. Here we show that lungs from mice lacking nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox2y/
Shah, Ajay M., Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Schnitzler, Michael Mederos y, Storch, Ursula, Brandes, Ralf P, Schermuly, Ralph T, Seeger, Werner, Shah, Ajay Mukesh, Veit, Florian, Dietrich, Alexander, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Meissner, Marcel, Pak, Oleg, Brewer, Alison C.; id_orcid, Kalwa, Hermann, Offermanns, Stefan, Ghofrani, Hossein A., Schmidt, Harald H. H. W., Brewer, Alison C, Fuchs, Beate, Ghofrani, Hossein A, Mederos y Schnitzler, Michael, Shah, Ajay M, Krause, Karl-Heinz, Schmidt, Harald H.H.W., Weißmann, Norbert, Gudermann, Thomas, Brewer, Alison C., Schmidt, Harald H H W, Freichel, Marc, Brandes, Ralf P., Schermuly, Ralph Theo   +34 more
core   +1 more source

Phosphatidic acid production regulated by receptors with liganddependent tyrosine kinase activity

Grasas y Aceites, 1995
The present study deals with the most recent and important studies on the relationship between transmembrane receptors with ligand-dependent tyrosine kinase activity and cellular lipid metabolism, predominantly in generating phosphatidic acid (PA) as a ...
Fco. J. G. Muriana, V. Ruiz-Gutiérrez
doaj   +1 more source

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert, Saleh, Sohag N., Albert, Anthony P., Sohag N. Saleh, William A. Large, Large, William A., Large, WA, Saleh, SN, Albert, AP   +8 more
core   +1 more source

Diacylglycerol kinases in membrane trafficking [PDF]

Cellular Logistics, 2015
Diacylglycerol kinases (DGKs) belong to a family of cytosolic kinases that regulate the phosphorylation of diacylglycerol (DAG), converting it into phosphatidic acid (PA). There are 10 known mammalian DGK isoforms, each with a different tissue distribution and substrate specificity.
Shuwei, Xie, Naava, Naslavsky, Steve, Caplan   +2 more
openaire   +2 more sources

Diacylglycerol generated in CHO cell plasma membrane by phospholipase C is used for triacylglycerol synthesis

Journal of Lipid Research, 2001
The diacylglycerol (DAG) signal generated from membrane phospholipids by hormone-activated phospholipases is attenuated by mechanisms that include lipolysis or phospholipid resynthesis.
R. Ariel Igal, J. Matías Caviglia, I. Nelva T. de Gómez Dumm, Rosalind A. Coleman   +3 more
doaj   +1 more source