Results 31 to 40 of about 45,123 (293)

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice [PDF]

, 2012
Lung ischaemia–reperfusion-induced oedema (LIRE) is a life-threatening condition that causes pulmonary oedema induced by endothelial dysfunction. Here we show that lungs from mice lacking nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox2y/
Shah, Ajay M., Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Schnitzler, Michael Mederos y, Storch, Ursula, Brandes, Ralf P, Schermuly, Ralph T, Seeger, Werner, Shah, Ajay Mukesh, Veit, Florian, Dietrich, Alexander, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Meissner, Marcel, Pak, Oleg, Brewer, Alison C.; id_orcid, Kalwa, Hermann, Offermanns, Stefan, Ghofrani, Hossein A., Schmidt, Harald H. H. W., Brewer, Alison C, Fuchs, Beate, Ghofrani, Hossein A, Mederos y Schnitzler, Michael, Shah, Ajay M, Krause, Karl-Heinz, Schmidt, Harald H.H.W., Weißmann, Norbert, Gudermann, Thomas, Brewer, Alison C., Schmidt, Harald H H W, Freichel, Marc, Brandes, Ralf P., Schermuly, Ralph Theo   +34 more
core   +1 more source

Diacylglycerol kinases in membrane trafficking [PDF]

Cellular Logistics, 2015
Diacylglycerol kinases (DGKs) belong to a family of cytosolic kinases that regulate the phosphorylation of diacylglycerol (DAG), converting it into phosphatidic acid (PA). There are 10 known mammalian DGK isoforms, each with a different tissue distribution and substrate specificity.
Shuwei, Xie, Naava, Naslavsky, Steve, Caplan   +2 more
openaire   +2 more sources

Diacylglycerol generated in CHO cell plasma membrane by phospholipase C is used for triacylglycerol synthesis

Journal of Lipid Research, 2001
The diacylglycerol (DAG) signal generated from membrane phospholipids by hormone-activated phospholipases is attenuated by mechanisms that include lipolysis or phospholipid resynthesis.
R. Ariel Igal, J. Matías Caviglia, I. Nelva T. de Gómez Dumm, Rosalind A. Coleman   +3 more
doaj   +1 more source

Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver.

Journal of Lipid Research, 1986
The stereospecificity of monoacylglycerol acyltransferase from rat intestinal mucosa and suckling rat liver microsomes was examined using sn-1,2-diacylglycerol kinase from Escherichia coli.
R A Coleman, J P Walsh, D S Millington, D A Maltby   +3 more
doaj   +1 more source

Quantitative Analysis of Cellular Diacylglycerol Content

Bio-Protocol, 2014
Diacylglycerol (DAG) is a bioactive lipid with diverse biological roles. DAG transiently accumulates in a membrane upon receipt of an appropriate stimulus that activates phospholipase C to cleave phospholipids.
Fikadu Tafesse, Karin Strijbis, Hidde Ploegh   +2 more
doaj   +1 more source

DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2

Cell Death and Disease, 2022
Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening of a CRISPR-Cas9 knockout library containing
Yuanyuan Zhao, Hefen Sun, Xuan Li, Qiqi Liu, Yang Liu, Yifeng Hou, Wei Jin   +6 more
doaj   +1 more source

Diacylglycerol kinases: Relationship to other lipid kinases [PDF]

Advances in Biological Regulation, 2019
Lipid kinases regulate a wide variety of cellular functions and have emerged as one the most promising targets for drug design. Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the ATP-dependent phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PtdOH).
Qianqian, Ma, Sandra B, Gabelli, Daniel M, Raben   +2 more
openaire   +2 more sources

Dual effect of reduced type I diacylglycerol kinase activity on insulin secretion from MIN6 β-cells

Journal of Pharmacological Sciences, 2019
The role of type I diacylglycerol kinases (DGKs) in the regulation of insulin secretion was investigated in MIN6 β-cells. In intracellular Ca2+ concentration ([Ca2+]i) measurement experiments, 1 μM R59949, a type I DGK inhibitor, and 10 μM DiC8, a ...
Toshiaki Sawatani, Yukiko K. Kaneko, Tomohisa Ishikawa   +2 more
doaj   +1 more source

Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. [PDF]

PLoS ONE, 2010
Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKβ is widely distributed in the central nervous system, such as the olfactory bulb, cerebral cortex, striatum, and hippocampus.
Kenichi Kakefuda, Atsushi Oyagi, Mitsue Ishisaka, Kazuhiro Tsuruma, Masamitsu Shimazawa, Koichi Yokota, Yasuhito Shirai, Kyoji Horie, Naoaki Saito, Junji Takeda, Hideaki Hara   +10 more
doaj   +1 more source

Diacylglycerol Kinases in the Coordination of Synaptic Plasticity [PDF]

Frontiers in Cell and Developmental Biology, 2016
Synaptic plasticity is activity-dependent modification of the efficacy of synaptic transmission. Although, detailed mechanisms underlying synaptic plasticity are diverse and vary at different types of synapses, diacylglycerol (DAG)-associated signaling has been considered as an important regulator of many forms of synaptic plasticity, including long ...
Dongwon Lee, Eunjoon Kim, Eunjoon Kim, Keiko Tanaka-Yamamoto   +3 more
openaire   +3 more sources