Results 51 to 60 of about 441 (94)

Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.

PLoS ONE, 2019
Subsets of small-diameter dorsal root ganglia (DRG) neurons detect pruritogenic (itch-causing) and algogenic (pain-causing) stimuli and can be activated or sensitized by chemical mediators.
Victoria Brings Bartsch, Jesse K Niehaus, Bonnie Taylor-Blake, Mark J Zylka   +3 more
doaj   +1 more source

Signaling at the membrane interface by the DGK/SK enzyme family

Journal of Lipid Research, 2009
The sphingosine (SK) and diacylglycerol (DGK) kinases have become the subject of considerable focus recently due to their involvement as signaling enzymes in a variety of important biological processes.
Daniel M. Raben, Binks W. Wattenberg
doaj   +1 more source

The role of diacylglycerol in the exocytosis of the sperm acrosome. Studies using diacylglycerol lipase and diacylglycerol kinase inhibitors and exogenous diacylglycerols [PDF]

Biochemical Journal, 1992
When ram spermatozoa were treated with Ca2+ and the ionophore A23187 to induce acrosomal exocytosis, a rise in diacylglycerol (DAG) mass was observed, concomitant with a rapid breakdown of [32P]P1-labelled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate and a rise in [32P]Pi-labelled phosphatidate. Inclusion of the DAG lipase
E R, Roldan, R A, Harrison
openaire   +2 more sources

Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis

Nature Communications, 2016
Radiotherapy can induce fibrosis in cancer patients, limiting its use in clinical settings. Here, the authors identify a differentially methylated enhancer of the lipid kinase DGKA in fibroblasts from breast cancer patients developing fibrosis after ...
Christoph Weigel, Marlon R. Veldwijk, Christopher C. Oakes, Petra Seibold, Alla Slynko, David B. Liesenfeld, Mariona Rabionet, Sabrina A. Hanke, Frederik Wenz, Elena Sperk, Axel Benner, Christoph Rösli, Roger Sandhoff, Yassen Assenov, Christoph Plass, Carsten Herskind, Jenny Chang-Claude, Peter Schmezer, Odilia Popanda   +18 more
doaj   +1 more source

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse

Molecular Biology of the Cell, 2011
Diacylglycerol (DAG) generation at the T cell immunological synapse (IS) determines the correct activation of antigen-specific immune responses. DAG kinases (DGKs) α and ζ act as negative regulators of DAG-mediated signals by catalyzing DAG conversion to phosphatidic acid (PA). Nonetheless, the specific input of each enzyme and their spatial regulation
Gharbi, Severine I., Rincón, Esther, Avila-Flores, Antonia, Torres-Ayuso, Pedro, Almena, María, Cobos, María Angeles, Albar, Juan Pablo, Mérida, Isabel   +7 more
openaire   +2 more sources

Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol.

Journal of Lipid Research, 1994
Ceramides and phospholipids constitute two important structural lipids of normal skin that are notably rich in polyunsaturated fatty acids. Although linoleic acid (LA) is high in the ceramides, the localization of its 15-lipoxygenase product, 13 ...
Y Cho, V A Ziboh
doaj   +1 more source

Diacylglycerol kinase β promotes dendritic outgrowth and spine maturation in developing hippocampal neurons

BMC Neuroscience, 2009
Background Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol to phosphatidic acid and comprises multiple isozymes of distinct properties.
Otani Koichi, Watanabe Masahiko, Hozumi Yasukazu, Goto Kaoru   +3 more
doaj   +1 more source

Differential regulation of diacylglycerol kinase isoform in human failing hearts

Journal of Cardiothoracic Surgery, 2011
Evidence from several studies indicates the importance of Gαq protein-coupled receptor (GPCR) signaling pathway, which includes diacylglycerol (DAG), and protein kinase C, in the development of heart failure.
Sadahiro Mitsuaki, Kitahara Tatsuro, Sasaki Toshiki, Suzuki Satoshi, Toyama Shuji, Shishido Tetsuro, Bilim Olga, Takeishi Yasuchika, Kubota Isao   +8 more
doaj   +1 more source

Diacylglycerol Kinase Signalling

, 2017
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DG), catalyzing its conversion into phosphatidic acid (PA). This reaction attenuates membrane DG levels, limiting the localization/activation of signaling proteins that bind this lipid. Initially recognized as modulators of classical and novel PKC family members, the function of the DGK has ...
Andrea Graziani, Fumio Sakane, Isabel Merida   +2 more
openaire   +3 more sources

A dual diacylglycerol kinase (DGK) alpha/zeta inhibitor augments the activity of human tumor infiltrating lymphocytes in in vivo and ex vivo models

OncoImmunology
Endogenous or adoptively transferred tumor-infiltrating lymphocytes (TILs) often lose their functional capacity due to the activation of intrinsic inhibitory pathways, which then limits their ability to control tumor growth.
Phurin Areesawangkit, Karen Pei-Yi Fong, Emma Niemeyer, Yan Li, Kelly Markowitz, Devora Delman, Ryan Krause, Justine Carl, Pat Feldman, Lisa Troung, Rodrigo Hess, Xiaodi Ren, Cynthia Timmers, Sunkyu Kim, Robert Brody, Sunil Singhal, Jarrod Predina, Evgeniy Eruslanov, Gregory Beatty, Bihui Melidosian, Steven M. Albelda   +20 more
doaj   +1 more source