Results 51 to 60 of about 45,123 (293)

Ternary structure reveals mechanism of a membrane diacylglycerol kinase [PDF]

, 2015
Diacylglycerol kinase catalyses the ATP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membrane of Escherichia coli. The small size of this integral membrane trimer, which has 121 residues per subunit, means that available ...
R Yefanov, Weierstall, Uwe, Shibom Basu, Kay Diederichs, Keogh, Aaron, Kimberley Rendek, Christopher Kupitz, Gati, Cornelius, Diederichs, Kay, Grotjohann, Ingo, Li, Dianfan, Rendek, Kimberley, Uwe Weierstall, Liu, Wei, Aragao, David, Howe, Nicole, Joseph A. Lyons, Zatsepin, Nadia A., Yefanov, Oleksandr, David Aragao, Ingo Grotjohann, Bandaru, Sateesh, Barty, Anton, Dianfan Li, Boutet, Sébastien, Raimund Fromme, Caffrey, Martin, Cherezov, Vadim, English, Niall J., Vadim Cherezov, Fromme, Petra, M. Marvin Seibert, Nadia A. Zatsepin, Nicole Howe, Petra Fromme, Mark S. P. Sansom, Niall J. English, Aaron Keogh, Cornelius Gati, Basu, Shibom, Vogeley, Lutz, Phillip J. Stansfeld, Anton Barty, Marvin Seibert, M., Chapman, Henry N., Marc Messerschmidt, Lyons, Joseph A., Sateesh B, Henry N. Chapman, Lutz Vogeley, Messerschmidt, Marc, Kupitz, Christopher, Williams, Garth J., Stansfeld, Phillip J., Sansom, Mark S. P., Martin Caffrey, Fromme, Raimund, Garth J. Williams, Wei Liu   +58 more
core   +3 more sources

DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses

Cell Reports, 2016
Synaptic transmission relies on coordinated coupling of synaptic vesicle (SV) exocytosis and endocytosis. While much attention has focused on characterizing proteins involved in SV recycling, the roles of membrane lipids and their metabolism remain ...
Hana L. Goldschmidt, Becky Tu-Sekine, Lenora Volk, Victor Anggono, Richard L. Huganir, Daniel M. Raben   +5 more
doaj   +1 more source

Arachidonoyl-specific diacylglycerol kinase ε and the endoplasmic reticulum

Frontiers in Cell and Developmental Biology, 2016
The endoplasmic reticulum (ER) comprises an interconnected membrane network, which is made up of lipid bilayer and associated proteins. This organelle plays a central role in the protein synthesis and sorting.
Tomoyuki Nakano, Hirooki Matsui, Toshiaki Tanaka, Yasukazu Hozumi, Ken Iseki, Kaneyuki Kawamae, Kaoru Goto   +6 more
doaj   +1 more source

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Anthony P. Albert, Saleh, Sohag N., Albert, Anthony P., Sohag N. Saleh, William A. Large, Large, William A., Large, WA, Saleh, SN, Albert, AP   +8 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Diacylglycerol Kinase Delta Promotes Lipogenesis [PDF]

Biochemistry, 2013
We have studied the relationship between diacylglycerol kinase delta (DGKδ) and lipogenesis. There is a marked increase in the expression of DGKδ during the differentiation of 3T3-L1 cells to adipocytes, as well as in the synthesis of neutral and polar lipids.
Yulia V, Shulga, Dessi, Loukov, Pavlina T, Ivanova, Stephen B, Milne, David S, Myers, Grant M, Hatch, G, Umeh, Divyanshi, Jalan, Morgan D, Fullerton, Gregory R, Steinberg, Matthew K, Topham, H Alex, Brown, Richard M, Epand   +12 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Lipid activation of protein kinases

Journal of Lipid Research, 2009
Lipids acutely control the amplitude, duration, and subcellular location of signaling by lipid second messenger-responsive kinases. Typically, this activation is controlled by membrane-targeting modules that allosterically control the function of kinase ...
Alexandra C. Newton
doaj   +1 more source

The Diacylglycerol kinase alpha is a key regulator of epithelial cells polarization [PDF]

, 2014
During these three years of PhD fellowships I have been studying how the lipid kinase Diacylglycerol kinase alpha regulates epithelial cells polarization. All the results were obtained under the supervision of Prof. Andrea Graziani, in the laboratory of
BETTIO, VALENTINA
core   +1 more source