Results 71 to 80 of about 441 (94)
Function of diacylglycerol kinase ^|^beta; in neurons
Folia Pharmacologica Japonica, 2014 openaire +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Cellular Signalling, 2004
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In most cases, members of this large family of enzymes appear to bind and regulate proteins activated by either diacylglycerol or phosphatidic acid. Proteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol ...
Bai, Luo +3 more
openaire +2 more sources
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In most cases, members of this large family of enzymes appear to bind and regulate proteins activated by either diacylglycerol or phosphatidic acid. Proteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol ...
Bai, Luo +3 more
openaire +2 more sources
Diacylglycerol kinases in cancer
Advances in Biological Regulation, 2017Diacylglycerol kinases (DGK) are a family of enzymes that catalyze the transformation of diacylglycerol into phosphatidic acid. In T lymphocytes, DGKα and ζ limit the activation of the PLCγ/Ras/ERK axis, providing a critical checkpoint to inhibit T cell responses. Upregulation of these isoforms limits Ras activation, leading to hypo-responsive, anergic
Isabel Mérida +7 more
openaire +2 more sources
2009
Diacylglycerol kinase (DGK, EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). DGK belongs to a well-conserved family of proteins found in diverse species, such as Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, mammals, plants, and bacteria (Merida et al.
Arisz, S.A., Munnik, T.
openaire +2 more sources
Diacylglycerol kinase (DGK, EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). DGK belongs to a well-conserved family of proteins found in diverse species, such as Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, mammals, plants, and bacteria (Merida et al.
Arisz, S.A., Munnik, T.
openaire +2 more sources
Properties and functions of diacylglycerol kinases
Cellular Signalling, 2000Diacylglycerol kinases (DGKs) phosphorylate the second-messenger diacylglycerol (DAG) to phosphatidic acid (PA). The family of DGKs is well conserved among most species. Nine mammalian isotypes have been identified, and are classified into five subgroups based on their primary structure.
W J, van Blitterswijk, B, Houssa
openaire +2 more sources
Diacylglycerol kinases in signal transduction
Chemistry and Physics of Lipids, 1999Diacylglycerol kinase (DGK) phosphorylates the second messenger diacylglycerol (DAG) to phosphatidic acid. A family of nine mammalian isotypes have been identified. Their primary structure shows a diverse array of conserved domains, such as a catalytic domain, zinc fingers, pleckstrin homology domains and EF-hand structures, known to interact with ...
W J, van Blitterswijk, B, Houssa
openaire +2 more sources
An endogenous regulator of diacylglycerol kinase
Biochemical and Biophysical Research Communications, 1988During the initial steps of the subcellular fractionation of rat brain homogenate, we recovered more than 100% of diacylglycerol kinase activity. The unusually high yields prompted us to examine the possibility that we had removed an endogenous inhibitor from diacylglycerol kinase during those steps.
I M, Jeng, N, Klemm, C Z, Wu
openaire +2 more sources
Diacylglycerol kinase control of protein kinase C
Biochemical Journal, 2019Abstract The diacylglycerol kinases (DGK) are lipid kinases that transform diacylglycerol (DAG) into phosphatidic acid (PA) in a reaction that terminates DAG-based signals. DGK provide negative regulation to conventional and novel protein kinase C (PKC) enzymes, limiting local DAG availability in a tissue- and subcellular-restricted ...
Isabel Mérida +3 more
openaire +3 more sources
1996
Abstract Diacylglycerol kinase (DGK) reverses the normal flow of phospholipid biosynthesis by phosphory/ating diacylglycerol back to phosphatidic acid. DGK consists of a number of isozymes with different enzymological properties. The three isozymes so far sequenced, however, share highly conserved regions including two sets each of EF-
openaire +1 more source
Abstract Diacylglycerol kinase (DGK) reverses the normal flow of phospholipid biosynthesis by phosphory/ating diacylglycerol back to phosphatidic acid. DGK consists of a number of isozymes with different enzymological properties. The three isozymes so far sequenced, however, share highly conserved regions including two sets each of EF-
openaire +1 more source