Results 71 to 80 of about 45,123 (293)
Chemistry – A European Journal, EarlyView.Nucleotide‐detected solid‐state NMR has been applied to probe nucleotide conformations and dynamics during ATP hydrolysis using the dimeric P‐loop ATPase SmsC as a model protein. The different stages of ATP hydrolysis have been mimicked by ATP analogues for which different degrees of conformational heterogeneity have been observed. ABSTRACT Solid‐state
Nina Wehr +7 more
wiley +1 more source
Diacylglycerol kinases (DGKs): novel targets for improving T cell activity in cancer
Frontiers in Cell and Developmental Biology, 2016 Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the metabolism of diacylglycerol (DAG). Two isoforms of DGK, DGKα and DGKζ, specifically regulate the pool of DAG that is generated as a second messenger after stimulation of the T cell ...
Matthew Riese +4 more
doaj +1 more source
Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity
Frontiers in Synaptic Neuroscience, 2022 Lipids and their metabolic enzymes are a critical point of regulation for the membrane curvature required to induce membrane fusion during synaptic vesicle recycling.
Casey N. Barber +7 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le +8 more
wiley +1 more source
Diacylglycerol kinases in the regulation of dendritic spines [PDF]
Journal of Neurochemistry, 2010 J. Neurochem. (2010) 112, 577–587.AbstractDiacylglycerol (DAG) is an important lipid‐signaling molecule that binds and activates various downstream effectors. Tight control over the production and removal of DAG is important in maintaining the dynamic responses of the DAG signaling system to a changing environment.
Kim, K, Yang, J, Kim, E Kim, Eunjoon
openaire +3 more sources
European Journal of Histochemistry, 2009 DAG, 1,2-diacylglycerol; EGF, epidermal growth factor; TNF, tumour necrosis factor; IGF-I, insulinlike growth factor I; Ins(n)P, inositol phosphate; Ins(n,n)P2, inositol bisphosphate; Ins(n,n,n)P3, inositol trisphosphate; MEL, murine erythroleukemia ...
C D'Santos +4 more
doaj +3 more sources
Ks1, an epithelial cell-specific gene, responds to early signals of head formation in Hydra [PDF]
, 1994 As a molecular marker for head specification in Hydra, we have cloned an epithelial cell-specific gene which responds to early signals of head formation.
Weinziger, Ruth +3 more
core
, 2002 Diacylglycerol is an essential second messenger in mammalian cells. The most prominent intracellular targets of diacylglycerol and of the functionally analogous phorbol esters belong to the protein kinase C (PKC) family.
Brose, Nils, Brose, N., Rosenmund, C.
core +1 more source
Diacylglycerol kinase θ: Regulation and stability [PDF]
Advances in Biological Regulation, 2013 Given the well-established roles of diacylglycerol (DAG) and phosphatidic acid (PtdOH) in a variety of signaling cascades, it is not surprising that there is an increasing interest in understanding their physiological roles and mechanisms that regulate their cellular levels.
Becky, Tu-Sekine +3 more
openaire +2 more sources
Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals
, 1998 The specificity of many signal transduction pathways relies on the temporal coordination of different second messenger signals. Here we found a molecular mechanism which guarantees that conventional protein kinase C (PKC) isoforms are sequentially ...
Meyer, Tobias, Oancea, Elena
core +1 more source