Results 81 to 90 of about 45,123 (293)

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

The Ligand Binding Landscape of Diacylglycerol Kinases [PDF]

Cell Chemical Biology, 2017
Diacylglycerol kinases (DGKs) are integral components of signal transduction cascades that regulate cell biology through ATP-dependent phosphorylation of the lipid messenger diacylglycerol. Methods for direct evaluation of DGK activity in native biological systems are lacking and needed to study isoform-specific functions of these multidomain lipid ...
Caroline E, Franks, Sean T, Campbell, Benjamin W, Purow, Thurl E, Harris, Ku-Lung, Hsu   +4 more
openaire   +2 more sources

A protocol for measuring the activity of protein kinase C-delta in murine bone-marrow-derived dendritic cells

STAR Protocols
Summary: Protein kinase C-δ (PKC-δ) is a key enzyme controlling growth, differentiation, and apoptosis in various cells, including immune cells.
Seyedeh Mahdiye Mohati, Arash Mohammadi Matak, Stephanie Makdissi, Francesca Di Cara   +3 more
doaj   +1 more source

Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.

PLoS ONE, 2019
Subsets of small-diameter dorsal root ganglia (DRG) neurons detect pruritogenic (itch-causing) and algogenic (pain-causing) stimuli and can be activated or sensitized by chemical mediators.
Victoria Brings Bartsch, Jesse K Niehaus, Bonnie Taylor-Blake, Mark J Zylka   +3 more
doaj   +1 more source

cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1

Journal of Lipid Research, 2013
Diacylglycerol kinase (DGK)θ is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid (PA). We have previously shown that PA is a ligand for the nuclear receptor steroidogenic factor 1 (SF1) and that cAMP-stimulated expression of ...
Kai Cai, Marion B. Sewer
doaj   +1 more source

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

Lipids in Health and Disease, 2020
Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes.
Katarzyna Kolczynska, Angel Loza-Valdes, Izabela Hawro, Grzegorz Sumara   +3 more
doaj   +1 more source

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae, Yun‐Jeong Seo, Eun‐Bi Kim, Hyoung‐Min Park, I‐Hsuan Liu, J. Eugene Lee, Jae‐Young Kim   +6 more
wiley   +1 more source

Increased protein synthesis response to insulin in fibroblasts treated with the diacylglycerol kinase inhibitor R59022

, 1988
Insulin stimulated protein synthesis in quiescent 3T3 fibroblasts. This effect of the hormone was greater in the presence of the diacylglycerol kinase inhibitor R59022 (10−5M) over a range of insulin concentrations from 1μU to 1 mU/ml; R59022 increased ...
Norma McKenzie, Hesketh, John E., Gillian P. Campbell, John E. Hesketh, McKenzie, Norma, Campbell, Gillian P.   +5 more
core   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, EarlyView.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

Comparative analysis of PDZ-binding motifs in the diacylglycerol kinase family [PDF]

, 2023
Boglárka Zámbó, Gergő Gógl, Bastien Morlet, Pascal Eberling, Luc Négroni, Hervé Moine, Gilles Travé   +6 more
openalex   +1 more source