Results 81 to 90 of about 539,017 (238)

The Diacylglycerol kinase alpha is a key regulator of epithelial cells polarization [PDF]

, 2014
During these three years of PhD fellowships I have been studying how the lipid kinase Diacylglycerol kinase alpha regulates epithelial cells polarization. All the results were obtained under the supervision of Prof. Andrea Graziani, in the laboratory of
BETTIO, VALENTINA
core   +1 more source

Novel lipid derivatives for health benefits [PDF]

, 2013
Obesity is a public health concern and requires effective management with multiple approaches. Dietary supplements of bioactive compounds that can improve fatty acid oxidation and thermogenesis are currently in focus to develop anti-obese food ...
Madawala, Samanthi R. P.
core   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Amplification of Diacylglycerol Activation of Protein Kinase C by Cholesterol [PDF]

, 2008
The combined effects of cholesterol, a major cell membrane component, and the lipid second messenger diacylglycerol on the activity of protein kinase C (PK-C) and the structure of phosphatidylcholine/phosphatidylserine bilayers were investigated using ...
Zidovetzki, Raphael, Armstrong, Don
core   +1 more source

Diacylglycerol kinases in the regulation of dendritic spines [PDF]

Journal of Neurochemistry, 2010
J. Neurochem. (2010) 112, 577–587.AbstractDiacylglycerol (DAG) is an important lipid‐signaling molecule that binds and activates various downstream effectors. Tight control over the production and removal of DAG is important in maintaining the dynamic responses of the DAG signaling system to a changing environment.
Kim, K, Yang, J, Kim, E Kim, Eunjoon
openaire   +3 more sources

The genetic landscape of congenital diarrheas and very early onset inflammatory bowel disease in the Middle East

JPGN Reports, EarlyView.
Abstract Objectives Monogenic causes of congenital diarrheas and enteropathies (CoDE) and very early onset inflammatory bowel disease (VEOIBD) are mostly recessive and therefore more prevalent in populations with increased consanguinity rates. To assess the genetic basis of these disorders in a likely high‐prevalence population, we established a multi ...
Lily Gillette, Muna Al Safar, Ganeshwaran H. Mochida, Casey Johnson, Stephen Babcock, Klaus Schmitz‐Abe, Michael Field, Jessica Yang, Richelle Bearup, Ahmed Megahed, Mohammed Ezz El Regal Abbas, Tarek Baraket, Sherine Elziny, Ali Sobh, Gulin Eren, Fawaz AlRefaee, Rana Bitar, Mohamed Miqdady, Pankaj B. Agrawal, Scott B. Snapper, Jay R. Thiagarajah, Jodie Ouahed   +21 more
wiley   +1 more source

Diacylglycerol kinase θ: Regulation and stability [PDF]

Advances in Biological Regulation, 2013
Given the well-established roles of diacylglycerol (DAG) and phosphatidic acid (PtdOH) in a variety of signaling cascades, it is not surprising that there is an increasing interest in understanding their physiological roles and mechanisms that regulate their cellular levels.
Becky, Tu-Sekine, Hana, Goldschmidt, Elizabeth, Petro, Daniel M, Raben   +3 more
openaire   +2 more sources

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Ultraviolet Light Irradiation Increases Cellular Diacylglycerol and Induces Translocation of Diacylglycerol Kinase in Murine Keratinocytes [PDF]

, 1992
Cellular lipid metabolism can provide a variety of mediators of signal transduction, including diacylglycerols and inositol Phosphates. These factors may be involved in the control of epidermal differentiation and proliferation because they are modulated
Stuart H. Yuspa, Punnonen, Kari, Kari Punnonen, Yuspa, Stuart H.   +3 more
core   +1 more source

The Ligand Binding Landscape of Diacylglycerol Kinases [PDF]

Cell Chemical Biology, 2017
Diacylglycerol kinases (DGKs) are integral components of signal transduction cascades that regulate cell biology through ATP-dependent phosphorylation of the lipid messenger diacylglycerol. Methods for direct evaluation of DGK activity in native biological systems are lacking and needed to study isoform-specific functions of these multidomain lipid ...
Caroline E, Franks, Sean T, Campbell, Benjamin W, Purow, Thurl E, Harris, Ku-Lung, Hsu   +4 more
openaire   +2 more sources