Results 61 to 70 of about 441 (94)

Pharmacological Evidence for Involvement of Phospholipase D, Protein Kinase C, and Sodium-Calcium Exchanger in -Adrenoceptor-Mediated Negative Inotropy in Adult Mouse Ventricle

Journal of Pharmacological Sciences, 2003
The intracellular signalling pathway for a-adrenoceptor-mediated negative inotropy was studied pharmacologically in isolated adult mouse ventricle. The negative inotropy was inhibited by GF-109203X, a nonselective protein kinase C inhibitor.
Kazuhide Nishimaru, Yoshio Tanaka, Hikaru Tanaka, Koki Shigenobu   +3 more
doaj   +1 more source

Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice

Scientific Reports, 2017
Diabetic nephropathy (DN) is one of vascular complications of diabetes and is caused by abnormal protein kinase C activation as a result of increased diacylglycerol (DG) production in diabetic hyperglycaemia.
Daiki Hayashi, Keiko Yagi, Chihong Song, Shuji Ueda, Minoru Yamanoue, Matthew Topham, Toshinobu Suzaki, Naoaki Saito, Noriaki Emoto, Yasuhito Shirai   +9 more
doaj   +1 more source

Liganded peroxisome proliferator-activated receptors (PPARs) preserve nuclear histone deacetylase 5 levels in endothelin-treated Sprague-Dawley rat cardiac myocytes.

PLoS ONE, 2014
Ligand activation of peroxisome proliferator-activated receptors (PPARs) prevents cardiac myocyte hypertrophy, and we previously reported that diacylglycerol kinase zeta (DGKζ) is critically involved.
Haining Zhang, Zongjun Shao, Caroline P Alibin, Crystal Acosta, Hope D Anderson   +4 more
doaj   +1 more source

Diacylglycerol Kinase ζ Attenuates Doxorubicin‐Induced Cardiotoxicity Through p53 Degradation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Doxorubicin‐induced cardiotoxicity is still an important medical problem associated with a high mortality rate in cancer survivors. p53 plays a key role in doxorubicin‐induced cardiotoxicity.
Shingo Tachibana, Yoichiro Otaki, Tetsu Watanabe, Jun Goto, Haruki Ochi, Toshiaki Tanaka, Hiroe Ono, Ryuhei Yamaguchi, Junya Sato, Hiroki Takahashi, Takanori Arimoto, Kaoru Goto, Masafumi Watanabe   +12 more
doaj   +1 more source

Diacylglycerol kinases: A look into the future of immunotherapy

Advances in Biological Regulation
Cancer still represents the second leading cause of death right after cardiovascular diseases. According to the World Health Organization (WHO), cancer provoked around 10 million deaths in 2020, with lung and colon tumors accounting for the deadliest forms of cancer.
Miguel Martin-Salgado, Ane Ochoa-Echeverría, Isabel Mérida   +2 more
openaire   +3 more sources

Egr2 to the rescue: nanoparticles revitalize natural killer cells in the fight against cancer

The EMBO Journal
Reversal of tumor-induced natural killer (NK) cell dysfunction remains a major hurdle to overcome for the clinical success of immunotherapies based on NK cells targeting solid tumors.
Aline Pfefferle, Santosh Phuyal, Herman Netskar, Karl-Johan Malmberg   +3 more
doaj   +1 more source

Diacylglycerol kinase δ is required for skeletal muscle development and regeneration

FASEB BioAdvances
Diacylglycerol kinase δ (DGKδ) phosphorylates diacylglycerol to produce phosphatidic acid. Previously, we demonstrated that down‐regulation of DGKδ suppresses the myogenic differentiation of C2C12 myoblasts.
Hiromichi Sakai, Chiaki Murakami, Mayumi Takechi, Takeshi Urano, Fumio Sakane   +4 more
doaj   +1 more source

Expression, Purification, and Characterization of Human Diacylglycerol Kinase ζ

ACS Omega, 2019
Takumi Saito, Daisuke Takahashi, Fumio Sakane   +2 more
doaj   +1 more source

Diacylglycerol Kinase Alpha [PDF]

, 2020
openaire   +1 more source

Diacylglycerol Kinase Zeta [PDF]

, 2020
openaire   +1 more source