Results 161 to 170 of about 115,506 (337)

Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]

open access: yes, 2008
To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L.   +7 more
core   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck   +1 more
wiley   +1 more source

Seed-Specific Over-Expression of an Arabidopsis cDNA Encoding a Diacylglycerol Acyltransferase Enhances Seed Oil Content and Seed Weight [PDF]

open access: bronze, 2001
Colette Jako   +7 more
openalex   +1 more source

Associations between steatotic liver disease subtypes and incident diabetes in young Korean adults: A nationwide cohort study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims The impact of steatotic liver disease (SLD) subtypes on incident type 2 diabetes remains unclear. We investigated the association of metabolic dysfunction‐associated steatotic liver disease (MASLD), MetALD (MASLD with moderate alcohol consumption), and alcohol‐related liver disease (ALD) with incident type 2 diabetes in Korean adults aged
Goh Eun Chung   +6 more
wiley   +1 more source

Is AMP‐activated protein kinase activation a central mechanism of cardio‐metabolic outcomes after metabolic and bariatric surgery?

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity. It usually results in spectacular weight loss, associated with improvements of obesity‐associated comorbidities. The mechanisms underlying these benefits are not fully understood but could involve a postoperative activation of the enzyme 5′ AMP‐activated ...
Adrien Delcour, Nathalie Niederhoffer
wiley   +1 more source

Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans [PDF]

open access: yes, 2018
Finck, Brian N.   +7 more
core   +2 more sources

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

open access: yesEquine Veterinary Education, EarlyView.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell   +4 more
wiley   +1 more source

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