Results 151 to 160 of about 73,981 (291)
Diacylglycerol Signaling in Retinal Ganglion Cells
With impaired retinal ganglion cell (RGC) function and eventual RGC death, there is a heightened risk of experiencing glaucoma-induced blindness or other optic neuropathies.
Chaplot, Ishan +3 more
core +1 more source
Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou +5 more
wiley +1 more source
Dapagliflozin Alters Plasma Metabolome in Patients With Type 1 Diabetes During Ketosis
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Use of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 1 diabetes (T1D) is limited by increased risk of ketoacidosis. We aimed to determine metabolic pathways affected by SGLT2i treatment in adults with T1D during ketosis induced by insulin withdrawal.
Rosa Yang +6 more
wiley +1 more source
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Novel targets in headache: A narrative review
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra +5 more
wiley +1 more source
Journal of Diabetes Investigation, EarlyView.NPWT significantly increases the suppressed WTAP and m6A levels in DFU patients, correlating directly with better 4‐week healing outcomes. In vitro, negative pressure reverses high‐glucose‐induced WTAP downregulation, restoring the cell proliferation and migration necessary for wound repair.
Yutong Li +6 more
wiley +1 more source
Journal of Integrative Plant Biology, EarlyView.Engineering rice endosperm with modules for vitamin binding, lipid storage, and antioxidant protection enriched water‐ and fat‐soluble vitamins without compromising key agronomic traits and maintained vitamin higher levels after cooking, demonstrating its potential to improve crop nutrition.
Xingwei Cai +12 more
wiley +1 more source
Editorial: Diacylglycerol Kinase Signalling [PDF]
Frontiers in Cell and Developmental Biology, 2017 Isabel Merida +3 more
openaire +5 more sources
An OsSK12/13‐OsERF60‐OsHsfA2c module regulates heat stress tolerance in rice
Journal of Integrative Plant Biology, EarlyView.The heat‐induced GSK3‐like kinases OsSK12 and OsSK13 phosphorylate and stabilize the transcription factor OsERF60, which activates the expression of downstream genes including the heat shock factor gene OsHsfA2c. This regulatory module governs heat‐responsive gene induction, representing a mechanistic target for enhancing crop resilience under climate ...
Juan Gao +7 more
wiley +1 more source
Effects of dietary 1,3-diacylglycerol supplementation on growth performance and fat utilization in broilers fed palm kernel meal-based reduced-energy diets. [PDF]
Poult SciPark JH, Kim IH.
europepmc +1 more source