Results 191 to 200 of about 109,708 (338)

Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis

open access: yesBiological Research, 2002
Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous.
MARCIA M. WRIGHT   +1 more
doaj  

Differential Effects of Liver Regeneration on Aging‐Related Changes in Gene Expression and Metabolic Function

open access: yesAging Cell, EarlyView.
The age‐specific gene expression status of aged mouse hepatocytes is mostly resolved and rejuvenated when liver regeneration is completed; whereas the age‐specific intracellular metabolic status detected in the liver of aged mice is largely maintained and not rejuvenated even after liver regeneration is completed.
Ryo Murayama   +9 more
wiley   +1 more source

The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression

open access: yesAging Cell, EarlyView.
A multi‐omics analysis was performed to uncover the molecular landscape of human cardiac ageing. We report several insights for the first time: a decrease in proteins composing the structural machinery of the heart; a likely compensatory increase in energetic flux and redox reductive capacity; and an increase in lysosomal activity.
Cassandra Malecki   +20 more
wiley   +1 more source

Skin Lipid–Microbe Interplay Links Staphylococcus hominis to Barrier Control in Adult Atopic Dermatitis

open access: yesAllergy, EarlyView.
This study investigates mutual interaction of skin microbes and surface lipids in AD using the advanced method of shotgun lipidomics with ultra‐broad coverage of lipids and 16S amplicon sequencing of tape strips taken from lesional and non‐lesional AD and healthy controls.
Madhumita Bhattacharyya   +14 more
wiley   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

open access: yesBrain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li   +7 more
wiley   +1 more source

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