Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm
British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
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Cytotoxicity mechanism of heterologous expression of phospholipase D in <i>Escherichia coli</i>. [PDF]
Microbiol SpectrChen S +5 more
europepmc +1 more source
The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation
International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli +3 more
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Bovine viral diarrhea virus (BVDV) relies on cellular lipid droplet biogenesis and lipolysis to provide energy for viral replication. [PDF]
Vet ResXiong X, Liu Y, Zhu Y, Wang J, Yang G.
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Distinctive gene expression in the reduced first thoracic legs of a nymphalid butterfly
Insect Molecular Biology, Volume 35, Issue 5, Page 504-516, October 2026.Transcriptome analysis reveals that the small non‐walking front legs of a butterfly have distinct gene expression to the four walking legs. Reduced front legs express a gene with putative mechanosensory roles, a blue‐sensitive opsin and two homeobox genes.
Asia E. Hoile +2 more
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Diacylglycerol enantiomer selectivity of diacylglycerol acyltransferases highlights metabolic specialization in triacylglycerol synthesis across the tree of life. [PDF]
Biosci RepParchuri P +3 more
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Lipid Accumulation Promotes Tumorigenic Behaviour of Colorectal Cancer Cells
Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.ABSTRACT Obesity and hyperlipidemia are risk factors for the development and progression of different types of cancer including colorectal cancer (CRC). The underlying mechanisms are only incompletely understood. The aim of this study was to assess the impact of hyperlipidemic conditions on tumorigenic behaviour of CRC cells and the effect of obesity ...
Tatjana Itzenhäuser +7 more
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Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates
Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.An alkyne‐tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the Kennedy pathway, allowing CuAAC‐based visualization of PE and affinity capture of PE‐conjugated LC3, ubiquitin, and GPI‐anchored proteins.
Yuan‐Ting Cho +5 more
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Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice. [PDF]
FASEB JPan Q +6 more
europepmc +1 more source
New Phytologist, Volume 252, Issue 1, Page 222-240, October 2026.Proposed model for auxin–DGAT2 crosstalk regulating high‐temperature‐induced hypocotyl elongation. Summary Cell elongation is a fundamental process in plant growth and development, and it is significantly affected by temperature changes. While the signaling mechanisms driving high‐temperature‐induced cell elongation have been extensively studied, the ...
Mohinur Khamzaaliyeva +3 more
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