Results 81 to 90 of about 128,436 (385)

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]

, 1994
Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M, Cifone, MG, De Maria, R, Lanier, LL, Rippo, MR, Roncaioli, P, Santoni, A, Testi, R   +7 more
core   +2 more sources

MALMPS: A Machine Learning‐Based Metabolic Gene Prognostic Signature for Stratifying Clinical Outcomes and Molecular Heterogeneity in Stage II/III Colorectal Cancer

Advanced Science, EarlyView.
Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen, Ze Wang, Chenglong Sun, Yang Zhong, Yuan Liu, Yikun Li, Tongchao Zhang, Yuan Zhang, Xingyu Zhu, Leping Li, Feifei Teng, Ming Lu, Wei Chong   +12 more
wiley   +1 more source

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer reviewedPublisher ...
Barabas, Klaudia, Cameron, Gary, Harkany, Tibor, Keimpema, Erik, Mackie, Ken, Morozov, Yury M, Torii, Masaaki, Tortoriello, Giuseppe, Watanabe, Masahiko, Yanagawa, Yuchio   +9 more
core   +1 more source

A polarized Ca2+, diacylglycerol, and STIM1 signaling system regulates directed cell migration

Nature Cell Biology, 2014
Ca2+ signals control cell migration by regulating forward movement and cell adhesion. However, it is not well understood how Ca2+-regulatory proteins and second messengers are spatially organized in migrating cells.
Feng-Chiao Tsai, A. Seki, Heebum Yang, Arnold Hayer, Silvia Carrasco, S. Malmersjö, T. Meyer   +6 more
semanticscholar   +1 more source

1,3-Diacylglycerol and 1,2-Diacylglycerol Types of Multiacylglycerol in Stigma Lipids of Tobacco [PDF]

Agricultural and Biological Chemistry, 1986
The 1, 3-diacylglycerol and 1, 2-diacylglycerol types of multiacylglycerol were first isolated from the stigmas of Nicotiana tabacum (Bright Yellow). These multiacylglycerols were separated into more than five spots, such as tri-, tetra-, penta-, hexa- and heptaacylglycerol.
Toshiake Matsuzaki, Kubo Susumu, Akira Koiwai   +2 more
openaire   +3 more sources

Glucose‐Responsive PAGR1‐Regulated Skeletal Muscle Gene Program Controls Systemic Glucose Homeostasis and Hepatic Metabolism

Advanced Science, EarlyView.
The study reveals that PAXIP1‐associated glutamate‐rich protein 1 (PAGR1), a glucose‐responsive regulator in skeletal muscle, modulates systemic glucose homeostasis and hepatic metabolism. Muscle‐specific PAGR1 deletion enhances insulin signaling, promotes glucose transporter 4 (GLUT4) translocation, and protects against high‐fat‐diet‐induced insulin ...
Chenyun Ding, Yuhuan Jia, Lin Liu, Wen Wang, Danxia Zhou, Zheng Zhou, Likun Yang, Xinyi Chen, Di Chen, Yan Mao, Liwei Xiao, Cai‐Zhi Liu, Zhen‐Yu Du, Yujing Yin, Qiqi Guo, Zongchao Sun, Kai Ge, Tingting Fu, Hai‐Long Piao, Zhenji Gan   +19 more
wiley   +1 more source

Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver

Journal of Lipid Research, 2012
Intrahepatic lipid accumulation is extremely common in obese subjects and is associated with the development of insulin resistance and diabetes. Hepatic diacylglycerol and triacylglycerol synthesis predominantly occurs through acylation of glycerol-3 ...
Angela M. Hall, Kou Kou, Zhouji Chen, Terri A. Pietka, Mrudula Kumar, Kevin M. Korenblat, Kyuha Lee, Kay Ahn, Elisa Fabbrini, Samuel Klein, Bryan Goodwin, Brian N. Finck   +11 more
doaj   +1 more source

Ternary structure reveals mechanism of a membrane diacylglycerol kinase

Nature Communications, 2015
Diacylglycerol kinase catalyses the ATP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membrane of Escherichia coli. The small size of this integral membrane trimer, which has 121 residues per subunit, means that available ...
Dianfan Li, P. Stansfeld, M. Sansom, Aaron P. Keogh, L. Vogeley, N. Howe, J. Lyons, D. Aragão, P. Fromme, R. Fromme, S. Basu, I. Grotjohann, Christopher Kupitz, Kimberley N. Rendek, U. Weierstall, N. Zatsepin, V. Cherezov, Wei Liu, S. Bandaru, Niall J. English, C. Gati, A. Barty, O. Yefanov, H. Chapman, K. Diederichs, M. Messerschmidt, S. Boutet, Garth J. Williams, M. Marvin Seibert, M. Caffrey   +29 more
semanticscholar   +1 more source

Diacylglycerol-mediated insulin resistance [PDF]

Nature Medicine, 2010
Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to explain insulin resistance, and, most recently, inflammation associated with alterations in adipocytokines has become the prevailing hypothesis.
Gerald I. Shulman, Derek M. Erion
openaire   +3 more sources

Red Blood Cell Membrane Lipidomics: Potential Biomarkers Detecting Method for Plasma Volume Overload and Major Adverse Cardiovascular Events in Chronic Heart Failure Patients

Advanced Science, EarlyView.
A novel RBC indicator, ESI, is better than the traditional RBC indicators and is associated with CHF prevalence and in‐hospital death. RBC membrane lipidomics, Cer 18:0;O2/16:0, and LPE 18:0, are associated with plasma volume overload and MACE in CHF patients, but these plasma lipids could not.
Lin Zhang, Xiangqin Ou, Jingyi Lin, Xiaofei Luo, Jiashun Zhou, Xingyue Zhou, Peihua Zhao, Li Liu, Ziran Zhao, Ying Zhou, Guanwei Fan, Lifeng Han, Xiumei Gao   +12 more
wiley   +1 more source