Results 91 to 100 of about 881,635 (332)

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse

Molecular Biology of the Cell, 2011
Diacylglycerol (DAG) generation at the T cell immunological synapse (IS) determines the correct activation of antigen-specific immune responses. DAG kinases (DGKs) α and ζ act as negative regulators of DAG-mediated signals by catalyzing DAG conversion to phosphatidic acid (PA). Nonetheless, the specific input of each enzyme and their spatial regulation
Juan Pablo Albar, Esther Rincón, Isabel Mérida, Antonia Ávila-Flores, María Angeles Cobos, María Almena, Pedro Torres-Ayuso, Severine Gharbi   +7 more
openaire   +3 more sources

Heart failure and obesity: Translational approaches and therapeutic perspectives. A scientific statement of the Heart Failure Association of the ESC

European Journal of Heart Failure, EarlyView.
Abstract Obesity and heart failure (HF) represent two growing pandemics. In the general population, obesity affects one in eight adults and is linked with an increased risk for HF. Obesity is even more common in patients with HF, where it complicates the diagnosis of HF and is linked with worse symptoms and impaired exercise capacity. Over the past few
Gianluigi Savarese, Gabriele G. Schiattarella, Felix Lindberg, Markus S. Anker, Antoni Bayes‐Genis, Magnus Bäck, Frieder Braunschweig, Chiara Bucciarelli‐Ducci, Javed Butler, Antonio Cannata, Federico Capone, Ovidiu Chioncel, Emilia D'Elia, Arantxa González, Gerasimos Filippatos, Nicolas Girerd, Jean‐Sébastien Hulot, Carolyn S.P. Lam, Lars H. Lund, Christoph Maack, Brenda Moura, Mark C. Petrie, Massimo Piepoli, Abdullah Shehab, Mehmet B. Yilmaz, Peter Seferovic, Carlo G. Tocchetti, Giuseppe M.C. Rosano, Marco Metra   +28 more
wiley   +1 more source

Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration

Scientific Reports
Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to generate phosphatidic acid, which plays important roles in intracellular signal transduction. DGKα is reportedly associated with progression of tumors, including hepatocellular carcinomas, but
Hiroki Nakamoto, Shunsuke Shichi, Chisato Shirakawa, Takuto Suzuki, Hidemitsu Kitamura, Akinobu Taketomi   +5 more
doaj   +1 more source

Role of protein kinase C in inhibition of renin release caused by vasoconstrictors [PDF]

, 1986
It was the aim of the present study to get insight into some of the intracellular mechanisms by which the vasoconstrictor hormones angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine (NE) inhibit renin release from renal ...
Bauer, C., Bührle, C., Hackenthal, E., Hutter, A., Kurtz, Armin, Nobiling, R., Pfeilschifter, J., Taugner, R.   +7 more
core   +1 more source

The Diacylglycerol Kinase α/Atypical PKC/β1 Integrin Pathway in SDF-1α Mammary Carcinoma Invasiveness

PLoS ONE, 2014
Diacylglycerol kinase α (DGKα), by phosphorylating diacylglycerol into phosphatidic acid, provides a key signal driving cell migration and matrix invasion.
E. Rainero, Cristina Cianflone, P. Porporato, F. Chianale, Valeria Malacarne, Valentina Bettio, E. Ruffo, Michele Ferrara, Fabio Benecchia, D. Capello, W. Paster, Irene Locatelli, A. Bertoni, N. Filigheddu, F. Sinigaglia, J. Norman, G. Baldanzi, A. Graziani   +17 more
semanticscholar   +1 more source

The Ligand Binding Landscape of Diacylglycerol Kinases [PDF]

Cell Chemical Biology, 2017
Diacylglycerol kinases (DGKs) are integral components of signal transduction cascades that regulate cell biology through ATP-dependent phosphorylation of the lipid messenger diacylglycerol. Methods for direct evaluation of DGK activity in native biological systems are lacking and needed to study isoform-specific functions of these multidomain lipid ...
Thurl E. Harris, Ku-Lung Hsu, Sean T. Campbell, Benjamin Purow, Caroline E. Franks   +4 more
openaire   +3 more sources

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

Lipids in Health and Disease, 2020
Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes.
Katarzyna Kolczynska, Angel Loza-Valdes, Izabela Hawro, Grzegorz Sumara   +3 more
doaj   +1 more source

Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFκB activity in vertebrate B-cells [PDF]

, 2007
To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A ...
Andrew M. Scharenberg, Arnold, Chiu, Dequiedt, Doppler, Doreen A. Cantrell, Ferns, Genot, Guha, Iglesias, Jackson, Marklund, Matthews, Matthews, Matthews, Matthews, Matthews, Mihailovic, Nishikawa, Parra, Ping Liu, Rey, Rey, Rey, Sharon A. Matthews, Shinohara, Sinnett-Smith, Sinnett-Smith, Sommer, Song, Stokoe, Storz, Storz, Storz, Storz, Storz, Sturany, Trauzold, Vega, Waldron, Wang, Wang, Wong, Wong, Wood, Zhukova   +45 more
core   +3 more sources

Diacylglycerol Kinase α Regulates Tubular Recycling Endosome Biogenesis and Major Histocompatibility Complex Class I Recycling*

Journal of Biological Chemistry, 2014
Background: Major histocompatibility complex class I (MHC I) trafficking is crucial for antigen presentation. Results: Diacylglycerol kinase α (DGKα) depletion interferes with tubular recycling endosome (TRE) biogenesis and delays MHC I recycling to the ...
Shuwei Xie, Naava Naslavsky, S. Caplan
semanticscholar   +1 more source

Pyriproxyfen Disrupts the Ongoing Spermatogenesis Wave in Danio rerio Potentially Mediated by Voltage‐Dependent Calcium Channels and Protein Kinase C

Journal of Applied Toxicology, EarlyView.
ABSTRACT Pyriproxyfen (PPX) is an analog of the juvenile hormone from insects. Following our previous studies, for the ex vivo short‐term effect, we chose 10−9 M pyriproxyfen to analyze the morphology of spermatogenesis wave cells. In silico docking and ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) studies were carried out to ...
Bruna Antunes Zaniboni, Vanessa Staldoni de Oliveira, Gabriel Adan Araujo Leite, Valdelúcia Maria Alves de Souza Grinevicius, Rozangela Curi Pedrosa, Fátima Regina Mena Barreto Silva   +5 more
wiley   +1 more source