Results 101 to 110 of about 916,035 (361)
PLoS ONE, 2014 Diacylglycerol kinase α (DGKα), by phosphorylating diacylglycerol into phosphatidic acid, provides a key signal driving cell migration and matrix invasion.
E. Rainero +17 more
semanticscholar +1 more source
STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. [PDF]
, 2011 Clonal deletion of autoreactive B cells is crucial for the prevention of autoimmunity, but the signaling mechanisms that regulate this checkpoint remain undefined. Here we characterize a previously unrecognized Ca(2+)-driven pathway for activation of the
Depeille, Philippe +7 more
core
European Journal of Heart Failure, EarlyView.Abstract Obesity and heart failure (HF) represent two growing pandemics. In the general population, obesity affects one in eight adults and is linked with an increased risk for HF. Obesity is even more common in patients with HF, where it complicates the diagnosis of HF and is linked with worse symptoms and impaired exercise capacity. Over the past few
Gianluigi Savarese +28 more
wiley +1 more source
Journal of Lipid Research, 2001 The diacylglycerol (DAG) signal generated from membrane phospholipids by hormone-activated phospholipases is attenuated by mechanisms that include lipolysis or phospholipid resynthesis.
R. Ariel Igal +3 more
doaj
Lipids in Health and Disease, 2020 Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes.
Katarzyna Kolczynska +3 more
doaj +1 more source
Journal of Biological Chemistry, 2014 Background: Major histocompatibility complex class I (MHC I) trafficking is crucial for antigen presentation. Results: Diacylglycerol kinase α (DGKα) depletion interferes with tubular recycling endosome (TRE) biogenesis and delays MHC I recycling to the ...
Shuwei Xie, Naava Naslavsky, S. Caplan
semanticscholar +1 more source
Role of protein kinase C in inhibition of renin release caused by vasoconstrictors [PDF]
, 1986 It was the aim of the present study to get insight into some of the intracellular mechanisms by which the vasoconstrictor hormones angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine (NE) inhibit renin release from renal ...
Bauer, C. +7 more
core +1 more source
REGULATION OF DIACYLGLYCEROL KINASE THETA
The FASEB Journal, 2010 Diacylglycerol (DAG) and phosphatidic acid are important signaling molecules involved in numerous signaling pathways. The diacylglycerol kinases (DGKs) are particularly poised to regulate the cellular levels of these two lipids. Although interest in these enzymes is increasing, information regarding their regulation at a molecular level is scarce ...
Becky Tu-Sekine, Daniel M. Raben
openaire +1 more source
Association of diacylglycerol kinase ζ with protein kinase C α [PDF]
The Journal of Cell Biology, 2003 Activation of PKC depends on the availability of DAG, a signaling lipid that is tightly and dynamically regulated. DAG kinase (DGK) terminates DAG signaling by converting it to phosphatidic acid. Here, we demonstrate that DGKζ inhibits PKCα activity and that DGK activity is required for this inhibition.
Bai Luo +5 more
openaire +3 more sources
Light Activation of the Phosphoinositide Cycle in Intrinsically Photosensitive Chicken Retinal Ganglion Cells [PDF]
, 2010 Purpose: In vertebrates, intrinsically photosensitive retinal ganglion cells (ipRGCs) acting as nonvisual photoreceptors transmit environmental illumination information to the brain, regulating diverse non–image-forming tasks.
Contin, Maria Ana +5 more
core +1 more source