Results 101 to 110 of about 73,225 (285)

Diacylglycerol kinase β promotes dendritic outgrowth and spine maturation in developing hippocampal neurons

BMC Neuroscience, 2009
Background Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol to phosphatidic acid and comprises multiple isozymes of distinct properties.
Otani Koichi, Watanabe Masahiko, Hozumi Yasukazu, Goto Kaoru   +3 more
doaj   +1 more source

The Inositol- 1,4,5=Trisphosphate System Is Involved in Rapid Effects of Aldosterone in Human Mononuclear Leukocytes [PDF]

, 1993
There is increasing evidence for rapid steroid action on electrolyte transport in human mononuclear leukocytes (HML). In HML, aldosterone stimulates the Na+/H+ antiporter within a few minutes. Because a variety of hormones and growth factors activate the
Aktas, Janet, Christ, Michael, Eisen, Christoph, Theisen, Karl, Wehling, Martin   +4 more
core   +1 more source

An ecological framework for microbial metabolites in the ocean ecosystem

Limnology and Oceanography Letters, EarlyView.
Abstract The ocean microbe‐metabolite network involves thousands of individual metabolites that encompass a breadth of chemical diversity and biological functions. These microbial metabolites mediate biogeochemical cycles, facilitate ecological relationships, and impact ecosystem health. While analytical advancements have begun to illuminate such roles,
Bryndan P. Durham, Winifred M. Johnson, Catherine C. Bannon, Erin M. Bertrand, Anitra E. Ingalls, Bethanie R. Edwards, Amy Apprill, Angela K. Boysen, Randelle M. Bundy, Huan Chen, Frank X. Ferrer‐González, Cara Fiore, Katherine R. Heal, Constanze Kuhlisch, Shuting Liu, Kaijun Lu, Laurel E. Meke, Sammy Pontrelli, Prabavathy Vaiyapuri Ramalingam, Alicia M. Reigel, Joshua S. Sacks, Jeremy E. Schreier, Jegan Sekar, Mario Uchimiya, Elizabeth B. Kujawinski   +24 more
wiley   +1 more source

Immune evasion of the CD1d/NKT cell axis [PDF]

, 2018
Many reviews on the CD1d/NKT cell axis focus on the ability of CD1d-restricted NKT cells to serve as effector cells in a variety of disorders, be they infectious diseases, cancer or autoimmunity.
Brutkiewicz, Randy R., Liu, Jianyun, Yunes-Medina, Laura   +2 more
core   +1 more source

The Dual Role of Exosomes in the Tumor Microenvironment: From Pro‐Tumorigenic Signaling to Immune Modulation

Med Research, EarlyView.
Tumor‐derived exosomes influence proliferation, invasion, angiogenesis, metabolic adaptation, and resistance to therapy. They also shape the immune landscape by modulating antigen presentation, suppressing cytotoxic lymphocyte activity, and promoting the expansion of immunosuppressive cell populations. Although frequently associated with immune evasion,
Jiale Li, Jun Peng, Jiachong Wang, Zigui Chen   +3 more
wiley   +1 more source

Differential regulation of diacylglycerol kinase isoform in human failing hearts

Journal of Cardiothoracic Surgery, 2011
Evidence from several studies indicates the importance of Gαq protein-coupled receptor (GPCR) signaling pathway, which includes diacylglycerol (DAG), and protein kinase C, in the development of heart failure.
Sadahiro Mitsuaki, Kitahara Tatsuro, Sasaki Toshiki, Suzuki Satoshi, Toyama Shuji, Shishido Tetsuro, Bilim Olga, Takeishi Yasuchika, Kubota Isao   +8 more
doaj   +1 more source

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko, Kambe, Yuki, Taniura, Hideo, Yoneda, Yukio   +3 more
core  

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]

, 2014
Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre, Antonescu, Bain, Boppart, Cancello, Cao, Carlson, Caroline P. Wheeler-Jones, Cazzolli, Chavez, Cleasby, Coll, Corraliza, de Alvaro, De Paepe, Devaraj, Diamond-Stanic, Dimopoulos, Elgazar-Carmon, Festa, Fink, Fujishiro, Gao, Griffin, Haversen, Hemi, Hevener, Hirabara, Hirosumi, Hoehn, Hommelberg, Hotamisligil, Hotamisligil, Hwang, Kadotani, Karten, Kewalramani, Kuma, Lee, Lee, Liang, Lumeng, Lumeng, Maekawa, Mark E. Cleasby, McCall, Nguyen, Nicola A. Talbot, Patel, Pillon, Pinnick, Plomgaard, Polkinghorne, Prieur, Samokhvalov, Schilling, Sell, Shi, Solinas, Storlien, Suganami, Tardif, Thong, Turner, Uysal, Varma, Weisberg, Yuan   +67 more
core   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, EarlyView.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

A Mediterranean Diet‐Based Food Mix Ameliorates Diabetes‐ and Obesity‐Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming

Molecular Nutrition &Food Research, EarlyView.
Metabolic syndrome (MetS)‐related conditions are key factors in liver damage. A Mediterranean lifestyle shows promise in managing MetS, though its mechanisms remain unclear. This study tested a lab‐designed food mix mimicking the 1960s Mediterranean Diet (MD) on obese and diabetic mice; it prevented hyperlipidemia and reduced oxidative liver damage ...
Giovanna Mercurio, Antonia Giacco, Antonio Dario Troise, Moira Ledbetter, Sabrina De Pascale, Nicla Scopigno, Michela Vigliotti, Matteo Mazzola, Giuseppe Riccio, Andrea Scaloni, Maria Moreno, Alberto Fiore, Federica Cioffi, Elena Silvestri   +13 more
wiley   +1 more source