Results 81 to 90 of about 916,035 (361)

Characterization of AtDGK2 in relation to Contact Sites [PDF]

, 2019
Contact Sites are conserved cellular regions where two membranes of different organelles are very close but not merged. Contact sites between the endoplasmic reticulum (ER) and the plasma membrane (ER-PM CS) play important roles in metabolic functions ...
Botella-Mesa, Miguel Angel, García-Hernández, Selene, Ruiz-López, Noemi   +2 more
core  

A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma

Advanced Science, EarlyView.
The current study has profiled the landscape of active enhancers in ccRCC and identified FABP5 as an oncogene. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity. The study has discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC ...
Zhou Ye, Qi‐Xin Hu, Ming‐Liang Wei, Ji‐Dong Chen, Jia Shi, Ning‐Rong Yang, Lu Jiang, Jian Chen, Zhi‐Yuan Chen, Wei‐Min Yu, Yu Xiao, Kai‐Yu Qian, Zilin Xu, Zhong Wang, Wen‐Lu Qi, Xin‐Yi Xiao, Yu‐Yu Duan, Yong Xiao, Lian‐Yun Li, Lin‐Gao Ju, Ming‐Kai Chen, Min Wu   +21 more
wiley   +1 more source

Ternary structure reveals mechanism of a membrane diacylglycerol kinase

Nature Communications, 2015
Diacylglycerol kinase catalyses the ATP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membrane of Escherichia coli. The small size of this integral membrane trimer, which has 121 residues per subunit, means that available ...
Dianfan Li, P. Stansfeld, M. Sansom, Aaron P. Keogh, L. Vogeley, N. Howe, J. Lyons, D. Aragão, P. Fromme, R. Fromme, S. Basu, I. Grotjohann, Christopher Kupitz, Kimberley N. Rendek, U. Weierstall, N. Zatsepin, V. Cherezov, Wei Liu, S. Bandaru, Niall J. English, C. Gati, A. Barty, O. Yefanov, H. Chapman, K. Diederichs, M. Messerschmidt, S. Boutet, Garth J. Williams, M. Marvin Seibert, M. Caffrey   +29 more
semanticscholar   +1 more source

Diacylglycerol kinases in the regulation of dendritic spines [PDF]

Journal of Neurochemistry, 2010
J. Neurochem. (2010) 112, 577–587.AbstractDiacylglycerol (DAG) is an important lipid‐signaling molecule that binds and activates various downstream effectors. Tight control over the production and removal of DAG is important in maintaining the dynamic responses of the DAG signaling system to a changing environment.
Kim, K, Yang, J, Kim, E Kim, Eunjoon
openaire   +4 more sources

A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long-Term Potentiation [PDF]

, 2006
The induction of late long-term potentiation (L-LTP) involves complex interactions among second messenger cascades. To gain insights into these interactions, a mathematical model was developed for L-LTP induction in the CA1 region of the hippocampus. The differential equation-based model represents actions of protein kinase A (PKA), MAP kinase (MAPK ...
arxiv   +1 more source

TRIB3 suppresses milk fatty acids metabolism by inhibiting p‐AKT/PPARG signaling in goat mammary epithelial cells

Animal Research and One Health, EarlyView.
In this study, it revealed that TRIB3 could mediate the transcriptional activity of PPARG, inhibit the phosphorylation of akt, and reduce the expression of lipid metabolism‐related genes, thus inhibiting TAG synthesis and affecting fatty acid composition.
Xinglong Gong, Tan Pan, Tiantian Xiong, Yifan Zhu, Juan J. Loor, Chengming Han, Yifan Li, Huan Lei, Jun Luo, Cong Li   +9 more
wiley   +1 more source

Identification of Synaptic DGKθ Interactors That Stimulate DGKθ Activity

Frontiers in Synaptic Neuroscience, 2022
Lipids and their metabolic enzymes are a critical point of regulation for the membrane curvature required to induce membrane fusion during synaptic vesicle recycling.
Casey N. Barber, Casey N. Barber, Hana L. Goldschmidt, Qianqian Ma, Lauren R. Devine, Robert N. Cole, Richard L. Huganir, Daniel M. Raben   +7 more
doaj   +1 more source

Complement mutations in diacylglycerol kinase-ε-associated atypical hemolytic uremic syndrome.

American Society of Nephrology. Clinical Journal, 2014
BACKGROUND AND OBJECTIVES Atypical hemolytic uremic syndrome is characterized by vascular endothelial damage caused by complement dysregulation. Consistently, complement inhibition therapies are highly effective in most patients with atypical hemolytic ...
Daniel Sánchez Chinchilla, Sheila Pinto, B. Hoppe, M. Adragna, Laura López, M. J. Justa Roldán, A. Peña, M. López Trascasa, P. Sánchez-Corral, S. Rodríguez de Córdoba   +9 more
semanticscholar   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis

Biological Research, 2002
Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous.
MARCIA M. WRIGHT, CHRISTOPHER R. MCMASTER   +1 more
doaj