Results 121 to 130 of about 533,448 (310)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Exosomal miR-320e as a Novel Potential Biomarker for Cerebral Small Vessel Disease
International Journal of General Medicine, 2023 Ke-Jin Gao,1 Rui-Hua Yin,1 Yuan Wang,1 Zheng Wang,1 Ai-Jun Ma1,2 1Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, People’s Republic of China; 2Institute of Cerebrovascular, The Affiliated Hospital of ...
Gao KJ, Yin RH, Wang Y, Wang Z, Ma AJ
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Exploration into Plasma Hsa_circ_0052184 as a New Biomarker of Colorectal Cancer Prognosis
Pharmacogenomics and Personalized Medicine, 2023 Enqi Zheng, Deshuang Xiao Hernia Vascular Surgery, The First People’s Hospital of Wenling, Wenling, Zhejiang, People’s Republic of ChinaCorrespondence: Deshuang Xiao, Hernia Vascular Surgery, The First People’s Hospital of Wenling, No. 333 Chuan’an South
Zheng E, Xiao D
doaj
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Diagnostic biomarkers in mastocytosis
Salud, Ciencia y TecnologíaIntroduction: mastocytosis is a rare disease triggered by the KIT D816V mutation that increases the proliferation and survival of mast cells in several organs. Mast cells have crucial receptors such as KIT, TLR, complement (C5aR, C3aR), MHCI, MHCII, MRGPRX, and FcεRI that allow them to activate and degranulate in innate and adaptive immune responses ...
Viviana Estephania Núñez Reyes +1 more
openaire +1 more source