Results 1 to 10 of about 350,313 (397)
First in human phase 1 study of DT2216, a selective BCL-xL degrader, in patients with relapsed/refractory solid malignancies [PDF]
Journal of Hematology & OncologyBackground Small molecule inhibition of BCL-XL with navitoclax resulted in on-target dose-limiting thrombocytopenia. DT2216 was more effective than navitoclax and reduced platelet toxicity in preclinical models by selectively degrading BCL-XL via the VHL
Daruka Mahadevan +14 more
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Biomimetics with Trade-Offs [PDF]
Biomimetics, 2023 Our knowledge of physics and chemistry is relatively well defined. Results from that knowledge are predictable as, largely, are those of their technical offspring such as electrical, chemical, mechanical and civil engineering.
Julian Vincent
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Dialectics and dilemmas arising from Covid-19 immunity testing: presenting a workforce management paradox [PDF]
Journal of Work-Applied Management, 2021 Purpose – Covid-19 has caused many businesses to rethink their short- and potentially long-term workforce operations. The use of lateral flow serology can provide a clinically convenient approach for the assessment of prior infection with Covid-19 ...
Steven Davies +3 more
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Determining and Grounding: The Twofold Function of the Transcendental Dialectic
Open Philosophy, 2022 For a long time, the transcendental dialectic was not at the center of Kant scholarship but was often treated simply as Kant’s reckoning with contemporary metaphysics.
Bunte Martin
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Fede, ragione e il principio di non-contraddizione in Pier Damiani
Noctua, 2021 In literature Peter Damian has been often presented as an anti-dialectic thinker. Over time this statement has been subjected to careful historiographical revision.
Fabrizio Amerini
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Наукові записки НаУКМА: Філософія та релігієзнавство, 2021 The present paper is a practical supplement to an earlier theoretical work by the author, published in a preceding issue, on methodological foundations of the European philosophizing in the aspect of sophical synthesis.
Yuriy Svatko
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The dialectic of democracy: modernization, emancipation and the great regression
Democratization, 2020 In some of the most established and supposedly immutable liberal democracies, diverse social groups are losing confidence not only in established democratic institutions, but in the idea of liberal representative democracy itself. Meanwhile, an illiberal
Ingolfur Blühdorn
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Dialectic and Refutation in Plato. On the Role of Refutation in the Search for Truth
Archai: Revista de Estudos sobre as Origens do Pensamento Ocidental, 2022 While refutation is usually related to Plato's early, Socratic, dialogues, this paper is aimed at exploring the link between refutation and dialectic in some of his middle and late dialogues.
Graciela Marcos
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Dialectic and Refutation in Plato and Aristotle
Archai: Revista de Estudos sobre as Origens do Pensamento Ocidental, 2022 The papers in this dossier were written within the framework of two research projects on the refutation strategies of radical adversaries in Plato’s and Aristotle’s writings.
Pilar Spangenberg
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Trans/Form/Ação, 2007 Este trabalho objetiva caracterizar a lógica e a dialética, conforme a Enéada I, 3 [20] 4-5. Para Plotino, a lógica consiste em um conjunto de procedimentos que trata de proposições e silogismos.
Loraine Oliveira
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