Personalized Medicine: Unraveling the Potential of Diamine Oxidase Deficiency [PDF]
Journal of Clinical MedicineThe Special Issue Diamine Oxidase Deficiency: Prevalence, consequences, and solutions brings together a series of groundbreaking studies that explore the role of four single-nucleotide polymorphisms (SNPs) (rs10156191, rs1049742, rs1049793, and rs2052129) of the Diamine Oxidase (DAO) across various medical conditions, with a special focus on its ...
Hilario Blasco-Fontecilla
exaly +5 more sources
Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain
Biomedicines, 2023 Diamine oxidase (DAO) is an enzyme that metabolizes intestinal histamine. Single nucleotide polymorphisms (SNPs) of the Amine Oxidase Copper Containing 1 (AOC1) gene can lead to low enzymatic activity or functionality in histamine metabolism.
Gülşah Okutan +8 more
doaj +6 more sources
Lower Urinary Tract Symptoms (LUTS) as a New Clinical Presentation of Histamine Intolerance: A Prevalence Study of Genetic Diamine Oxidase Deficiency [PDF]
Journal of Clinical Medicine, 2023 Lower urinary tract symptoms (LUTS) are highly prevalent, and their treatment is mainly focused on the control of symptoms. Histamine intolerance (HIT) has been related to a variety of systemic symptoms. DAO deficiency has been identified as a significant factor contributing to histamine intolerance (HIT). Preclinical evidence indicates the involvement
Ponce Diaz-Reixa J +2 more
exaly +5 more sources
A case series of diamine oxidase deficiency misdiagnosed as anxiety or panic attacks in patients with tachycardia [PDF]
Indian Journal of PsychiatryBackground: Diamine oxidase (DAO) deficiency, a key marker of histamine intolerance (HIT), often mimics anxiety or panic disorders, leading to a misdiagnoses and delayed treatment.
Ilkay Keskinel
doaj +4 more sources
Improvement of Histamine Intolerance Symptoms in Pregnant Women with Diamine Oxidase Deficiency: An Exploratory Study [PDF]
Journal of Clinical MedicineBackground/Objectives: Diamine oxidase (DAO) deficiency can lead to excessive histamine absorption at the intestinal level, triggering symptoms that affect the gastrointestinal, neurological, dermatological, respiratory, circulatory, and musculoskeletal systems. This condition, known as histamine intolerance, is more prevalent in women. While serum DAO
Mariluz Latorre-Moratalla +2 more
exaly +5 more sources
The Prevalence of Diamine Oxidase Polymorphisms and Their Association with Histamine Intolerance Symptomatology in the Mexican Population [PDF]
BiomedicinesExogenous histamine obtained from the intake of histamine-rich food is mainly metabolized by the diamine oxidase enzyme (DAO). Histamine intolerance (HIT) is an alteration mainly caused by DAO deficiency, which is commonly associated with ...
Pamela Aguilar-Rodea +8 more
doaj +4 more sources
Histamine intolerance caused by Diamine Oxidase (DAO) deficiency – case report
Journal of Pre-Clinical and Clinical Research, 2022 Histamine is a biogenic amine, which occurs naturally in the human body. Histamine can be metabolised with Diamine Oxidase (DAO) Enzyme. It is estimated that in 1% of people, as a result of an imbalance between the supply and degradation of histamine, a ...
Aleksandra Iwona Zimna +5 more
doaj +4 more sources
Is histamine intolerance a treatable subtype of fibromyalgia? evidence and clinical implications—narrative review [PDF]
Frontiers in Pain ResearchBackgroundFibromyalgia affects 2%–8% of the global population with suboptimal treatment outcomes. Emerging evidence suggests histamine intolerance, mediated by diamine oxidase (DAO) deficiency, may contribute to fibromyalgia pathophysiology in specific ...
João Protásio Netto +6 more
doaj +2 more sources
Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial [PDF]
Clinical Nutrition, 2019 Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by a deficiency in the enzyme diamine oxidase (DAO). Among histamine related symptoms, headache is one of the most recorded. Current clinical strategies for the treatment of the symptomatology related to this disorder
M Carmen Vidal-Carou +2 more
exaly +4 more sources
Mast cell mediators in hereditary angioedema [PDF]
Orphanet Journal of Rare DiseasesBackground Bradykinin-mediated hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH) is often hard to differentiate from mast cell (MC) mediated diseases.
Hanga Réka Horváth +4 more
doaj +2 more sources