Results 51 to 60 of about 1,117 (151)

Method development and validation of an analytical quality by design ultrafast liquid chromatographic method for the determination of bedaquiline from pharmaceutical bulk and nanoemulsions

Biomedical Chromatography, Volume 38, Issue 12, December 2024.
Abstract Bedaquiline (BDQ) is a drug used to treat multidrug‐resistant tuberculosis (MDR‐TB). It exhibits exposure‐dependent efficacy in eliminating Mycobacterium tuberculosis (Mtb). An easy, efficient and precise reverse‐phase ultrafast liquid chromatography (RP‐UFLC) method was developed to validate the free base of the antitubercular medication BDQ.
Taiwo Oreoluwa Ajayi, Madan Sai Poka, Bwalya Angel Witika   +2 more
wiley   +1 more source

TBAJ-587, a novel diarylquinoline, is active against Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy
ABSTRACT Nontuberculous mycobacteria (NTM) infections are extremely difficult to treat due to a natural resistance to many antimicrobials. TBAJ-587 is a novel diarylquinoline, which shows higher anti-tuberculosis activity, lower lipophilicity, and weaker inhibition of hERG channels than bedaquiline ...
Junsheng Fan, Zhili Tan, Siyuan He, Anqi Li, Yaping Jia, Juan Li, Zhemin Zhang, Bing Li, Haiqing Chu   +8 more
openaire   +2 more sources

Exploring the Chemical Space of Mycobacterial Oxidative Phosphorylation Inhibitors Using Molecular Modeling

ChemMedChem, Volume 19, Issue 22, November 18, 2024.
Intracellular pathogens are exceedingly clinically challenging, including pathogenic mycobacteria. Many global efforts are currently in action to battle these notorious disease agents. This review provides an overview of mycobacteria, along with their associated diseases, pathogenesis, and exploitable respiratory vulnerabilities to supplement ...
Islam K. Matar, Zhongmin Dong, Chérif F. Matta   +2 more
wiley   +1 more source

Clinical efficacy and computed tomography diagnostic value of bedaquiline‐containing regimens in the treatment of drug‐resistant pulmonary tuberculosis

iLABMED, Volume 2, Issue 3, Page 149-156, September 2024.
This paper emphasizes the key role of Bedazoline Tablets in the treatment of drug‐resistant tuberculosis in turning negative sputum culture and improving absorption of chest CT lesions. It is helpful to improve the cure rate of drug‐resistant tuberculosis patients.
Saiduo Liu, Xinchun Ye, Fang Cheng, Kaijia Wu, Jiandan Yu, Hongye Ning, Jichan Shi, Hongzhou Lu, Wei Chen   +8 more
wiley   +1 more source

The Diarylquinoline R207910 Is Bactericidal against Mycobacterium leprae in Mice at Low Dose and Administered Intermittently [PDF]

Antimicrobial Agents and Chemotherapy, 2009
ABSTRACT The diarylquinoline R207910 is profoundly bactericidal in a murine model of tuberculosis. Previously, R207910 was also found to be bactericidal for Mycobacterium leprae -infected mice during lag phase.
Gelber, Robert, Andries, Koen, Paredes, Rose Maria D., Andaya, Cora Evelyn S., Burgos, Jasmin   +4 more
openaire   +3 more sources

Subcutaneous infection caused by Mycobacterium abscessus following botulinum toxin injections: A case report and literature review

Journal of Cosmetic Dermatology, Volume 23, Issue 5, Page 1527-1532, May 2024.
Abstract Background The rapid development of cosmetic injections has led to an increased incidence of nontuberculous mycobacterial (NTM) infection. Patients and Methods Here, we presented a case of cutaneous Mycobacterium abscessus infection subsequent to botulinum toxin injection for treating masseter hypertrophy, and reviewed the literature on skin ...
Yanting Ou, Dandan Liu, Jun Feng, Xiangwen Xu, Tingyin Lin, Yihan Zhang, Lin Luo, Mengfan Wu, Yongyan Cui   +8 more
wiley   +1 more source

What is the role of microbial biotechnology and genetic engineering in medicine?

MicrobiologyOpen, Volume 13, Issue 2, April 2024.
Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley   +1 more source

Safety, pharmacokinetics, and food effect of sudapyridine (WX‐081), a novel anti‐tuberculosis candidate in healthy Chinese subjects

Clinical and Translational Science, Volume 17, Issue 2, February 2024.
Abstract This study aimed to assess the safety, pharmacokinetics, and food impact on sudapyridine (WX‐081), a novel drug designed to inhibit mycobacterium ATP synthase, with clinical applications for drug‐resistant tuberculosis (TB) treatment. The research comprised two arms: a single ascending dose (SAD) arm (30 to 600 mg, N = 52) and a multiple ...
Chengyin Yu, Hongjie Qian, Qingqing Wu, Yang Zou, Qicheng Ding, Yuting Cai, Liyu Liang, Juncai Xu, Lei Li, Bin Zan, Yongguo Li, Yun Liu   +11 more
wiley   +1 more source

Diarylquinoline TMC207 as potential new therapy for multidrug-resistant tuberculosis [PDF]

Thorax, 2009
TMC207 is an investigational diarylquinoline which inhibits mycobacterial ATP synthase in drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro. It is bactericidal to dormant tubercle bacilli, therefore offering a new mechanism for the treatment of multidrug-resistant tuberculosis.
openaire   +1 more source

Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention

MedComm, Volume 5, Issue 1, January 2024.
Currently, controlling the source of infection, interrupting transmission pathways, and protecting susceptible populations are key measures in tackling MTB infection. However, preventative, diagnostic, and therapeutic interventions for TB are also important in reducing the burden of the disease. First, in terms of preventing MTB infection, the Bacillus
Li Zhuang, Ling Yang, Linsheng Li, Zhaoyang Ye, Wenping Gong   +4 more
wiley   +1 more source