Results 201 to 210 of about 20,067 (277)

Reenvisioning the De Mayo Reaction: A Boron‐Enabled Cycloaddition Approach

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
An oxa‐boracycle conformational lock strategy enables photocatalytic [2+2] cycloaddition to afford densely substituted cyclobutylboronates. The conformational constraint suppresses triplet relaxation and promotes productive bimolecular reactivity.
Neetu Sharma, Yanyao Liu, Partha Sarathi Hazra, Evan B. Piper, Ryan Van Hoveln, Michael Kevin Brown   +5 more
wiley   +2 more sources

A Multicatalytic Cascade for the Stereoselective Synthesis of 1,4-Chiral Nitro Alcohols. [PDF]

Org Lett
Ascaso-Alegre C, Linacero-Gracia Á, Ferreira P, Herrera RP, Mangas-Sánchez J.   +4 more
europepmc   +1 more source

Synthetic Ligands of Myeloid C‐Type Lectin Receptors

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley   +1 more source

Advances in Analysis of Therapeutic Oligonucleotides with Chromatography Coupled to Mass Spectrometry. [PDF]

Anal Chem
Al Bardawil S, Barthélémy P, Ferey L.
europepmc   +1 more source

Fluorinated Aminopiperidones as Non‐Glutarimide Thalidomide Analogs: Stereodivergent Synthesis and Validation

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Fluorinated aminopiperidones, designed as non‐glutarimide thalidomide analogs, were synthesized with full regio‐ and stereocontrol. The C*–CF3 used as carbonyl surrogate improved solubility and membrane interactions while abolishing cereblon binding.
Boštjan Adamlje, Tihomir Tomašič, Christian Steinebach, Sebastian Ebeling, Alexander Herrmann, Marcus D. Hartmann, Jessica L. Horner, Kinjal Bhadresha, Cindy H. Chau, William D. Figg, Izidor Sosič, Andrej Emanuel Cotman   +11 more
wiley   +1 more source

Crystallization-Induced Diastereomer Transformations of Donor-Acceptor Cyclopropanes. [PDF]

J Am Chem Soc
Clarkson AJ, Fremin SO, Johnson JS.
europepmc   +1 more source

Methyl itaconate-anthracene adducts (MIAs) facilitate the enantiomeric separation of 1,1'-bi-2-naphthols <i>via</i> thin-layer chromatography (TLC) with trends predicted by molecular dynamics simulations. [PDF]

RSC Adv
Sinthopweha W, Khamto N, Rithchumpon P, Meepowpan P.   +3 more
europepmc   +1 more source

Catalytic Functionalization of Unactivated π‐Bonds Enabled by Bidentate Directing Auxiliaries

Angewandte Chemie, Volume 138, Issue 28, 6 July 2026.
This review explores how bidentate directing auxiliaries have advanced transition‐metal catalysis for unactivated alkene/alkyne functionalization. By leveraging chelated intermediates, bidentate directing auxiliaries enable precise hydrofunctionalization, difunctionalization, and C─H activation of π‐bonds with unique selectivity and reactivity.
Seunghyeon Cho, Al Vicente Riano D. Lisboa, Juntao Sun, Taeho Kang, Keary M. Engle   +4 more
wiley   +2 more sources

Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors.

Org Biomol Chem
Ghosh AK, Bhattacharjee A, Jayashankar U, Bogan SN, Mesecar AD.   +4 more
europepmc   +1 more source

A Novel Approach for the Synthesis of Peripherally Acting Dual Target Inhibitor of Cannabinoid-1 (CB1 Receptor) and Inducible Nitric Oxide Synthase (iNOS) (<i>S</i>-MRI-1867/Zevaquenabant). [PDF]

Molecules
Iyer MR.
europepmc   +1 more source