Results 111 to 120 of about 19,176 (260)

Diastereoselectivity in Photochemistry

International audience ; Diastereoselective photochemical reactions play an important role for asymmetric synthesis, for example for the synthesis of natural or biologically active compounds. Chirality is either induced by a chiral auxiliary or by a chiral centers already present in the substrates.
openaire   +2 more sources

Inverting the Diastereoselectivity of the Mukaiyama–Michael Addition with Graphite-Based Catalysts

, 2016
Here, we show that graphite-based catalysts, mainly graphite oxide (GO) and exfoliated GO, are effective recyclable catalysts for a relevant stereoselective Mukaiyama–Michael addition, outperforming currently available catalysts.
Marco Mauro (1640995), Laura Falivene (1414534), Luigi Cavallo (14607), Maria Rosaria Acocella (1848610), Gaetano Guerra (1500712)   +4 more
core   +1 more source

Enabling Cross‐Coupling Reactivity of α‐Pentafluorosulfanyl Compounds with a Thermally Stable Organozinc α‐SF5 Reagent

Chemistry – A European Journal, EarlyView.
This work describes the first example of a thermally stable α‐SF5 organometallic reagent, which allows for extensive downstream functionalization by allylation and acylation reactions under copper catalysis, as well as palladium‐catalyzed Negishi‐type cross‐coupling conditions up to 96% yield. In silico analysis shines initial light on the requirements
Lujie Xu, David Rombach
wiley   +1 more source

Multicomponent Hosomi–Sakurai Reaction on Isosorbide Derivatives

Molecules
Trimethylsilyl ethers of monoprotected isosorbide derivatives have been subjected to multicomponent Hosomi–Sakurai reactions with allyl trimethylsilane and various aldehydes (aromatic or aliphatic) under the catalysis of trimethylsilyl triflate.
Luca Banfi, Lucia Garcia de la Parte, Chiara Lambruschini, Lisa Moni, Daniel Rufo Perez, Renata Riva   +5 more
doaj   +1 more source

Theoretical Study on the Mechanism and Diastereoselectivity of NaBH₄ Reduction

, 2016
As the first step to understand the reaction mechanism and diastereoselectivity of sodium borohydride reduction of ketones, ab initio Car−Parrinello molecular dynamics simulation has been performed on a solution of NaBH4 in liquid methanol.
Daisuke Kaneno (2117665), Yasumitsu Suzuki (2385703), Shuji Tomoda (2117659)   +2 more
core   +1 more source

Access to Uncharted (Ethoxy)difluoromethylated‐Containing Tetrahydrofurans by Hydrogenation

Chemistry – A European Journal, EarlyView.
A Pd/C‐catalyzed selective hydrogenation of (ethoxy)difluoromethylated‐containing tetrahydrofurans was achieved. Depending on the pressure of H2, a divergent process led to either cis CF2CO2Et‐containing tetrahydrofurans or valuable α,α‐difluoro‐β‐hydroxyesters, offering key fluorinated building blocks for drug discovery while keeping the CF2CO2Et ...
Thibaud Charvillat, Victor Levet, Patrick Bernardelli, Marc Daumas, Hassan Oulyadi, Muriel Sebban, Vincent Ferey, Tatiana Besset   +7 more
wiley   +1 more source

Diastereoselectivity in the reduction of bicyclic enones with hindered hydrides [PDF]

, 2008
Reduction of five substituted octalones employing lithium tri-sec-butylborohydride (L-selectride®) in THF and ethyl ether led to allylic alcohols with moderate diastereoselectivity.
Tenius, Beatriz Soares Machado, Silveira, Leandro Greff da, Viegas Junior, Claudio, Victor, Mauricio Moraes, Oliveira, Eduardo Rolim de, Camozzato, Andreza Casanova   +5 more
core   +1 more source

Cobalt‐Catalyzed C(sp3)H Carbonylation Enabled by Mo(CO)6

European Journal of Organic Chemistry, EarlyView.
Cobalt‐catalyzed carbonylative C(sp3)H cyclization of aliphatic amides using Mo(CO)6 as a solid CO surrogate enables efficient access to substituted succinimides under operationally simple conditions. The carbonylation of unactivated C(sp3)H bonds represents an attractive strategy for the synthesis of valuable carbonyl‐containing compounds.
Emma Duro, Inés Alonso, Juan Carlos Carretero, Nuria Rodríguez, Javier Adrio   +4 more
wiley   +1 more source

π‐Extended Silyl Enolates as Emerging Platforms in Radical Chemistry

European Journal of Organic Chemistry, EarlyView.
This review covers the emerging role of π‐extended silyl polyenol ethers in radical chemistry. It highlights their versatile roles as electron‐rich SOMOphiles, silyl radical cation precursors, and nucleophilic partners in radical–polar crossover manifolds, while considering recent advances in photoredox catalysis, electrochemistry, and transition metal‐
Debora Guazzetti, Kelly Bugatti, Claudio Curti, Franca Zanardi   +3 more
wiley   +1 more source

A Straightforward Synthesis of Benzestrol by Matteson Homologation Using Chiral Benzyl Carbamates

European Journal of Organic Chemistry, EarlyView.
Benzestrol can easily be obtained stereoselectively via Matteson reaction using chiral Boronic esters and chiral benzyl carbamates. A straightforward and highly stereoselective synthesis of the non‐steroidal estrogen benzestrol is described based on Matteson homologations.
Max Benjamin Becker, Uli Kazmaier
wiley   +1 more source