Results 51 to 60 of about 109,445 (330)

Advances on Albumin‐Based Carriers for Anticancer Drug Delivery

Advanced NanoBiomed Research, EarlyView.
This study systematically classifies the drug delivery modes of albumin by examining the characteristics of its surface‐active groups and internal binding sites. It provides an in‐depth analysis of various drug delivery strategies and their corresponding targeting mechanisms.
Ruoli Zhou, Rongbin Zhong, Zhonghui Luo, Hua Wei, Cui‐Yun Yu   +4 more
wiley   +1 more source

Manual control analysis of drug effects on driving performance [PDF]

, 1981
The effects of secobarbital, diazepam, alcohol, and marihuana on car-driver transfer functions obtained using a driving simulator were studied. The first three substances, all CNS depressants, reduced gain, crossover frequency, and coherence which ...
Moskowitz, H., Smiley, A., Ziedman, K.
core   +1 more source

Systematic review of antiepileptic drugs’ safety and effectiveness in feline epilepsy [PDF]

, 2018
Understanding the efficacy and safety profile of antiepileptic drugs (AEDs) in feline epilepsy is a crucial consideration for managing this important brain disease.
A Klang, A Pakozdy, A Pakozdy, A Pakozdy, A Pellegrini, AD Quesnel, Akos Pakozdy, AM Wahle, AS Sawchuk, C Bertolani, CR Hooijmans, CW Dewey, D Hasegawa, D Hughes, D Moher, D Schwartz-Porsche, D Schwartz-Porsche, DB Roye, DE Cuff, DL Zoran, DM Boothe, DM Brewer, G Zaccara, G Zaccara, GE Solomon, GH Guyatt, H Volk, Holger A. Volk, JA Berlin, JA Wada, JAD Gasper, JM Ducote, KE Finnerty, KS Bailey, KS Bailey, LR Barnard, M Charalambous, M Charalambous, M Lowrie, M Podell, MA Cautela, MA Holmes, Marios Charalambous, MB Carnes, MJ Baho, NM van Gelder, O Engel, P Boydell, PN Papanikolaou, R Chou, S Cizinauskas, S Schriefl, S Wagner, SA Center, SD Ross, SF Bhatti, SM Cochrane, SM Cochrane, Sofie F. M. Bhatti   +58 more
core   +2 more sources

Medications, epilepsy and climate change: Added layers of complexity

British Journal of Clinical Pharmacology, EarlyView.
Climate change—the global crisis with pervasive health impacts—has adverse consequences for people with epilepsy (PWE) who have low quality of life due to poor seizure control, socioeconomic disadvantages and comorbidities. This review focuses on the potential effects of climate change on the pharmacological characteristics of antiseizure medications ...
Medine I. Gulcebi, Seyhmus Gavas, Sanjay M. Sisodiya   +2 more
wiley   +1 more source

Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels [PDF]

, 2013
Recent clinical data support the clinical use of oral lavender oil in patients suffering from subsyndromal anxiety. We identified the molecular mechanism of action that will alter the perception of lavender oil as a nonspecific ingredient of aromatherapy
Klugbauer, Norbert, Leuner, Kristina, Müller, Walter E., Nöldner, Michael, Schuwald, Anita Maria, Wilmes, Thomas   +5 more
core   +4 more sources

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Anxiolytic Effects of Indole Alkaloids From Rauvolfia ligustrina in Adult Zebrafish: Involvement of the GABAergic and 5‐HT Systems

Chemistry &Biodiversity, EarlyView.
ABSTRACT Benzodiazepines are widely used in the treatment of anxiety, but their use may be interrupted due to side effects. This study evaluated the indole alkaloids isocarapanaubine (indole alkaloid 1 [AIN1]) and 18‐β‐hydroxy‐3‐epi‐α‐yohimbine (indole alkaloid 2 [AIN2]), extracted from Rauvolfia ligustrina, in adult zebrafish.
Nádia Aguiar Portela Pinheiro, Ivana Carneiro Romão, Amanda Maria Barros Alves, Sônia Maria Costa Siqueira, Jane Eire Silva Alencar de Menezes, Emmanuel Silva Marinho, Márcia Machado Marinho, Herbert de Sousa Magalhães, Andreia Ferreira de Castro Gomes, Otília Deusdênia Loiola Pessoa, Hélcio Silva dos Santos   +10 more
wiley   +1 more source

Sedative Effects of Intraperitoneal Diazepam in Mice

International Journal of Integrated Health Sciences, 2023
Objectives: To determine the effectiveness of Diazepam in comparison with Phenobarbital. Methods: Twenty-seven male Swiss Webster mice were used and randomly divided into three groups of negative control (NS), positive control (Phenobarbital), and ...
Marsha Vania, Shinta Dewi Permata Sari, Bambang Siswitono, Endin Nokik Stujanna   +3 more
doaj  

Effects of filtration sterilization on the stability of ketamine, selected benzodiazepines and metabolites in female urine [PDF]

, 2017
Benzodiazepines (Benzos) and ketamine (K) are compounds that have been encountered in Drug-Facilitated Sexual Assault (DFSA) cases. Due to the intimate nature of these crimes, evidence collection is often postponed due to delays and/or reluctance in ...
Zhen, Lin
core   +1 more source

Interventions for treating hyperemesis gravidarum. [PDF]

, 2016
BACKGROUND: Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy affecting 0.3% to 1.0% of pregnancies, and is one of the most common indications for hospitalization during pregnancy.
Abas, Adamczak, Arsenault, Bailit, Bondok, Bowen, Capp, Carlsson, Cox, Ditto, Dodds, Duggar, Eftekhari, Eliakim, Erez, Fell, Ferruti, Fischer-Rasmussen, Fletcher, Fletcher, Gadsby, Gawande, Gill, Goodwin, Gordon, Habek, He, Heazell, Holmgren, Ismail, Jarvis, Kashifard, Kelly, Klebanoff, Koren, Koren, Koren, Koren, Kramer, Lask, Ling, Liu, Magee, Maina, Maltepe, Maltepe, Mao, Mao, Matok, Matok, Matthews, Mazzotta, McCarthy, McCarthy, McParlin, Mella, Miller, Moran, Munch, Nelson-Piercy, Neri, Neutel, Niebyl, Oliveira, Ozgoli, Pasternak, Philip, Piwko, Pongrojpaw, Poursharif, Poursharif, Power, Price, Rhodes, Rhodes, Rosen, Safari, Safari, Saha, Shin, Shin, Sonkusare, Sullivan, Sullivan, Swallow, Tabatabaii, Tan, Tan, Tan, Tasci, Veciana, Wibowo, Willetts, Ylikorkala, Yost, Zhou, Ziaei   +96 more
core   +2 more sources