Results 51 to 60 of about 83,280 (287)
Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 60-70, January 2023., 2023 Abstract Use of benzodiazepines (BZ) and related drugs is subject to considerable debate due to problems with dependency and adverse events. We aimed to describe and compare their use across the Nordic countries. Data on the use of clonazepam, BZ‐sedatives, BZ‐hypnotics, and benzodiazepine‐related drugs (BZRD) in adults (≥20 years) were obtained from ...
Mikkel Højlund +8 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin +9 more
wiley +1 more source
Epilepsia, 2013 A diazepam auto‐injector (AI) has been developed for intramuscular administration to treat acute repetitive seizures (ARS). The objective of this study was to evaluate the efficacy and safety of the diazepam AI when administered by caregivers to control ...
B. Abou-Khalil +9 more
semanticscholar +1 more source
Rethinking Chlorine: Essential Chemical or Replaceable Risk?
ChemSusChem, Accepted Article.This review critically examines the dual nature of chlorine as both an indispensable base chemical and a potential risk. Chlorine and its by‐product hydrogen chloride play essential roles in the production of pharmaceuticals, plastics, agrochemicals, and disinfectants.
Johannes Schwan +6 more
wiley +1 more source
The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease
Brain Pathology, Volume 33, Issue 1, January 2023., 2023 Abstract Alzheimer's disease (AD) is the most common neurological disease, which is associated with gradual memory loss and correlated with synaptic hyperactivity and abnormal oscillatory rhythmic brain activity that precedes phenotypic alterations and is partly responsible for the spread of the disease pathology.
Afia B. Ali +2 more
wiley +1 more source
Archives of Anesthesia and Critical Care, 2019 Background: The purpose of this study was to compare the effectiveness and side effects of diazepam and midazolam administration for conscious sedation in subjects who undergoing cataract surgery.
Mehdi Sanatkar +2 more
doaj +1 more source
European Journal of Neuroscience, 2013 The K+‐Cl− cotransporter type 2 is the major Cl− extrusion mechanism in most adult neurons. This process in turn leads to Cl− influx upon activation of γ‐aminobutyric acid type A (GABAA) receptors and the canonical hyperpolarising inhibitory postsynaptic
Tarek Z. Deeb +4 more
semanticscholar +1 more source
Drug Testing and Analysis, EarlyView.In forensic bioanalysis, often multianalyte approaches are used given their increased effectiveness but can be difficult to develop and maintain in the laboratory, for example, in terms of calibrator solution preparation. A fast, simple, and robust liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the quantification of 82 classic ...
Andrea E. Steuer +3 more
wiley +1 more source
Development and Characterization of Lyophilized Diazepam-Loaded Polymeric Micelles
AAPS PharmSciTech, 2013 Polymeric micelles were studied as delivery carriers of diazepam, a practically insoluble drug in water, for rectal administration. The diazepam-loaded polymeric micelles were developed by using poloxamer 407 (P407), poloxamer 188, and d-α-tocopheryl ...
J. Suksiriworapong +4 more
semanticscholar +1 more source
Rapid Analytical Method for Quantification of Gamma‐Hydroxybutyrate (GHB) in Hair by UPLC‐MS/MS
Drug Testing and Analysis, EarlyView.A rapid and simple UPLC‐MS/MS method for quantification of GHB in 10 mg of hair was developed. The method was satisfactorily validated, showing a linear range of 0.5–50 ng/mg, which allows us to quantify endogenous and exogenous GHB concentrations.
Miriam Blanco‐Ces +5 more
wiley +1 more source