Results 51 to 60 of about 86,598 (299)

Implications of Seizure-Cluster Treatment on Healthcare Utilization: Use of Approved Rescue Medications

Neuropsychiatric Disease and Treatment, 2022
Adrian L Rabinowicz,1 Edward Faught,2 David F Cook,1 Enrique Carrazana1,3 1Clinical Development & Medical Affairs, Neurelis, Inc., San Diego, CA, USA; 2Emory Epilepsy Program, Emory University School of Medicine, Atlanta, GA, USA; 3John A.
Rabinowicz AL, Faught E, Cook DF, Carrazana E   +3 more
doaj  

Structure of Heteropentameric GABAA Receptors and Receptor-Anchoring Properties of Gephyrin

Frontiers in Molecular Neuroscience, 2019
γ-Aminobutyric acid type A receptors (GABAARs) mediate the majority of fast synaptic inhibition in the central nervous system (CNS). GABAARs belong to the Cys-loop superfamily of pentameric ligand-gated ion channels (pLGIC) and are assembled from 19 ...
Vikram Babu Kasaragod, Hermann Schindelin   +1 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Diazepam exposure associated with an increased risk of acute kidney injury in children: an observational cohort study

BMC Pediatrics
Background Potentially nephrotoxic drugs play an important role in acute kidney injury (AKI) in children. In the previous pharmacovigilance study, we found a statistical correlation between diazepam and AKI in children, but the causality needs to be ...
Miao Zhang, Liang Huang, Yu Zhu, Linan Zeng, Guo Cheng, Hailong Li, Lingli Zhang   +6 more
doaj   +1 more source

A multi‐feature method for real‐time seizure detection in pediatric intensive care unit

Epilepsia Open, EarlyView.
Abstract Purpose Continuous electroencephalogram (cEEG) monitoring is an important technique used in detecting electroclinical seizures in the pediatric intensive care unit (PICU). This study developed an artificial intelligence method for the real‐time automatic detection of seizures in the PICU.
Tian Sang, Jiong Deng, Tong Zhao, Qi Zhang, Qiao Guan, Yanqin Lei, Yuxiang Yan, Bo Hong, Ningning Wei, Yuwu Jiang, Ying Wang   +10 more
wiley   +1 more source

L-Quebrachitol Enhances Sedative Effect of Diazepam Through GABAergic Pathway: Animal and Computational Studies. [PDF]

Brain Behav
L‐quebrachitol (LQL) significantly enhanced the sedative effects of diazepam in thiopental sodium‐induced chicks by reducing sleep latency and prolonging duration. Molecular docking revealed LQL's interaction with GABAA receptor (α1 and β2 subunits), supporting a GABAergic mechanism and highlighting its potential as a safe, natural sedative agent ...
Asrafi A, Aslam M, Al Hasan MS, Uddin MB, Mia E, Alshahrani MY, Bithi SA, Akter MS, Hossain MA, Islam MT.   +9 more
europepmc   +2 more sources

In‐hospital outcomes of lacosamide versus levetiracetam for early adjunctive treatment of status epilepticus: A Nationwide Japanese retrospective cohort study

Epilepsia Open, EarlyView.
Abstract Objective Status epilepticus (SE) is a neurological emergency requiring immediate treatment. Although intravenous lacosamide (LCM) is used for the management of epilepsy, its effectiveness in treating SE remains unclear. We aimed to compare the in‐hospital outcomes between intravenous LCM and levetiracetam (LEV) as an early adjunctive therapy ...
Yumiko Nakamura, Shotaro Aso, Hideo Yasunaga, Hiroki Matsui, Yuichiro Shirota, Masashi Hamada, Kiyohide Fushimi, Tatsushi Toda, Satoshi Kodama   +8 more
wiley   +1 more source

Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo

Frontiers in Pharmacology, 2020
BackgroundDiazepam is a benzodiazepine drug used to treat anxiety, insomnia, and muscle spasms. Imperatorin is a phytochemical isolated from medicinal plants and is widely used in herbal medicine. The aim of this study was to investigate the interactions
Yunfang Zhou, Deru Meng, Deru Meng, Feifei Chen, Zhengping Wu, Binglan Wang, Shuanghu Wang, Peiwu Geng, Dapeng Dai, Quan Zhou, Weiwen Qiu, Weiwen Qiu, Weiwen Qiu   +12 more
doaj   +1 more source

Cost‐effectiveness of fenfluramine as add‐on treatment in the management of Dravet Syndrome: A real‐world multicenter study

Epilepsia Open, EarlyView.
Abstract Objective Dravet syndrome (DS) is a rare disease with a high clinical and socioeconomic impact on patients, society, and the healthcare system. The recent approval of therapies such as fenfluramine (FFA) has transformed the treatment landscape; however, data on their cost‐effectiveness are still scarce. This study evaluates the real‐world cost‐
Paolo A. Cortesi, Carla Fornari, Alessandra Boncristiano, Rita Facchetti, Simona Balestrini, Viola Doccini, Nicola Specchio, Nicola Pietrafusa, Marina Trivisano, Francesca Darra, Alberto Cossu, Domenica I. Battaglia, Michela Quintiliani, Maria L. Gambardella, Lorenzo G. Mantovani, Renzo Guerrini   +15 more
wiley   +1 more source

Use of Diazepam to Correct Hemodynamic Changes in Explosive Mine Injury: Experimental Study

Общая реаниматология, 2007
Objective. To study the hemodynamic effect of benzodiazepine tranquilizers in explosive mine injury in an experiment.Materials and methods. The study was performed on non-inbred male rats; hemodynamic parameters were examined at the systemic, organ, and ...
V. N. Yelsky, G. K. Krivobok, Ye. V. Antonov   +2 more
doaj   +1 more source