Combined Effects of Diazoxide and Moderate-Intensity Exercise on the Restoration of Redox Balance Post-Fatigue in Fast- and Slow-Twitch Skeletal Muscles of Hypertensive Rats [PDF]
BiologyMuscle fatigue, defined as a decline in force generation, is closely linked to redox imbalance—a condition exacerbated by oxidative stress in hypertension. This study investigated the effects of diazoxide administration and moderate-intensity exercise on
Estefanía Bravo-Sánchez +10 more
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Real-world experience with the use of diazoxide among people living with congenital hyperinsulinism and their caregivers [PDF]
Frontiers in EndocrinologyIntroductionCongenital hyperinsulinism (HI) is a rare disease that causes severe hypoglycemia. Diazoxide is the first-line treatment; however, many individuals using diazoxide continue to experience hypoglycemia. Diazoxide is associated with side effects
Tai L. S. Pasquini +8 more
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Trisomy 13 as a risk factor for pulmonary hypertension induced by diazoxide [PDF]
Annals of Pediatric CardiologyIntroduction: Diazoxide has been used globally for hyperinsulinemic hypoglycemia. However, serious adverse drug reactions, such as pulmonary hypertension (PH), are major concerns.
Kazu Ishikawa +4 more
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Identification of an ABCC8 variant in a kindred with transient diazoxide responsive hyperinsulinism [PDF]
Endocrinology, Diabetes & Metabolism Case ReportsCongenital hyperinsulinism is a rare disorder characterized by hypoglycemia and inappropriately elevated insulin levels. The genetics of congenital hyperinsulinism is complex, with the most common cause being pathogenic variants in the ATP-sensitive ...
Ryan L Smith, Stephen I Stone
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Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma [PDF]
Frontiers in EndocrinologyDefinitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the
Run Ting Chin +3 more
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Severe transient neonatal hyperinsulinism: First Peruvian case series [PDF]
SAGE Open Medical Case ReportsCongenital hyperinsulinism is characterized by dysregulated insulin secretion and is the most common and severe cause of persistent hypoglycemia in pediatrics. Brain damage rates can be as high as 50% due to inadequate treatment.
Manuel André Virú-Loza +2 more
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Heliyon, 2023 Diazoxide is a potential candidate for the treatment of transitional hypoglycaemia in infants. A clinical trial is currently underway to investigate whether low-dose oral diazoxide is beneficial for severe or recurrent transitional neonatal hypoglycaemia
Trusha J. Purohit +4 more
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Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario
Frontiers in Cardiovascular Medicine, 2023 IntroductionDiazoxide is a powerful cardioprotective agent that activates mitochondrial ATP-dependent K-channels and stimulates mitochondrial respiration.
Petra Kleinbongard +3 more
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Diazoxide-Induced Hypertrichosis in a Neonate With Transient Hyperinsulinism
Clinical Medicine Insights: Case Reports, 2023 Diazoxide is one of the FDA-approved pharmacologic treatments for hyperinsulinemic hypoglycemia, however, its adverse effects in infants are not well described. We reported a 37-week-old boy with the diagnosis of hypoglycemia.
Seyyed Javad Boskabadi +3 more
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Frontiers in Cardiovascular Medicine, 2021 Background: Previous studies have shown that diazoxide can protect against myocardial ischemia-reperfusion injury (MIRI). The intranuclear hypoxia-inducible factor-1 (HIF-1)/hypoxia-response element (HRE) pathway has been shown to withstand cellular ...
Xi-Yuan Chen +9 more
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