Sirolimus therapy in a child with partially diazoxide-responsive hyperinsulinaemic hypoglycaemia
Endocrinology, Diabetes & Metabolism Case Reports, 2016 Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and it’s management is challenging.
Kah-Yin Loke +5 more
doaj +1 more source
Treatment with low-dose diazoxide in two growth-retarded prepubertal girls with glycogen storage disease type Ia resulted in catch-up growth [PDF]
, 2018 Two originally prepubertal girls suffering from glycogen storage disease type Ia and short stature were treated with low-dose diazoxide (3-4.8 mg/kg per day) for 7 and 4 years, respectively.
Mullis, P., Nuoffer, J., Wiesmann, U.
core
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, Volume 599, Issue 11, Page 1595-1608, June 2025.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion [PDF]
, 2017 Glucagon plays a major role in the regulation of glucose homeostasis during fed and fasting states. However, the mechanisms responsible for the regulation of pancreatic α cell mass and function are not completely understood.
Alvin C. Powers +17 more
core +1 more source
Complex Patterns of Metabolic and Ca2+ Entrainment in Pancreatic Islets by Oscillatory Glucose [PDF]
, 1998 Glucose-stimulated insulin secretion is pulsatile and driven by intrinsic oscillations in metabolism, electrical activity, and Ca(2+) in pancreatic islets.
Bergsten +51 more
core +2 more sources
Brain injury due to persistent hyperinsulinemic hypoglycemia of infancy [PDF]
, 2007 A
De Visschere, Pieter +3 more
core +2 more sources
Anticonvulsant Effect of Diazoxide against Dichlorvos-Induced Seizures in Mice
The Scientific World Journal, 2013 Dichlorvos, a synthetic organophosphate toxin, is used as pesticides. These toxins can be used as pesticides in farming and medicine for the devastation and/or elimination of ectoparasites of animals.
Amin Jazayeri +2 more
doaj +1 more source
Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. [PDF]
, 2005 BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M +13 more
core +3 more sources
Effects of Fetal Exposure to Diazoxide in Man [PDF]
, 1972 R. D. G. Milner, S K Chouksey
openalex +1 more source