Results 91 to 100 of about 13,368 (258)
Acta Physiologica, Volume 241, Issue 2, February 2025.Abstract Aim Somatostatin from pancreatic δ‐cells is a paracrine regulator of insulin and glucagon secretion, but the release kinetics and whether secretion is altered in diabetes is unclear. This study aimed to improve understanding of somatostatin secretion by developing a tool for real‐time detection of somatostatin release from individual ...
Mingyu Yang +5 more
wiley +1 more source
Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion [PDF]
, 2001 A female infant of nonconsanguineous Indian parents presented at 4 months with a hypoglycemic convulsion. Further episodes of hypoketotic hypoglycemia were associated with inappropriately elevated plasma insulin concentrations.
Aynsley-Green, A +9 more
core
Blockade of microglial KATP-channel abrogates suppression of inflammatory-mediated inhibition of neural precursor cells [PDF]
, 2014 Microglia positively affect neural progenitor cell physiology through the release of inflammatory mediators or trophic factors. We demonstrated previously that reactive microglia foster KATP-channel expression and that blocking this channel using ...
Aarum +46 more
core +1 more source
Strain, Volume 61, Issue 1, February 2025.Abstract Even though the simulations used to predict failure are becoming increasingly predictive, complex multiaxial loading tests are still required to validate the design of structural components in a wide range of industries. Large specimen testing often requires two different scales.
J. Serra +4 more
wiley +1 more source
Frontiers in Physiology, 2020 Voltage-dependent Ca2+ channels and store-operated Ca2+ channels (SOCs) are the major routes of Ca2+ entry into mammalian cells. Previously, we reported that pharmacological preconditioning (PPC) leads to a decrease in the amplitude of L-type calcium ...
Raúl Sampieri +5 more
doaj +1 more source
Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus [PDF]
, 2016 Diazoxide, a well-known mitochondrial KATP channel opener with neuroprotective effects, has been proposed for the effective and safe treatment of neuroinflammation.
Andrade, Carmen +6 more
core +1 more source
Chemistry &Biodiversity, Volume 22, Issue 1, January 2025.Abstract Leishmaniasis is a vector‐borne, parasitic disease affecting millions of people and animals worldwide. Current therapeutic options have proven to be ineffective in both treating the disease and preventing its spread. As a result, new drugs must be developed to effectively combat this disease.
Nadine Henning +5 more
wiley +1 more source
Successful use of long acting octreotide in two cases with Beckwith-Wiedemann syndrome and severe hypoglycemia [PDF]
, 2014 INTRODUCTION: Hyperinsulinism associated with Beckwith-Wiedemann syndrome (BWS) can occur in about 50% of cases, causing hypoglycemia of variable severity. Parenteral use of octreotide may be indicated if unresponsive to diazoxide.
Hiba Al-Zubeidi +2 more
core +1 more source
The Role of Ion Channels in Pulmonary Hypertension: A Review
Pulmonary Circulation, Volume 15, Issue 1, January 2025.ABSTRACT Pulmonary hypertension (PH) constitutes a critical challenge in cardiopulmonary medicine with a pathogenesis that is multifaceted and intricate. Ion channels, crucial determinants of cellular electrochemical gradient modulation, have emerged as significant participants in the pathophysiological progression of PH.
Han‐Fei Li +11 more
wiley +1 more source
Necrotizing enterocolitis following diazoxide therapy for persistent neonatal hypoglycemia
Journal of Pediatric Surgery Case Reports, 2020 Recalcitrant neonatal hypoglycemia poses a treatment challenge for clinicians. When a patient's hypoglycemia does not respond to dextrose infusion, several medication options are available, including diazoxide(1,2).
Christina M. Theodorou, Shinjiro Hirose
doaj