Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations [PDF]
, 2010 Objective: The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY).
Ashcroft +19 more
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Diazoxide use for neonatal hyperinsulinaemic hypoglycaemia in a low-resource setting: A Case Report
Annals of Health Research, 2020 The management of neonatal hyperinsulinaemic hypoglycaemia remains a major challenge in hospitalized newborns globally. Diazoxide is one of the recommended therapeutic options.
Adekoya AO +5 more
doaj +1 more source
K(ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action via antioxidative pathway activation. [PDF]
PLoS ONE, 2013 Pharmacological modulation of ATP-sensitive potassium channels has become a promising new therapeutic approach for the treatment of neurodegenerative diseases due to their role in mitochondrial and cellular protection.
Noemí Virgili +6 more
doaj +1 more source
Biology, 2022 Obesity is a chronic disease that impairs skeletal muscle function, affects the ability to contract, and promotes the development of fatigue. For this reason, the study of treatments that seek to reduce the harmful effects of obesity on muscle tissue has
Mariana Gómez-Barroso +7 more
doaj +1 more source
Exceptional diazoxide sensitivity in hyperinsulinaemic hypoglycaemia due to a novel HNF4A mutation
Endocrinology, Diabetes & Metabolism Case Reports, 2019 Diazoxide is the first-line treatment for patients with hyperinsulinaemic hypoglycaemia (HH). Approximately 50% of patients with HH are diazoxide resistant.
Ved Bhushan Arya +4 more
doaj +1 more source
Diazoxide for Neonatal Hyperinsulinemic Hypoglycemia and Pulmonary Hypertension
Children, 2022 Hypoglycemia in neonates is associated with long-term neurodevelopmental effects. Hyperinsulinemic hypoglycemia (HH) is the most common cause of persistent hypoglycemia in neonatal intensive care units.
Shoshana Newman-Lindsay +2 more
doaj +1 more source
Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]
, 2017 ATP-sensitive potassium channels (K(ATP) channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K(ATP) channels are essential for coupling glucose metabolism to insulin secretion.
Conway, Hannah +8 more
core +2 more sources
Hyperinsulinism-hyperammonaemia syndrome: novel mutations in the GLUD1 gene and genotype-phenotype correlations [PDF]
, 2009 Background: Activating mutations in the GLUD1 gene (which encodes for the intra-mitochondrial enzyme glutamate dehydrogenase, GDH) cause the hyperinsulinism–hyperammonaemia (HI/HA) syndrome.
Banerjee, I. +9 more
core +2 more sources
Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]
, 1999 Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija +4 more
core +1 more source
KATP Channel Openers Have Opposite Effects on Mitochondrial Respiration Under Different Energetic Conditions [PDF]
, 2008 Mitochondrial (m) KATP channel opening has been implicated in triggering cardiac preconditioning. Its consequence on mitochondrial respiration, however, remains unclear. We investigated the effects of two different KATP channel openers and antagonists on
Camara, Amadou K.S. +5 more
core +2 more sources