Results 31 to 40 of about 14,174 (227)

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection [PDF]

, 2004
Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling.
Duchen, M, Hausenloy, D, Wynne, A, Yellon, D   +3 more
core   +1 more source

The mitochondrial K-ATP channel opener diazoxide upregulates STIM1 and Orai1 via ROS and the MAPK pathway in adult rat cardiomyocytes

Cell & Bioscience, 2020
Background Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischemia–reperfusion, protecting the ...
Joice T. Gavali, Elba D. Carrillo, María C. García, Jorge A. Sánchez   +3 more
doaj   +1 more source

Diazoxide promotes oligodendrocyte precursor cell proliferation and myelination. [PDF]

PLoS ONE, 2010
Several clinical conditions are associated with white matter injury, including periventricular white matter injury (PWMI), which is a form of brain injury sustained by preterm infants.
Birgit Fogal, Carolyn McClaskey, Sha Yan, Henglin Yan, Scott A Rivkees   +4 more
doaj   +1 more source

Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. [PDF]

, 2016
Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an important factor during development of diabetes.
Ahlstedt, I., Elhachmane, M., Gopel, S., Pedersen, MORTEN GRAM   +3 more
core   +1 more source

The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]

, 2012
This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L, Krafft, Paul R, Leitzke, Arthur S, Tang, Jiping, Van Allen, Nicole R, Zhang, John H   +5 more
core   +1 more source

The danger of diazoxide in the neonatal intensive care unit

Therapeutic Advances in Drug Safety, 2021
Background: The most common cause of persistent hypoglycemia in infancy is hyperinsulinemic hypoglycemia. When conservative measures fail, providers often use medications to treat persistent hypoglycemia.
Jay Desai, Logan Key, Alyson Swindall, Kan Gaston, Ajay J. Talati   +4 more
doaj   +1 more source

Diazoxide and Exercise Enhance Muscle Contraction during Obesity by Decreasing ROS Levels, Lipid Peroxidation, and Improving Glutathione Redox Status

Antioxidants, 2020
Obesity causes insulin resistance and hyperinsulinemia which causes skeletal muscle dysfunction resulting in a decrease in contraction force and a reduced capacity to avoid fatigue, which overall, causes an increase in oxidative stress.
Mariana Gómez-Barroso, Koré M. Moreno-Calderón, Elizabeth Sánchez-Duarte, Christian Cortés-Rojo, Alfredo Saavedra-Molina, Alain R. Rodríguez-Orozco, Rocío Montoya-Pérez   +6 more
doaj   +1 more source

Pharmacological Preconditioning with Diazoxide in the Experimental Hypothermic Circulatory Arrest Model [PDF]

, 2017
Background: Hypothermic circulatory arrest includes a remarkable risk for neurological injury. Diazoxide, a mitochondrial adenosine triphosphate-dependent potassium ion (K+ATP) channel opener, is known to have cardioprotective effects.
Anttila, Tuomas, Anttila, Vesa, Arvola, Oiva, Haapanen, Henri, Herajarvi, Johanna, Juvonen, Tatu, Karihtala, Peeter, Kiviluoma, Kai, Puistola, Ulla, Tuominen, Hannu   +9 more
core   +1 more source

A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11. [PDF]

, 2017
The ATP-sensitive potassium channel (KATP) functions as a metabo-electric transducer in regulating insulin secretion from pancreatic β-cells. The pancreatic KATP channel is composed of a pore-forming inwardly-rectifying potassium channel, Kir6.2, and a ...
Ferrara, Christine, German, Michael, Gitelman, Stephen, Long, Roger, Yang, Shi-Bing, Yang, Yen-Yu   +5 more
core   +1 more source

Diazoxide toxicity in congenital hyperinsulinism: A case report.

World J Clin Pediatr
Pajno R, Visconti C, Bucolo C, Guarneri MP, Del Barba P, Silvani P, Gregnanin M, Barera G.   +7 more
europepmc   +2 more sources