Tuberculostearic Acid Controls Mycobacterial Membrane Compartmentalization [PDF]
mBio, 2023 The intracellular membrane domain (IMD) is a laterally discrete region of the mycobacterial plasma membrane, enriched in the subpolar region of the rod-shaped cell. Here, we report genome-wide transposon sequencing to discover the controllers of membrane
Malavika Prithviraj +9 more
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Structure Prediction and Potential Inhibitors Docking of Enterovirus 2C Proteins [PDF]
Frontiers in Microbiology, 2022 Human enterovirus infections are mostly asymptomatic and occasionally could be severe and life-threatening. The conserved non-structural 2C from enteroviruses protein is a promising target in antiviral therapies against human enteroviruses. Understanding
Daoqun Li +5 more
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Electrochemical Detection of a Local Anesthetic Dibucaine at Arrays of Liquid|Liquid MicroInterfaces
Chemosensors, 2021 Electrochemical characterization and detection of protonated dibucaine (DIC+) at microinterface array across water|1,6-dichlorohexane were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV).
Eissa Mohamed Almbrok +2 more
exaly +3 more sources
Approved drugs successfully repurposed against Leishmania based on machine learning predictions [PDF]
Frontiers in Cellular and Infection MicrobiologyDrug repurposing is a promising approach towards the discovery of novel treatments against Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing both costs and duration of the drug discovery process.
Rafeh Oualha +3 more
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Prolonged paralysis following mivacurium administration in a pediatric patient with previously undiagnosed pseudocholinesterase deficiency: a case report [PDF]
BMC PediatricsBackground Pseudocholinesterase, an enzyme produced by the liver and abundantly present in plasma, plays a role in the metabolism of neuromuscular blocking agents such as mivacurium.
Davut Deniz Uzun +6 more
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Solvent-Driven Enrichment and Multiplex Analysis of Local Anesthetics by Thin-Layer Chromatography Coupled with Surface-Enhanced Raman Spectroscopy [PDF]
MoleculesLocal anesthetics have been widely used in clinical analgesia due to their ability to provide effective regional pain management. Accurate measurement of local anesthetics in body fluids is crucial for ensuring patient medication safety and optimizing ...
Huimin Sui +9 more
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Picornavirus 2C proteins: structure-function relationships and interactions with host factors [PDF]
Frontiers in Cellular and Infection MicrobiologyPicornaviruses, which are positive-stranded, non-enveloped RNA viruses, are known to infect people and animals with a broad spectrum of diseases. Among the nonstructural proteins in picornaviruses, 2C proteins are highly conserved and exhibit multiple ...
Chunhui Yin +14 more
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Dibucaine Inhibition of Serum Cholinesterase [PDF]
BMB Reports, 2003 The dibucaine number (DN) was determined for serum cholinesterase (EC 3.1.1.8, SChE) in plasma samples. The ones with a DN of 79-82 were used, because they had the "usual" SChE variant. The enzyme was assayed colorimetrically by the reaction of 5,5'-dithiobis-[2-nitrobenzoic acid] (DTNB) with the free sulfhydryl groups of thiocholine that were produced
exaly +3 more sources
Dysmetabolic encephalopathy of the maternity hospital associated with spinal anesthesia
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2023 The review article discusses in detail the problem of complications in maternity patients associated with spinal anesthesia and cesarean section surgery.
A. A. Malkova +2 more
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International Journal of Electrochemical Science, 2021 In this work, the electrochemical behaviour of diclofenac anion and dibucaine cation via a water|1,6-dichlorohexane liquid | liquid interface system was characterised.
E.M. Almbrok +3 more
doaj +1 more source