Prolonged apnea during electroconvulsive therapy in monozygotic twins: case reports
Annals of General Psychiatry, 2011 In the present work, we report two cases of monozygotic twins who developed prolonged apnea during electroconvulsive therapy (ECT) as a complication of anesthesia. In both cases, prolonged action of succinylcholine caused by a butyrylcholinesterase (BCHE)
Zwanzger Peter, Zavorotnyy Maxim
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Approved drugs successfully repurposed against Leishmania based on machine learning predictions [PDF]
Frontiers in Cellular and Infection MicrobiologyDrug repurposing is a promising approach towards the discovery of novel treatments against Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing both costs and duration of the drug discovery process.
Rafeh Oualha +3 more
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Prolonged paralysis following mivacurium administration in a pediatric patient with previously undiagnosed pseudocholinesterase deficiency: a case report [PDF]
BMC PediatricsBackground Pseudocholinesterase, an enzyme produced by the liver and abundantly present in plasma, plays a role in the metabolism of neuromuscular blocking agents such as mivacurium.
Davut Deniz Uzun +6 more
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Solvent-Driven Enrichment and Multiplex Analysis of Local Anesthetics by Thin-Layer Chromatography Coupled with Surface-Enhanced Raman Spectroscopy [PDF]
MoleculesLocal anesthetics have been widely used in clinical analgesia due to their ability to provide effective regional pain management. Accurate measurement of local anesthetics in body fluids is crucial for ensuring patient medication safety and optimizing ...
Huimin Sui +9 more
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Picornavirus 2C proteins: structure-function relationships and interactions with host factors [PDF]
Frontiers in Cellular and Infection MicrobiologyPicornaviruses, which are positive-stranded, non-enveloped RNA viruses, are known to infect people and animals with a broad spectrum of diseases. Among the nonstructural proteins in picornaviruses, 2C proteins are highly conserved and exhibit multiple ...
Chunhui Yin +14 more
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Defining the polycystin pharmacophore through high-throughput screening and computational biophysics. [PDF]
Br J PharmacolAn unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Guadarrama E, Vanoye CG, DeCaen PG.
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The Reduction of Tau Hyperphosphorylation by Cornel Iridoid Glycosides Is Mediated by Their Influence on Calpain Activity. [PDF]
Evid Based Complement Alternat Med, 2022 Alzheimer’s disease (AD) is the most common type of dementia, and the abnormal hyperphosphorylation of the tau protein is the main component of its pathogenesis. Calpain was found to be abnormally activated in neurofibrillary tangles (NFTs) in a previous report.
Guo K, Yang C, Zhang L.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 BACKGROUND Male infertility is a worldwide problem but few treatments, especially irradiation-induced testicular injury. The aim of this research was to investigate novel drugs for the treatment of irradiation-induced testicular injury.
L. Ran +6 more
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Dysmetabolic encephalopathy of the maternity hospital associated with spinal anesthesia
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2023 The review article discusses in detail the problem of complications in maternity patients associated with spinal anesthesia and cesarean section surgery.
A. A. Malkova +2 more
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