Results 11 to 20 of about 1,590 (187)
Local anaesthetic systemic toxicity following oral ingestion in a child: Revisiting dibucaine
Indian Journal of Anaesthesia, 2017 Dibucaine, a potent and toxic local anaesthetic, although currently withdrawn by the United States Food and Drug Administration for use as a spinal anaesthetic, continues to remain available in many over-the-counter topical formulations.
Raylene Dias +3 more
doaj +2 more sources
Dibucaine mitigates spreading depolarization in human neocortical slices and prevents acute dendritic injury in the ischemic rodent neocortex. [PDF]
PLoS ONE, 2011 Spreading depolarizations that occur in patients with malignant stroke, subarachnoid/intracranial hemorrhage, and traumatic brain injury are known to facilitate neuronal damage in metabolically compromised brain tissue.
W Christopher Risher +4 more
doaj +2 more sources
Solid Lipid Nanoparticles for Dibucaine Sustained Release
Pharmaceutics, 2018 Dibucaine (DBC) is among the more potent long-acting local anesthetics (LA), and it is also one of the most toxic. Over the last decades, solid lipid nanoparticles (SLN) have been developed as promising carriers for drug delivery.
Raquel de M. Barbosa +8 more
doaj +2 more sources
International Journal of Electrochemical Science, 2021 In this study, electrochemical characterization and detection of an anti-inflammatory drug diclofenac (DCF) and a local anesthetic drug dibucaine (DIC) at synthetic saliva|1,6- dichlorohexane interface were carried out for the first time using cyclic ...
E.M. Almbrok +3 more
doaj +2 more sources
In vitro release of dibucaine hydrochloride from chitosan semisolid vehicles: emulsion and hydrophilic gels [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2017 Context: Chitosan has received attention as a functional, sustainably renewable, nontoxic and biodegradable biopolymer for pharmaceutical applications.
Nilia de la Paz +6 more
doaj +1 more source
Defining the polycystin pharmacophore through high-throughput screening and computational biophysics. [PDF]
Br J PharmacolAn unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Guadarrama E, Vanoye CG, DeCaen PG.
europepmc +2 more sources
A Novel Pathway of Functional microRNA Uptake and Mitochondria Delivery
Advanced Science, Volume 10, Issue 24, August 25, 2023., 2023 In the presence of serum, microRNAs (miRNAs) spontaneously form ≈110 nm nanoparticles, mediated bycationic proteins. When depleted, miRNA uptake is blocked. Unlike lysosome‐located, nanoparticle‐delivere mechanism are preferentially delivered to mitochondria of recipient cells by PNPT1.
Jiachen Liu +13 more
wiley +1 more source
Clinical Case Reports, Volume 11, Issue 8, August 2023., 2023 Key Clinical Message The perioperative control of ammonia, reduction of stress, and administration of drugs tolerated in type 1 citrullinemia and Brugada pattern allowed the successful and uneventful management of general anesthesia in the study patient.
Fabio Dell’Olio +8 more
wiley +1 more source
Deciphering cilia and ciliopathies using proteomic approaches
The FEBS Journal, Volume 290, Issue 10, Page 2590-2603, May 2023., 2023 Cilia are microtubule‐based organelles that protrude from the cell surface and play crucial roles in fundamental biological processes. Here, we focus primarily on proteomic studies involving the identification of proteins in motile cilia and primary cilia, proteomes in ciliopathies, and interactomes of ciliopathy proteins. The integration of these data
Xiying Chen +4 more
wiley +1 more source