Results 41 to 50 of about 1,590 (187)

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

open access: yesPlant Biotechnology Journal, Volume 24, Issue 5, Page 2826-2842, May 2026.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu   +8 more
wiley   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang   +4 more
wiley   +1 more source

Ca2+-stimulated mitochondrial reactive oxygen species generation and permeability transition are inhibited by dibucaine or Mg2+

open access: yes, 2015
Mitochondrial swelling and membrane protein thiol oxidation associated with mitochondrial permeability transition induced by Ca2+ and t-butyl hydroperoxide or inorganic phosphate, but not 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid or phenylarsine
Kowaltowski, AJ   +7 more
core   +1 more source

Dibucaine

open access: yesReactions Weekly, 2006
europepmc   +2 more sources

Transient capacitance changes recorded from vestibular type I hair cells are produced by GK,L gating and do not involve neurotransmitter exocytosis

open access: yesThe Journal of Physiology, Volume 603, Issue 19, Page 5547-5564, October 1, 2025.
Abstract figure legend Schematic diagrams of mammalian wild type (WT) (A) and Caspr‐KO (B) type‐I vestibular hair cells showing localization of the Caspr protein (orange), the Ca2+ conductance (green) and the low‐voltage‐activated K+ conductance (blue).
Paolo Spaiardi   +4 more
wiley   +1 more source

Ca2+ uptake, fatty acid, and LDH release during proximal tubule hypoxia: effects of mepacrine and dibucaine

open access: yes, 1994
In freshly isolated hypoxic rat proximal tubules, Ca2+ uptake rate increases promptly, within 1 min, and remains significantly elevated throughout a 20-min period of hypoxia. Lactate dehydrogenase (LDH) release, a sign of membrane injury, increases only
P. Gengaro   +6 more
core   +1 more source

Natural products against tau hyperphosphorylation‐induced aggregates: Potential therapies for Alzheimer's disease

open access: yesArchiv der Pharmazie, Volume 358, Issue 1, January 2025.
This review explores the potential of natural products in modulating tau hyperphosphorylation, a pivotal molecular mechanism in Alzheimer's disease onset, by inhibiting kinases, enhancing phosphatase activity, blocking fibril formation, and promoting its disaggregation.
Gustavo Basurto‐Islas   +4 more
wiley   +1 more source

Emerging Therapeutics in the Fight Against EV‐D68: A Review of Current Strategies

open access: yesInfluenza and Other Respiratory Viruses, Volume 18, Issue 12, December 2024.
ABSTRACT Enterovirus‐D68 (EV‐D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV‐D68 was underestimated due to limited data and serotyping methods. In 2014, the United States experienced outbreaks of acute flaccid myelitis (AFM) in children EV‐D68 positive.
Nida Kalam   +1 more
wiley   +1 more source

In Situ Infrared Attenuated Total Reflection (IR ATR) Spectroscopy: A Complementary Analytical Tool for Drug Design and Drug Delivery

open access: yesCHIMIA, 1992
A comprehensive summary of basic relations for quantitative IR ATR spectroscopy of isotropie and oriented samples is given. Experimental requirements for detection of sub-monolayer quantities in aqueous environment are discussed.
Urs Peter Fringeli
doaj   +2 more sources

Effect of bilirubin on toxicity induced by trifluoperazine, dibucaine and praziquantel to erythrocytes

open access: yes, 2001
Unconjugated bilirubin (UCB), like trifluoperazine (TFP), dibucaine (DBC) and praziquantel (PZQ), induces erythrocyte morphological changes, lysis and lipid exfoliation.
Sônia V.P. Malheiros   +7 more
core   +2 more sources

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