Results 41 to 50 of about 77,494 (336)

Salmonella produce microRNA-like RNA fragment Sal-1 in the infected cells to facilitate intracellular survival. [PDF]

, 2017
Salmonella have developed a sophisticated machinery to evade immune clearance and promote survival in the infected cells. Previous studies were mostly focused on either bacteria itself or host cells, the interaction mechanism of host-pathogen awaits ...
Chen, Xi, Gu, Hongwei, Li, Donghai, Liang, Hongwei, LIU, Fenyong, Pan, Yi, Wang, Xiao-Ming, Zen, Ke, Zhang, Chen-Yu, Zhang, Tianfu, Zhao, Chihao, Zhao, Quan   +11 more
core   +2 more sources

CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma

Journal of Experimental & Clinical Cancer Research, 2019
Background CyclinD1 is crucial for cell cycling and can regulate the expression of Dicer, a crucial regulator of microRNA maturation. However, little is known on how CyclinD1 regulates Dicer and miRNA expression, and the progression of intrahepatic ...
Yongqiang Qi, Da Wang, Wenhua Huang, Bing Wang, Di Huang, Fei Xiong, Xiaoping Chen, Yongjun Chen   +7 more
doaj   +1 more source

MicroRNA-like RNAs from the same miRNA precursors play a role in cassava chilling responses [PDF]

, 2017
MicroRNAs (miRNAs) are known to play important roles in various cellular processes and stress responses. MiRNAs can be identified by analyzing reads from high-throughput deep sequencing.
Chen, Xin, Peng, Ming, Xia, Jing, Zeng, Changying, Zhang, Weixiong, Zhou, Yufei   +5 more
core   +3 more sources

Tendon-Specific Dicer Deficient Mice Exhibit Hypoplastic Tendon Through the Downregulation of Tendon-Related Genes and MicroRNAs

Frontiers in Cell and Developmental Biology, 2022
Tendon is a fibrous connective tissue, that is, transmitting the forces that permit body movement. However, tendon/ligament biology is still not fully understood and especially, the role of miRNAs in tendon/ligament is sparse and uncharacterized in in ...
Takenori Omoto, Dilimulati Yimiti, Yohei Sanada, Yohei Sanada, Minoru Toriyama, Chenyang Ding, Yuta Hayashi, Yuta Hayashi, Yasunari Ikuta, Tomoyuki Nakasa, Tomoyuki Nakasa, Masakazu Ishikawa, Masakazu Ishikawa, Masayuki Sano, Minjung Lee, Takayuki Akimoto, Chisa Shukunami, Shigeru Miyaki, Shigeru Miyaki, Nobuo Adachi   +19 more
doaj   +1 more source

Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]

, 2007
The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li, Jiehua Zhou, John Rossi, John Zaia, Shirley Li   +4 more
core   +2 more sources

Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients

BMC Cancer, 2011
Background Dicer is aberrantly expressed in several types of cancers. Applying real-time PCR, we detected the expression of Dicer mRNA in normal mucosa (n = 162), primary colorectal cancer (CRC) (n = 162) and liver metastasis (n = 37), and analysed the ...
Sun Xiao-Feng, Hinselwood David, Wallin Åsa, Gnosa Sebastian, Wang Chao-Jie, Stratmann Johannes, Zhang Hong   +6 more
doaj   +1 more source

Ancestral protein reconstruction reveals evolutionary events governing variation in Dicer helicase function

eLife, 2023
Antiviral defense in ecdysozoan invertebrates requires Dicer with a helicase domain capable of ATP hydrolysis. But despite well-conserved ATPase motifs, human Dicer is incapable of ATP hydrolysis, consistent with a muted role in antiviral defense.
Adedeji M Aderounmu, P Joseph Aruscavage, Bryan Kolaczkowski, Brenda L Bass   +3 more
doaj   +1 more source

Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]

, 2013
RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif, Frank, Wolfgang, Khraiwesh, Basel   +2 more
core   +3 more sources

Nucleotide bias of DCL and AGO in plant anti-virus gene silencing [PDF]

, 2010
Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing ...
Dalmay, Tamas, Ho, Thien, Huang, Linfeng, Li, Zhigang, Ohshima, Kazusato, Pallett, Denise W., Walsh, John A., Wang, Hui, Wang, Liang   +8 more
core   +1 more source

MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer [PDF]

Open Biology, 2013
The ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA ...
Timothy M. Johanson, Andrew M. Lew, Mark M. W. Chong   +2 more
doaj   +1 more source