Results 1 to 10 of about 102,919 (290)

Enhanced Anti-Inflammatory Effects of Nanoencapsulated Diclofenac [PDF]

European Journal of Inflammation, 2013
This study was conducted to compare the anti-inflammatory efficacy of nanoencapsulated and free-form diclofenac in rat. Diclofenac-loaded liposomes were prepared using the proliposome method.
J.Z. Goh, S.N. Tang, A. Zuraini, Z.A. Zakaria, A.A. Kadir, H.S. Chiong, M.S.O. Fauzee, M.N. Hakim   +7 more
doaj   +2 more sources

Employing diclofenac sodium as a novel therapeutic frontier for Staphylococcus epidermidis infections [PDF]

Scientific Reports
The spread of biofilm-forming multidrug-resistant pathogenic bacteria is an alarming public health issue requiring significant research. Drug repurposing is a novel approach to combating bacterial infections that is currently being studied.
Amal M. Abo-Kamar, Ahmed A. Abdelaziz, Alaa E. Ashour, Moataz A. Shaldam, Engy Elekhnawy   +4 more
doaj   +2 more sources

Combinatorial effect of diclofenac with piperine and D-limonene on inducing apoptosis and cell cycle arrest of breast cancer cells

Asian Pacific Journal of Tropical Biomedicine, 2023
Objective: To investigate the potential synergistic activity of diclofenac with piperine and D-limonene in inducing apoptosis and cell cycle arrest in breast cancer MCF-7 cells.
Srivarshini Sankar, Gothandam Kodiveri Muthukaliannan   +1 more
doaj   +1 more source

Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse [PDF]

, 2011
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
BB Dawood, BF McAdam, BJ Whittle, C Baigent, C Bombardier, C Moore, C Patrono, C Patrono, C Patrono, C Tymvios, CM Potter, D Pratico, EM Antman, F Catella-Lawson, F Giuliano, F Giuliano, G Davi, Harald H. H. W. Schmidt, JA Mitchell, Jane A. Mitchell, JJ Talley, LK Jennings, Michael Emerson, MJ Cho, N Zidar, NA Flavahan, Nicholas S. Kirkby, Paul C. Armstrong, PC Armstrong, PM Kearney, RF Storey, RJ Gryglewski, S Cronberg, S Krishnamurthi, S Moncada, SP Jackson, T Grosser, TD Warner, TD Warner, TD Warner, Timothy D. Warner, TT Niemi, WB White, Zetty N. Zain   +43 more
core   +10 more sources

Coenzyme Q10 coadministration with diclofenac augmented impaired renal function in broiler chickens (Gallus gallus domesticus) [PDF]

Veterinary World, 2020
Aim: This study aimed to investigate the effects of coenzyme Q10 (COQ10) and diclofenac coadministration on the hepatorenal function in broiler chickens (Gallus gallus domesticus).
Yasser Albadrany, Ahmed Naser
doaj   +1 more source

Electrophysiologic and anti‐inflammatorial effects of cyclooxygenase inhibition in epileptiform activity

Physiological Reports, 2023
The aim of our study is to investigate the electrophysiological and anti‐inflammatory effects of diclofenac potassium on epileptiform activity, which is the liquid form of diclofenac, and frequently used clinically for inflammatory process by inhibiting ...
Canan Akunal Türel, Hümeyra Çelik, Ayhan Çetinkaya, İdris Türel   +3 more
doaj   +1 more source

S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodeling. [PDF]

PLoS ONE, 2011
Hydrogen sulfide (H(2)S), as a novel gaseous mediator, plays important roles in mammalian cardiovascular tissues. In the present study, we investigated the cardioprotective effect of S-diclofenac (2-[(2,6-dichlorophenyl)amino] benzeneacetic acid 4-(3H-1 ...
Huili Zhang, Alian Zhang, Changfa Guo, Chunzhi Shi, Yang Zhang, Qing Liu, Anna Sparatore, Changqian Wang   +7 more
doaj   +1 more source

Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands [PDF]

, 2020
Purpose: In June 2013 a European Medicines Agency referral procedure concluded that diclofenac was associated with an elevated risk of acute cardiovascular events and contraindications, warnings, and changes to the product information were implemented ...
Bennie, Marion, Doney, Alexander S. F., Ernst, Martin Thomsen, Flynn, Robert W. V., Hallas, Jesper, Herings, Ron M. C., MacDonald, Thomas M., Mackenzie, Isla S., Mitchell, Lyn, Morales, Daniel R., Morant, Steve V., Morris, Carole, Nicholson, Lizzie, Overbeek, Jetty A., Pottegard, Anton, Robertson, Chris, Smits, Elisabeth, Wei, Li   +17 more
core   +4 more sources

Cyclic Dipeptide Shuttles as a Novel Skin Penetration Enhancement Approach: Preliminary Evaluation with Diclofenac. [PDF]

PLoS ONE, 2016
This study demonstrates the effectiveness of a peptide shuttle in delivering diclofenac into and through human epidermis. Diclofenac was conjugated to a novel phenylalanyl-N-methyl-naphthalenylalanine-derived diketopiperazine (DKP) shuttle and to TAT (a ...
Yousuf Mohammed, Meritxell Teixidó, Sarika Namjoshi, Ernest Giralt, Heather Benson   +4 more
doaj   +1 more source

Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 Hour-Short-Bowel Rats. [PDF]

PLoS ONE, 2016
Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing following major surgery and counteract diclofenac toxicity. To resolve the increasing early risks following major massive small bowel resectioning surgery, diclofenac
Nermin Lojo, Zarko Rasic, Anita Zenko Sever, Danijela Kolenc, Darko Vukusic, Domagoj Drmic, Ivan Zoricic, Marko Sever, Sven Seiwerth, Predrag Sikiric   +9 more
doaj   +1 more source