Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
Advanced Science, Volume 13, Issue 4, 19 January 2026.Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang +6 more
wiley +1 more source
The Impact of Differential Cost Sharing of Non-Steroidal Anti-Inflammatory Agents on the Use and Costs of Analgesic Drugs [PDF]
OBJECTIVE: To estimate the effect of differential cost sharing (DCS) schemes for non-steroidal anti-inflammatory drugs (NSAIDs) on drug subsidy program and beneficiary expenditures.
Adrian R. Levy +5 more
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Differential effects of misoprostol and ranitidine on the pharmacokinetics of diclofenac and gastrointestinal symptoms [PDF]
, 1993 H. G. Dammann +5 more
openalex +1 more source
Activation of Molecular Oxygen by Electron‐Rich Materials for Sustainable Soil Remediation
Advanced Science, Volume 13, Issue 4, 19 January 2026.Abundant molecular oxygen (O2) in nature can be utilized and activated by electron‐rich materials to generate reactive oxygen species for in situ engineering remediation of contaminated soil. The material types, activation mechanisms, and influencing factors are discussed in the research.
Hengxin Liu +4 more
wiley +1 more source
Comparative study of amtolmetin guacil and diclofenac sodium in patients with knee osteoarthritis [PDF]
, 2017 Vladyslav Povoroznyuk +4 more
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Neuroinflammation demonstrated by 11C‐ER176 PET with amyloid and tau pathology
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION Understanding neuroinflammation across the Alzheimer's disease (AD) spectrum is essential to elucidate disease mechanisms and individualize therapy. METHODS Human microglial translocator protein (TSPO) expression under inflammatory stimuli was assessed by immunoblot experiments.
Mahathi Kandimalla +17 more
wiley +1 more source
Involvement Of Mitochondria In Diclofenac – And Ibuprofen- Induced Hepatotoxicity [PDF]
, 2008 Diclofenac and ibuprofen are commonly used non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of rheumatic diseases. However, these drugs are known to cause hepatotoxicity in patients.
Moorthy, Mohanambal
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Metabolism‐Regulating Nanomedicines for Cancer Therapy
Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley +1 more source