Results 51 to 60 of about 102,919 (290)

Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate adenocarcinoma xenograft model

BMC Urology, 2013
Background COX-2 inhibitors have an antitumor potential and have been verified by many researchers. Treatment of cancer cells with external stressors such as irradiation can stimulate the over-expression of COX-2 and possibly confer radiation resistance.
Inoue Takeshi, Anai Satoshi, Onishi Sayuri, Miyake Makito, Tanaka Nobumichi, Hirayama Akihide, Fujimoto Kiyohide, Hirao Yoshihiko   +7 more
doaj   +1 more source

Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase activity. [PDF]

PLoS ONE, 2010
BACKGROUND: Diclofenac is one of the oldest anti-inflammatory drugs in use. In addition to its inhibition of cyclooxygenases (COX), diclofenac potently inhibits phospholipase A(2) (PLA(2)), thus yielding a broad anti-inflammatory effect.
Nina Mayorek, Nili Naftali-Shani, Myriam Grunewald   +2 more
doaj   +1 more source

Fe(II)/Chlorine‐Driven Advanced Oxidation of Textile Dyes in a Tubular Microreactor: Continuous‐Flow Performance and Matrix Effects

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The Fe(II)/chlorine system has emerged as a promising advanced oxidation technology for water treatment, yet its application in continuous‐flow systems remains unexplored. This study presents the first comprehensive investigation of the Fe(II)/chlorine process in a tubular microreactor, a setup that significantly enhances mass transfer and ...
Abderrahmane Talbi, Slimane Merouani, Aissa Dehane   +2 more
wiley   +1 more source

Nephroprotective activity of virgin coconut oil on diclofenac-induced oxidative nephrotoxicity is associated with antioxidant and anti-inflammatory effects in rats [PDF]

Avicenna Journal of Phytomedicine, 2020
Objective: Diclofenac is a non-steroidal anti-inflammatory drug linked with considerable organ toxicity caused via increased generation of reactive oxygen species.
Ademola Famurewa, Gabriel Akunna, Joseph Nwafor, Onyebuchi Chukwu, Chima Ekeleme-Egedigwe, Janet Oluniran   +5 more
doaj   +1 more source

Key physicochemical characteristics governing organic micropollutant adsorption and transport in ion-exchange membranes during reverse electrodialysis [PDF]

, 2019
The co-generation of electricity and electrodialysis of seawater in a hybrid system is a promising approach to overcome water scarcity. Reverse electrodialysis harvests energy from the salinity gradient, where seawater is used as a high salinity stream ...
Cornelissen, Emile, Gutierrez, L, Post, JW, Roman, M, Van Dijk, LH, Vanoppen, Marjolein, Verliefde, Arne, Wols, BA   +7 more
core   +1 more source

The impact of non‐steroidal anti‐inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: 10‐year results from an inception cohort

Arthritis &Rheumatology, Accepted Article.
Objectives This study aims to investigate the impact of non‐steroidal anti‐inflammatory drug (NSAID) intake on radiographic spinal progression in axial spondyloarthritis (axSpA), considering different NSAID types (COX‐2 inhibitors [COX2i] and non‐selective NSAIDs [ns‐NSAIDs]) and disease subgroups (radiographic (r‐axSpA) and non‐radiographic (nr‐axSpA).
Murat Torgutalp, Valeria Rios Rodriguez, Fabian Proft, Mikhail Protopopov, Judith Rademacher, Hildrun Haibel, Joachim Sieper, Martin Rudwaleit, Denis Poddubnyy   +8 more
wiley   +1 more source

Efficacy and tolerability of Potentilla tincture in complex therapy of patients with knee osteoarthritis

Научно-практическая ревматология, 2009
Objective. To assess efficacy and safety of two-month therapy with Potentilla tincturecombined with diclofenac in pts with osteoarthritis (OA) in comparison with diclofenac monotherapy (control group). Material and methods.
L N Denisov, N V Shostak, E N Shmidt, Z A Prozorovskaya, N M Babadaeva   +4 more
doaj   +1 more source

New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells. [PDF]

PLoS ONE, 2013
Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects. Up to now these effects were mainly attributed to its classical role as COX-inhibitor. Here we show novel COX-independent effects of diclofenac.
Eva Gottfried, Sven A Lang, Kathrin Renner, Anja Bosserhoff, Wolfram Gronwald, Michael Rehli, Sabine Einhell, Isabel Gedig, Katrin Singer, Anton Seilbeck, Andreas Mackensen, Oliver Grauer, Peter Hau, Katja Dettmer, Reinhard Andreesen, Peter J Oefner, Marina Kreutz   +16 more
doaj   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

The effect of diclofenac on proliferation and production of growth factors by endothelial cells (HMEC-1) under hypoxia and inflammatory conditions

Acta Pharmaceutica, 2014
Diclofenac belongs to non-steroidal anti-inflammatory drugs (NSAIDs) and non-selective COX inhibitors. The aim of this study was to examine the effect of diclofenac on endothelial cell proliferation under the influence of hypoxia or inflammatory ...
Wiktorowska-Owczarek Anna
doaj   +1 more source