Results 191 to 200 of about 20,321 (243)

Thermal behaviour of diclofenac, diclofenac sodium and sodium bicarbonate compositions

Journal of Thermal Analysis and Calorimetry, 2007
This work aims to investigate the thermal behaviour of diclofenac, diclofenac sodium, and NaHCO3 both as single components and binary mixtures. In particular, the melting point and latent heat of fusion binary diagrams of the diclofenac sodium/diclofenac mixtures at different mole fraction compositions were investigated in order to gain information ...
Irene Pasquali, R. Bettini, F. Giordano
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Electrospun Multifunctional Diclofenac Sodium Releasing Nanoscaffold

Journal of Nanoscience and Nanotechnology, 2006
Electrospinning is a method utilized to produce nano-scale fibers for tissue engineering applications. A variety of cells are attracted by nano scale surfaces and structures probably due to the similarity of their natural environment scale. In this study, diclofenac sodium (DS) releasing nanofibers were manufactured via electrospinning process.
L, Nikkola, J, Seppälä, A, Harlin, A, Ndreu, N, Ashammakhi   +4 more
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Diclofenac Sodium Injection (Dyloject®)

Drugs, 2008
*A new formulation of the nonselective NSAID diclofenac sodium suitable for intravenous bolus injection has been developed using hydroxypropyl beta-cyclodextrin as a solubility enhancer (HPbetaCD diclofenac). * HPbetaCD diclofenac intravenous bolus injection was shown to be bioequivalent to the existing parenteral formulation of diclofenac containing ...
Paul L, McCormack, Lesley J, Scott
openaire   +2 more sources

Diclofenac Sodium and Bruising

Annals of Internal Medicine, 1990
Excerpt To the Editor:No reports to date have described prolonged bleeding time and spontaneous bruising with the use of diclofenac sodium.
Uri Khazan, Mary Toth, Anand Mutgi
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Analysis of diclofenac sodium and derivatives

Journal of Pharmaceutical and Biomedical Analysis, 1999
There are two reasons explaining why several researchers have carried out the in vitro release studies of diclofenac sodium (DFNa) using pH media of above 6.5. Firstly the pH dependence of solubility, and secondly the intramolecular cyclization suffered under acidic conditions which causes the salt to become inactivated. Nevertheless, many commercially
M E, Palomo, M P, Ballesteros, P, Frutos
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Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man

European Journal of Clinical Pharmacology, 1990
A phamacokinetic study in man has been made of a new dosage form of diclofenac hydroxyethylpyrrolidine (DIEP); soluble salt packed in sachets was compared with diclofenac sodium as enteric coated tablets. Oral DIEP 2 X 50 mg showed a significant difference in absorption kinetics (ka, lag time and tmax) as compared to oral diclofenac sodium 2 X 50 mg. A
C A, Maggi, P, Lualdi, G, Mautone
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Systemic Bioavailability of Topical Diclofenac Sodium Gel 1% Versus Oral Diclofenac Sodium in Healthy Volunteers

The Journal of Clinical Pharmacology, 2010
Systemic bioavailability and pharmacodynamics of topical diclofenac sodium gel 1% were compared with those of oral diclofenac sodium 50‐mg tablets. In a randomized, 3‐way crossover study, healthy volunteers (n = 40) received three 7‐day diclofenac regimens: (A) 16 g gel applied as 4 g to 1 knee 4 times daily (4 g on surface area 400 cm2), (B) 48 g gel ...
Jean-Luc, Kienzler, Morris, Gold, Fabrice, Nollevaux   +2 more
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Diclofenac sodium.

Clinical pharmacy, 1989
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of diclofenac sodium are reviewed. Diclofenac, the first nonsteroidal anti-inflammatory agent (NSAID) to be approved that is a phenylacetic acid derivative, competes with arachidonic acid for binding to cyclo-oxygenase, resulting in decreased formation of prostaglandins.
openaire   +1 more source

Diclofenac Sodium Loaded Multicomponent Implant

AIP Conference Proceedings, 2008
Earlier we have reported on developing DS releasing bioabsorbable rods for inhibition of osteolysis [l]. Due to their unsatisfactory drug release profiles we assessed the use of sintering technique of enhancement of drug release in the current study. Melt extruded PLGA 80/20 rods were compounded 8 wt‐% DS.
Lila Nikkola, Petrus Viitanen, Nureddin Ashammakhi, Glaucio H. Paulino, Marek-Jerzy Pindera, Robert H. Dodds, Fernando A. Rochinha, Eshan Dave, Linfeng Chen   +8 more
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Taste masking of diclofenac sodium using microencapsulation

Journal of Microencapsulation, 2002
This study addresses how to mask the undesirable taste of diclofenac sodium (DS) without interfering with an adequate rate of drug release. DS microcapsules were successfully prepared using a system of ethylcellulose (EC)-toluene-petroleum ether. The system was optimized by the construction of the phase diagram and determination of the amount of EC ...
M F, Al-Omran, S A, Al-Suwayeh, A M, El-Helw, S I, Saleh   +3 more
openaire   +2 more sources