Results 181 to 190 of about 81,226 (245)

Divergent Synthesis of 1-Aminonaphthalene Derivatives via the Diels-Alder Reaction of 3-Aminoarynes. [PDF]

J Org Chem
Okada T, Kawada M, Yoshida S.
europepmc   +1 more source

Targeted Protein Degradation: From Molecular Mechanisms to Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Graphical overview of targeted protein degradation: mechanisms, molecular determinants, delivery strategies, and therapeutic development. This graphical abstract summarizes the major degradation pathways involved in targeted protein degradation, including the ubiquitin–proteasome system, endocytosis–lysosome pathway, and autophagy‐dependent degradation.
Huaijuan Guo, Haishuang Duan, Yang Liu, Kelan Fang, Lujia Xiao, Ling Bai, Xiao Qu, Xuebing Yan, Kun Zhang   +8 more
wiley   +1 more source

A Machine Learning-Guided Study of Structure-Reactivity Relationships in Diels-Alder Cycloadditions. [PDF]

J Org Chem
Mahdian A, Farshadfar K, Laasonen K.
europepmc   +1 more source

An Investigations‐Based Undergraduate Computational Chemistry Course

Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.
Chemistry 164 is a hands‐on undergraduate computational chemistry course at Pomona College using publicly available materials (https://tinyurl.com/PomonaChem164) and structured around literature‐based investigations of organic structure and reactivity, isotope effects, NMR parameters, and organometallic systems.
Daniel J. O'Leary
wiley   +1 more source

Ynimines as versatile precursors to 2-imido- and 2-amido-1,3-dienes for stereodivergent diels-alder reactions. [PDF]

Nat Commun
Wang R, Zhu XQ, Djaïd M, Lavernhe R, Wang Q, Zhu J.   +5 more
europepmc   +1 more source

Systematic Optimization of an SLE‐DAPTAD LC–MS/MS Workflow for Simultaneous Quantification of Low‐Abundance Vitamin D3 Metabolites in Plasma

Rapid Communications in Mass Spectrometry, Volume 40, Issue 20, 30 October 2026.
ABSTRACT Rationale Liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis of vitamin D3 metabolites is analytically challenging because these compounds are structurally similar, strongly matrix‐associated, and have poor ionization efficiency.
Marzieh Amirmostofian, Michael D. Wiese, Paul H. Anderson, Peter Hoffmann   +3 more
wiley   +1 more source

Thermally Reversible and Recyclable Polyethylene Networks via Furan-Maleimide Diels-Alder Dynamic Covalent Chemistry. [PDF]

Molecules
Hao Z, Zhang W, Liu Y, Xu J, Liu H, Tang S, Shen J.   +6 more
europepmc   +1 more source

Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
This review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Neil Taylor, João de Sousa‐Lourenço, Ivana Nikić‐Spiegel   +2 more
wiley   +1 more source

Supramolecular Mechanophore Additives Enable Mechanochromic Hydrogels

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
A supramolecular loop‐forming mechanophore featuring a quencher and an emitter is incorporated as a water‐soluble macromolecular additive into hydrogels. In the stress‐free state, intramolecular charge‐transfer interactions fold the loop and quench fluorescence.
Iulia Scarlat, Jess M. Clough, Christoph Weder   +2 more
wiley   +2 more sources

Sustainable Routes Toward Amino Acid‐Based Surfactants: Borrowing Hydrogen Catalysis and Beyond

ChemSusChem, Volume 19, Issue 20, 28 October 2026.
This perspective examines how amino acid‐based surfactants become more sustainable only when molecular architecture is matched to an appropriate synthetic disconnection. Borrowing Hydrogen catalysis provides a central route to N‐alkylated derivatives, while enzymatic, biosynthetic, and renewable‐platform strategies complement it.
Maximilian Fellert, Ben L. Feringa
wiley   +1 more source