Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology
European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau +3 more
wiley +1 more source
Molybdooxaziridine Catalysis: Synthesis of α‐Hydroxysulfones From Styrenes Through an ATRA Process
European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.This work has discovered that molybdooxaziridine catalysts promote the hydroxysulfonation of substituted α‐methyl‐styrenes using N‐Ts‐hydroxylamine as the nitrogen source. An atom‐transfer‐radical‐addition mechanism involving the stepwise addition of Ts and hydroxy radicals takes place.
Alyssa N. Singer, Gustavo Moura‐Letts
wiley +1 more source
Phytochemical Profiling of Mulberry Diels-Alder Adducts as Selective Butyrylcholinesterase Inhibitors: In Vitro Activity, Molecular Docking, and Molecular Dynamics Simulation. [PDF]
MoleculesCui X +8 more
europepmc +1 more source
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.Erneuerbare Guajacole werden durch Phenyliodid(III)diacetat rasch zu maskierten ortho‐Chinonen oxidiert und bilden eine neue Monomerklasse, die mit Multithiolen selektive Michael‐Typ‐Polyadditionen zu Polymeren mit Thiol‐Guajacol‐Verknüpfungen eingeht.
Dominik P. Hoch +7 more
wiley +1 more source
Utilizing the Pentadehydro-Diels-Alder Reaction for Polycyclic Aromatic Compound Synthesis: Diels-Alder-Based Linker Transformation. [PDF]
MoleculesXia Y, Liang Q, Zhu C, Sun B.
europepmc +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 43, 19 October 2026.Renewable guaiacols are rapidly oxidized by phenyliodine(III)diacetate to masked ortho‐quinones, giving a new class of monomers that undergo selective Michael‐type polyaddition with multithiols to from thiol‐guaiacol connectivity‐bearing polymers. The activation applies to discrete monomers and directly to lignin, enabling two‐component adhesives that ...
Dominik P. Hoch +7 more
wiley +1 more source
The Diels-Alder Reaction as a Mechanistic Probe for Vibrational Strong Coupling. [PDF]
Angew Chem Int Ed EnglMuller C, Piejko M, Bascil S, Moran J.
europepmc +1 more source
Toward Ideal Proximity‐Driven Reactions in Chemical Biology
ChemBioChem, Volume 27, Issue 19, 14 October 2026.Building on established principles of molecular templation, this perspective explores how molecular recognition can control chemical reactivity in space and time and outlines the design principles of an ideal proximity‐driven reaction for chemical biology.
Dominik Schauenburg
wiley +1 more source
Regiochemical Control of Shape Morphing in Diels-Alder Covalent Adaptable Networks. [PDF]
ACS Macro LettZhao Y, Moon J, Sukhishvili SA.
europepmc +1 more source
A Unified Approach for the Synthesis of Conformationally Locked and sp2‐sp3 Fused Hybrids
Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.This study presents a systematic platform to build rigid sp2–sp3 hybrids via benzyne cycloadditions. Arene‑fused bicyclic oxa‐, aza‐, and carbocycles are converted into medicinally relevant amino acids and applied to Enalapril analogues synthesis. The hybrids combine aromatic interactions with 3D rigidity, tuning lipophilicity, pKa, and solubility ...
Ervis Saraci +8 more
wiley +1 more source