Results 91 to 100 of about 1,252,753 (304)

Integrative Proteomic and Bioenergetic Profiling Reveals Diet- and Strain-Specific Mitochondrial Dysfunction in Cohen Diabetic Rat Hearts

Antioxidants
Mitochondrial dysfunction contributes to diabetic cardiomyopathy, yet how genetic predisposition and diet interact to reshape cardiac metabolism in diabetic and prediabetic states remains unclear.
Lauren Pavelich, Tasnim Arroum, Lucynda Pham, Dragana Komnenov, Paul M. Stemmer, Rachel Lax, Ann Saada, Sarah Weksler-Zangen, Maik Hüttemann   +8 more
doaj   +1 more source

Effects of diet and diabetes on maternal weight gain.

, 2013
Pregnant females were weighed on the day the copulation plug was detected (E0.5), and before sacrifice. Weight gain was calculated as the difference between weight on E18.5 and E0.5. Bar diagrams depict means and standard deviations.
Claudia Kappen (8082), Jacalyn MacGowan (319714), J. Michael Salbaum (319716), Claudia Kruger (141215)   +3 more
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Cholesterol gallstones in alloxan-diabetic mice.

Journal of Lipid Research, 1990
Normal and alloxan-diabetic male mice (Crj-ICR) were fed a diet containing 0.5% cholesterol for 5 and 10 weeks, and gallbladder bile was analyzed for cholesterol, phospholipids and bile acids, feces for sterols and bile acids, and plasma and liver for ...
T Akiyoshi, K Uchida, H Takase, Y Nomura, N Takeuchi   +4 more
doaj   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

The Effects of Soybean Diet on the Diabetic Neuropathy in the Rats

, 2006
Neuropathy is a serious and disabling complication that contributes to increased morbidity and mortality in diabetic patients. There is progressive distal to proximal axonal atrophy that ultimately leads to Wallerian degeneration.
이원택, 김승민, 박경아
core  

Screening attendance, age group and diabetic retinopathy level at first screen [PDF]

, 2016
AIMS: To report on the relationships between age at diagnosis of diabetes, time from registration with the screening programme to first diabetic eye screening and severity of diabetic retinopathy.
Bachmann, M.O., Bachmann, M O, I. M. Stratton, Leese, G.P., Ferguson, B, Jones, C., the Four Nations Diabetic Retinopathy Screening Study Group, Leese, G. P., M. O. Bachmann, Scanlon, P.H., G. P. Leese, Stratton, I.M., Ferguson, B., Scanlon, P. H., Leese, G P, Land, M., B Ferguson, Stratton, I M, C. Jones, M. Land, Stratton, I. M., Land, M, P. H. Scanlon, Jones, C, Bachmann, M. O., Scanlon, Peter H   +25 more
core   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

The protective effects of Crocin on testopathy in fat-fed and streptozotocin-treated diabetic rats: An experimental study

International Journal of Reproductive BioMedicine, 2019
Background Male hypogonadism is associated with type II diabetes mellitus due to testicular dysfunction. Medicinal plants have received considerable attention for the management of diabetes and its complications.
Saeed Mirzaee, Mohammad Ehsan Bayatpoor, Shima Shahyad, Mohammad Taghi Mohammadi, Zahra Bahari   +4 more
doaj   +1 more source